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    FOXR1 forkhead box R1 [ Homo sapiens (human) ]

    Gene ID: 283150, updated on 3-Apr-2024

    Summary

    Official Symbol
    FOXR1provided by HGNC
    Official Full Name
    forkhead box R1provided by HGNC
    Primary source
    HGNC:HGNC:29980
    See related
    Ensembl:ENSG00000176302 MIM:615755; AllianceGenome:HGNC:29980
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FOXN5; DLNB13
    Summary
    This gene encodes a member of the forkhead box (FOX) family of transcription factors. FOX family members are monomeric, helix-turn-helix proteins with a core DNA-binding domain of approximately 110 aa. Many FOX transcription factors play roles in determining cell fates during early development. This forkhead box protein lacks the C-terminal basic region found in many other FOX family members. It is located within the 11q23.3 region which is commonly deleted in neuroblastomas. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward testis (RPKM 1.2) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See FOXR1 in Genome Data Viewer
    Location:
    11q23.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (118971761..118981287)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (118992171..119001685)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (118842471..118851997)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 688, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:118810343-118811124 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:118811125-118811904 Neighboring gene uroplakin 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:118842491-118842991 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:118850851-118851369 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:118851370-118851887 Neighboring gene uncharacterized LOC124902768 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5614 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:118868291-118868816 Neighboring gene CENATAC divergent transcript

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC149486

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    part_of chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    forkhead box protein R1
    Names
    forkhead box protein N5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181721.3NP_859072.1  forkhead box protein R1

      See identical proteins and their annotated locations for NP_859072.1

      Status: REVIEWED

      Source sequence(s)
      AB094092, AP003392, BC038969
      Consensus CDS
      CCDS31688.1
      UniProtKB/Swiss-Prot
      B0YJ15, Q08AS8, Q6PIV2, Q86UT9, Q8IXX2
      Related
      ENSP00000314806.3, ENST00000317011.8
      Conserved Domains (1) summary
      pfam00250
      Location:173261
      Forkhead; Forkhead domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      118971761..118981287
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017017575.2XP_016873064.1  forkhead box protein R1 isoform X1

    2. XM_017017576.2XP_016873065.1  forkhead box protein R1 isoform X2

    3. XM_047426801.1XP_047282757.1  forkhead box protein R1 isoform X3

      UniProtKB/TrEMBL
      B0YJ16
      Related
      ENSP00000432358.1, ENST00000533282.1

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_009646203.1 Reference GRCh38.p14 PATCHES

      Range
      382..2887
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      118992171..119001685
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054368476.1XP_054224451.1  forkhead box protein R1 isoform X1

    2. XM_054368477.1XP_054224452.1  forkhead box protein R1 isoform X2

    3. XM_054368478.1XP_054224453.1  forkhead box protein R1 isoform X3

      UniProtKB/TrEMBL
      B0YJ16