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    GPC1 glypican 1 [ Homo sapiens (human) ]

    Gene ID: 2817, updated on 8-Jul-2021

    Summary

    Official Symbol
    GPC1provided by HGNC
    Official Full Name
    glypican 1provided by HGNC
    Primary source
    HGNC:HGNC:4449
    See related
    Ensembl:ENSG00000063660 MIM:600395
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    glypican
    Summary
    Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in skin (RPKM 51.0), testis (RPKM 21.8) and 19 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See GPC1 in Genome Data Viewer
    Location:
    2q37.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (240435663..240468076)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (241375080..241407493)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723825 Neighboring gene NFE2L2 motif-containing MPRA enhancer 30 Neighboring gene Sharpr-MPRA regulatory region 14717 Neighboring gene uncharacterized LOC100130449 Neighboring gene microRNA 149 Neighboring gene ankyrin repeat and MYND domain containing 1 Neighboring gene Sharpr-MPRA regulatory region 11390 Neighboring gene conserved acetylation island sequence C08 enhancer Neighboring gene dual specificity phosphatase 28

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype.
    GeneReviews: Not available

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    capsid gag The interaction of HIV-1 CA with human cellular glypican 1 protein (GPC1) is identified by yeast two-hybrid screen PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ38078

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables copper ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables fibroblast growth factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables fibroblast growth factor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables laminin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in Schwann cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in heparan sulfate proteoglycan catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in myelin assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of fibroblast growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of fibroblast growth factor receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of skeletal muscle cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of protein localization to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi lumen TAS
    Traceable Author Statement
    more info
     
    located_in anchored component of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in extracellular matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in extracellular region HDA PubMed 
    located_in extracellular space TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in intrinsic component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in lysosomal lumen TAS
    Traceable Author Statement
    more info
     
    colocalizes_with membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane raft ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    glypican-1
    Names
    epididymis secretory sperm binding protein
    glypican proteoglycan 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002081.3NP_002072.2  glypican-1 precursor

      See identical proteins and their annotated locations for NP_002072.2

      Status: REVIEWED

      Source sequence(s)
      AC110619, BG825129, X54232
      Consensus CDS
      CCDS2534.1
      UniProtKB/Swiss-Prot
      P35052
      Related
      ENSP00000264039.2, ENST00000264039.7
      Conserved Domains (1) summary
      pfam01153
      Location:22533
      Glypican

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

      Range
      240435663..240468076
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011510976.2XP_011509278.1  glypican-1 isoform X1

      UniProtKB/TrEMBL
      H7C410
      Related
      ENSP00000415077.2, ENST00000420138.5
      Conserved Domains (1) summary
      pfam01153
      Location:1461
      Glypican; Glypican
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