U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    IFNL2 interferon lambda 2 [ Homo sapiens (human) ]

    Gene ID: 282616, updated on 11-Apr-2024

    Summary

    Official Symbol
    IFNL2provided by HGNC
    Official Full Name
    interferon lambda 2provided by HGNC
    Primary source
    HGNC:HGNC:18364
    See related
    Ensembl:ENSG00000183709 MIM:607401; AllianceGenome:HGNC:18364
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IL28A; IFNL2a; IFNL3a; IL-28A
    Summary
    This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28B (IL28B), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]
    Expression
    Low expression observed in reference dataset See more
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See IFNL2 in Genome Data Viewer
    Location:
    19q13.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (39268396..39270188)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (42072661..42074453)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (39759036..39760828)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr19.4063 Neighboring gene methionine sulfoxide reductase B1 pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:39755018-39755596 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:39755597-39756176 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:39756177-39756754 Neighboring gene interferon lambda 4 pseudogene 1 Neighboring gene interferon lambda 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:39798467-39798968 Neighboring gene leucine rich repeat and fibronectin type III domain containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10596

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway via JAK-STAT IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to virus NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in defense response to virus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in defense response to virus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mucosal immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in type III interferon-mediated signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    interferon lambda-2
    Names
    IFN-lambda-2
    cytokine Zcyto20
    interleukin 28A (interferon, lambda 2)
    interleukin-28A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172138.2NP_742150.1  interferon lambda-2 precursor

      See identical proteins and their annotated locations for NP_742150.1

      Status: VALIDATED

      Source sequence(s)
      AA774195, AC011445, AY129148
      Consensus CDS
      CCDS42567.1
      UniProtKB/Swiss-Prot
      Q45KQ8, Q6VN55, Q8IWL7, Q8IZJ0
      UniProtKB/TrEMBL
      A0A7R8C362
      Related
      ENSP00000333639.5, ENST00000331982.6
      Conserved Domains (1) summary
      pfam15177
      Location:38191
      IL28A; Interleukin-28A

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      39268396..39270188
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791808.1 Reference GRCh38.p14 PATCHES

      Range
      48778..50570
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      42072661..42074453
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)