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    GPR3 G protein-coupled receptor 3 [ Homo sapiens (human) ]

    Gene ID: 2827, updated on 17-Jun-2024

    Summary

    Official Symbol
    GPR3provided by HGNC
    Official Full Name
    G protein-coupled receptor 3provided by HGNC
    Primary source
    HGNC:HGNC:4484
    See related
    Ensembl:ENSG00000181773 MIM:600241; AllianceGenome:HGNC:4484
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ACCA
    Summary
    This gene is a member of the G protein-coupled receptor family and is found in the cell membrane. G protein-coupled receptors, characterized by a seven transmembrane domain motif, are involved in translating outside signals into G protein mediated intracellular effects. The encoded protein activates adenylate cyclase and modulates amyloid-beta production in a mouse model, suggesting that it may play a role in Alzheimer's disease. [provided by RefSeq, Oct 2012]
    Expression
    Broad expression in brain (RPKM 2.0), thyroid (RPKM 0.6) and 17 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See GPR3 in Genome Data Viewer
    Location:
    1p36.11
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (27392622..27395814)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (27233946..27237138)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (27719126..27722318)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ficolin 3 Neighboring gene CD164 molecule like 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:27717742-27718278 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27718279-27718815 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 515 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27719353-27719888 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27720717-27721514 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:27725651-27726603 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 547 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 548 Neighboring gene Sharpr-MPRA regulatory region 8314 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 549 Neighboring gene WASP family member 2 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27756559-27757532 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 550 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 516 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 551 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 552 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 517 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 518 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27816920-27817464 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27817465-27818009 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 554 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27830147-27830734 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27830735-27831320 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27831321-27831907 Neighboring gene uncharacterized LOC105376892 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27849319-27849901 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:27851813-27852451 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 519 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 520 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:27855359-27856073

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cAMP-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in regulation of cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of meiotic nuclear division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    G-protein coupled receptor 3
    Names
    ACCA orphan receptor
    adenylate cyclase constitutive activator

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005281.4NP_005272.1  G-protein coupled receptor 3

      See identical proteins and their annotated locations for NP_005272.1

      Status: REVIEWED

      Source sequence(s)
      FO393419
      Consensus CDS
      CCDS303.1
      UniProtKB/Swiss-Prot
      A8K570, P46089
      UniProtKB/TrEMBL
      F1DAM5
      Related
      ENSP00000363136.3, ENST00000374024.4
      Conserved Domains (2) summary
      cd14964
      Location:4367
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:41308
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      27392622..27395814
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      27233946..27237138
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)