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    Cep63 centrosomal protein 63 [ Mus musculus (house mouse) ]

    Gene ID: 28135, updated on 17-Aug-2021

    Summary

    Official Symbol
    Cep63provided by MGI
    Official Full Name
    centrosomal protein 63provided by MGI
    Primary source
    MGI:MGI:2158560
    See related
    Ensembl:ENSMUSG00000032534
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ET2; CD20; CD20R; D9Mgc41; AW107703; D9Mgc48e; 4921501M07; AL450317.13gm1
    Summary
    This gene encodes a subunit of the centrosome, the main microtubule-organizing center of the cell. The encoded protein associates with another centrosomal protein, CEP152, to regulate mother-centriole-dependent centriole duplication in dividing cells. Disruption of a similar gene in human has been associated with primary microcephaly (MCPH). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
    Expression
    Biased expression in testis adult (RPKM 38.6), CNS E11.5 (RPKM 4.6) and 10 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cep63 in Genome Data Viewer
    Location:
    9 F1; 9 54.61 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (102463777..102503767, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (102586578..102626564, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (102488908..102528454, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene karyopherin alpha 7 (importin alpha 8) pseudogene Neighboring gene predicted gene 29387 Neighboring gene WD repeat domain 85 pseudogene Neighboring gene anaphase promoting complex subunit 13 Neighboring gene VISTA enhancer mm1302 Neighboring gene predicted gene, 46150

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    centrosomal protein of 63 kDa
    Names
    centrosome protein Cep63

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081122.1NP_001074591.1  centrosomal protein of 63 kDa isoform 1

      See identical proteins and their annotated locations for NP_001074591.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK076549, AV255301, KC211185
      Consensus CDS
      CCDS40743.1
      UniProtKB/TrEMBL
      F8VPJ7, U5KVR9
      Related
      ENSMUSP00000091306.4, ENSMUST00000093791.10
      Conserved Domains (1) summary
      pfam17045
      Location:76338
      CEP63; Centrosomal protein of 63 kDa
    2. NM_001301689.1NP_001288618.1  centrosomal protein of 63 kDa isoform 2

      See identical proteins and their annotated locations for NP_001288618.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks multiple alternate in-frame exons in the 3' coding region compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
      Source sequence(s)
      AK076549, AV255301, KC211185
      Consensus CDS
      CCDS90650.1
      UniProtKB/TrEMBL
      U5KVR9
      Related
      ENSMUSP00000149157.2, ENSMUST00000216281.2
      Conserved Domains (1) summary
      pfam17045
      Location:76338
      CEP63; Centrosomal protein of 63 kDa

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      102463777..102503767 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017313415.3XP_017168904.1  centrosomal protein of 63 kDa isoform X22

      Conserved Domains (2) summary
      TIGR02168
      Location:76422
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam17045
      Location:18239
      CEP63; Centrosomal protein of 63 kDa
    2. XM_006511747.5XP_006511810.1  centrosomal protein of 63 kDa isoform X15

      Conserved Domains (2) summary
      TIGR02169
      Location:145498
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam17045
      Location:18239
      CEP63; Centrosomal protein of 63 kDa
    3. XM_036155044.1XP_036010937.1  centrosomal protein of 63 kDa isoform X12

      Conserved Domains (2) summary
      COG1196
      Location:216522
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam17045
      Location:76297
      CEP63; Centrosomal protein of 63 kDa
    4. XM_011242886.2XP_011241188.1  centrosomal protein of 63 kDa isoform X11

      Conserved Domains (2) summary
      TIGR02169
      Location:224577
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam17045
      Location:97318
      CEP63; Centrosomal protein of 63 kDa
    5. XM_017313406.1XP_017168895.1  centrosomal protein of 63 kDa isoform X1

      Conserved Domains (2) summary
      pfam15921
      Location:102667
      CCDC158; Coiled-coil domain-containing protein 158
      pfam17045
      Location:97359
      CEP63; Centrosomal protein of 63 kDa
    6. XM_011242890.3XP_011241192.1  centrosomal protein of 63 kDa isoform X16

      Conserved Domains (2) summary
      COG1196
      Location:278563
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam17045
      Location:97359
      CEP63; Centrosomal protein of 63 kDa
    7. XM_030244411.2XP_030100271.1  centrosomal protein of 63 kDa isoform X20

      Conserved Domains (2) summary
      TIGR02168
      Location:139485
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam17045
      Location:81302
      CEP63; Centrosomal protein of 63 kDa
    8. XM_017313416.3XP_017168905.1  centrosomal protein of 63 kDa isoform X23

      Conserved Domains (1) summary
      pfam05483
      Location:51247
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
    9. XM_017313414.3XP_017168903.1  centrosomal protein of 63 kDa isoform X21

      UniProtKB/Swiss-Prot
      Q3UPP8
      Related
      ENSMUSP00000125621.2, ENSMUST00000162655.9
      Conserved Domains (2) summary
      COG1196
      Location:199484
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam17045
      Location:18280
      CEP63; Centrosomal protein of 63 kDa
    10. XM_006511741.3XP_006511804.1  centrosomal protein of 63 kDa isoform X10

      Conserved Domains (2) summary
      pfam15921
      Location:42639
      CCDC158; Coiled-coil domain-containing protein 158
      pfam17045
      Location:69331
      CEP63; Centrosomal protein of 63 kDa
    11. XM_017313409.2XP_017168898.1  centrosomal protein of 63 kDa isoform X8

      Conserved Domains (2) summary
      pfam15921
      Location:45650
      CCDC158; Coiled-coil domain-containing protein 158
      pfam17045
      Location:80342
      CEP63; Centrosomal protein of 63 kDa
    12. XM_017313412.2XP_017168901.1  centrosomal protein of 63 kDa isoform X18

      Conserved Domains (2) summary
      pfam15921
      Location:45576
      CCDC158; Coiled-coil domain-containing protein 158
      pfam17045
      Location:80342
      CEP63; Centrosomal protein of 63 kDa
    13. XM_017313413.3XP_017168902.1  centrosomal protein of 63 kDa isoform X19

      Conserved Domains (2) summary
      COG1196
      Location:250535
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam17045
      Location:69331
      CEP63; Centrosomal protein of 63 kDa
    14. XM_011242885.3XP_011241187.1  centrosomal protein of 63 kDa isoform X9

      Conserved Domains (2) summary
      pfam15921
      Location:53635
      CCDC158; Coiled-coil domain-containing protein 158
      pfam17045
      Location:70332
      CEP63; Centrosomal protein of 63 kDa
    15. XM_017313407.2XP_017168896.1  centrosomal protein of 63 kDa isoform X4

      Conserved Domains (2) summary
      pfam15921
      Location:91656
      CCDC158; Coiled-coil domain-containing protein 158
      pfam17045
      Location:86348
      CEP63; Centrosomal protein of 63 kDa
    16. XM_017313408.2XP_017168897.1  centrosomal protein of 63 kDa isoform X6

      Conserved Domains (2) summary
      pfam15921
      Location:46646
      CCDC158; Coiled-coil domain-containing protein 158
      pfam17045
      Location:81343
      CEP63; Centrosomal protein of 63 kDa
    17. XM_017313411.3XP_017168900.1  centrosomal protein of 63 kDa isoform X17

      Conserved Domains (2) summary
      pfam15921
      Location:46577
      CCDC158; Coiled-coil domain-containing protein 158
      pfam17045
      Location:81343
      CEP63; Centrosomal protein of 63 kDa
    18. XM_006511745.5XP_006511808.1  centrosomal protein of 63 kDa isoform X14

      See identical proteins and their annotated locations for XP_006511808.1

      UniProtKB/Swiss-Prot
      Q3UPP8
      Conserved Domains (2) summary
      pfam15921
      Location:1583
      CCDC158; Coiled-coil domain-containing protein 158
      pfam17045
      Location:18280
      CEP63; Centrosomal protein of 63 kDa
    19. XM_006511744.4XP_006511807.1  centrosomal protein of 63 kDa isoform X13

      See identical proteins and their annotated locations for XP_006511807.1

      Conserved Domains (2) summary
      TIGR02169
      Location:202555
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam17045
      Location:34296
      CEP63; Centrosomal protein of 63 kDa
    20. XM_011242882.3XP_011241184.1  centrosomal protein of 63 kDa isoform X3

      Conserved Domains (2) summary
      pfam15921
      Location:97662
      CCDC158; Coiled-coil domain-containing protein 158
      pfam17045
      Location:92354
      CEP63; Centrosomal protein of 63 kDa
    21. XM_011242883.3XP_011241185.1  centrosomal protein of 63 kDa isoform X5

      Conserved Domains (2) summary
      pfam15921
      Location:90655
      CCDC158; Coiled-coil domain-containing protein 158
      pfam17045
      Location:85347
      CEP63; Centrosomal protein of 63 kDa
    22. XM_006511739.3XP_006511802.1  centrosomal protein of 63 kDa isoform X2

      Conserved Domains (2) summary
      pfam15921
      Location:101666
      CCDC158; Coiled-coil domain-containing protein 158
      pfam17045
      Location:96358
      CEP63; Centrosomal protein of 63 kDa
    23. XM_011242884.3XP_011241186.1  centrosomal protein of 63 kDa isoform X7

      Conserved Domains (2) summary
      pfam15921
      Location:86651
      CCDC158; Coiled-coil domain-containing protein 158
      pfam17045
      Location:81343
      CEP63; Centrosomal protein of 63 kDa

    RNA

    1. XR_004935447.1 RNA Sequence

    2. XR_004935448.1 RNA Sequence

    3. XR_001778924.1 RNA Sequence

    4. XR_001778922.1 RNA Sequence

    5. XR_003947926.1 RNA Sequence

    6. XR_004935446.1 RNA Sequence

    7. XR_001778923.3 RNA Sequence

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