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    TNF tumor necrosis factor [ Bos taurus (cattle) ]

    Gene ID: 280943, updated on 2-Oct-2018

    Summary

    Official Symbol
    TNFprovided by VGNC
    Official Full Name
    tumor necrosis factorprovided by VGNC
    Primary source
    VGNC:VGNC:36153
    See related
    BGD:BT10618; Ensembl:ENSBTAG00000025471
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    TNFa; TNF-a; TNF-alpha
    Orthologs

    Genomic context

    See TNF in Genome Data Viewer
    Location:
    23q22
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current ARS-UCD1.2 (GCF_002263795.1) 23 NC_037350.1 (27716170..27718943, complement)
    105 previous assembly Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 23 AC_000180.1 (27533899..27537807, complement)

    Chromosome 23 - NC_037350.1Genomic Context describing neighboring genes Neighboring gene leukocyte specific transcript 1 Neighboring gene lymphotoxin beta Neighboring gene uncharacterized LOC100847561 Neighboring gene uncharacterized LOC112443855 Neighboring gene lymphotoxin alpha Neighboring gene NFKB inhibitor like 1

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

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    • Adipocytokine signaling pathway, organism-specific biosystem (from KEGG)
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    • Adipocytokine signaling pathway, conserved biosystem (from KEGG)
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    • Allograft Rejection, organism-specific biosystem (from WikiPathways)
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    • Allograft rejection, organism-specific biosystem (from KEGG)
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    • Allograft rejection, conserved biosystem (from KEGG)
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    • Alzheimer's disease, organism-specific biosystem (from KEGG)
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    • Amyotrophic lateral sclerosis (ALS), organism-specific biosystem (from KEGG)
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    • Antigen processing and presentation, conserved biosystem (from KEGG)
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    • Apoptosis, organism-specific biosystem (from KEGG)
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    • Apoptosis-related network due to altered Notch3 in ovarian cancer, organism-specific biosystem (from WikiPathways)
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    • Aryl Hydrocarbon Receptor, organism-specific biosystem (from WikiPathways)
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    • Aryl Hydrocarbon Receptor Pathway, organism-specific biosystem (from WikiPathways)
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    • Asthma, organism-specific biosystem (from KEGG)
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    • Asthma, conserved biosystem (from KEGG)
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    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
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    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
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    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
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    • Cytokines and Inflammatory Response, organism-specific biosystem (from WikiPathways)
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    • Dilated cardiomyopathy, organism-specific biosystem (from KEGG)
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    • Dilated cardiomyopathy, conserved biosystem (from KEGG)
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    • FAS pathway and Stress induction of HSP regulation, organism-specific biosystem (from WikiPathways)
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    • Fc epsilon RI signaling pathway, organism-specific biosystem (from KEGG)
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    • Fc epsilon RI signaling pathway, conserved biosystem (from KEGG)
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    • Fluid shear stress and atherosclerosis, organism-specific biosystem (from KEGG)
      Fluid shear stress and atherosclerosis, organism-specific biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
    • Fluid shear stress and atherosclerosis, conserved biosystem (from KEGG)
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    • Folate Metabolism, organism-specific biosystem (from WikiPathways)
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    • Graft-versus-host disease, organism-specific biosystem (from KEGG)
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    • Graft-versus-host disease, conserved biosystem (from KEGG)
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    • HTLV-I infection, organism-specific biosystem (from KEGG)
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    • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
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    • Hematopoietic cell lineage, conserved biosystem (from KEGG)
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    • Hepatitis B, organism-specific biosystem (from KEGG)
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    • Hepatitis C, organism-specific biosystem (from KEGG)
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    • Hepatitis C, conserved biosystem (from KEGG)
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    • Herpes simplex infection, organism-specific biosystem (from KEGG)
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    • Hypertrophic cardiomyopathy (HCM), organism-specific biosystem (from KEGG)
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    • Hypertrophic cardiomyopathy (HCM), conserved biosystem (from KEGG)
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    • IL-17 signaling pathway, organism-specific biosystem (from KEGG)
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    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
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    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
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    • NOD-like receptor signaling pathway, organism-specific biosystem (from KEGG)
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    • Natural killer cell mediated cytotoxicity, organism-specific biosystem (from KEGG)
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    • Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystem (from KEGG)
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    • Osteoclast differentiation, organism-specific biosystem (from KEGG)
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    • Osteoclast differentiation, conserved biosystem (from KEGG)
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    • Pertussis, organism-specific biosystem (from KEGG)
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    • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
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    • Proteoglycans in cancer, conserved biosystem (from KEGG)
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    • RIG-I-like receptor signaling pathway, organism-specific biosystem (from KEGG)
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    • RIG-I-like receptor signaling pathway, conserved biosystem (from KEGG)
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    • Regulation of TNFR1 signaling, organism-specific biosystem (from REACTOME)
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    • Regulation of toll-like receptor signaling pathway, organism-specific biosystem (from WikiPathways)
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    • Rheumatoid arthritis, organism-specific biosystem (from KEGG)
      Rheumatoid arthritis, organism-specific biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
    • Rheumatoid arthritis, conserved biosystem (from KEGG)
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    • SIDS Susceptibility Pathways, organism-specific biosystem (from WikiPathways)
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    • Selenium Micronutrient Network, organism-specific biosystem (from WikiPathways)
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    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Sphingolipid signaling pathway, organism-specific biosystem (from KEGG)
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    • Sphingolipid signaling pathway, conserved biosystem (from KEGG)
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    • Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
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    • Systemic lupus erythematosus, organism-specific biosystem (from KEGG)
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    • Systemic lupus erythematosus, conserved biosystem (from KEGG)
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    • T cell receptor signaling pathway, organism-specific biosystem (from KEGG)
      T cell receptor signaling pathway, organism-specific biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
    • T cell receptor signaling pathway, conserved biosystem (from KEGG)
      T cell receptor signaling pathway, conserved biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
    • TGF Beta Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TGF Beta Signaling Pathway, organism-specific biosystemThe Transforming growth factor beta (TGFβ) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiat...
    • TGF-beta signaling pathway, organism-specific biosystem (from KEGG)
      TGF-beta signaling pathway, organism-specific biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
    • TGF-beta signaling pathway, conserved biosystem (from KEGG)
      TGF-beta signaling pathway, conserved biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
    • TNF alpha Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TNF alpha Signaling Pathway, organism-specific biosystemTumor necrosis factor alpha (TNF?) is a proinflammatory cytokine involved in various biological processes including regulation of cell proliferation, differentiation, apoptosis and immune response. T...
    • TNF signaling, organism-specific biosystem (from REACTOME)
      TNF signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • TNF signaling pathway, organism-specific biosystem (from KEGG)
      TNF signaling pathway, organism-specific biosystemTumor necrosis factor (TNF), as a critical cytokine, can induce a wide range of intracellular signal pathways including apoptosis and cell survival as well as inflammation and immunity. Activated TNF...
    • TNF signaling pathway, conserved biosystem (from KEGG)
      TNF signaling pathway, conserved biosystemTumor necrosis factor (TNF), as a critical cytokine, can induce a wide range of intracellular signal pathways including apoptosis and cell survival as well as inflammation and immunity. Activated TNF...
    • TNFR1-induced NFkappaB signaling pathway, organism-specific biosystem (from REACTOME)
      TNFR1-induced NFkappaB signaling pathway, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • TNFR1-induced proapoptotic signaling, organism-specific biosystem (from REACTOME)
      TNFR1-induced proapoptotic signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • TNFR1-mediated ceramide production, organism-specific biosystem (from REACTOME)
      TNFR1-mediated ceramide production, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • TNFR2 non-canonical NF-kB pathway, organism-specific biosystem (from REACTOME)
      TNFR2 non-canonical NF-kB pathway, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • TWEAK Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TWEAK Signaling Pathway, organism-specific biosystemTNF related weak inducer of apoptosis (TWEAK) is a small pleiotropic cytokine of the TNF super family and its gene is located at chromosome 17p13.1. TWEAK has been reported to be expressed in tissues...
    • Toll-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
    • Toll-like receptor signaling pathway, conserved biosystem (from KEGG)
      Toll-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
    • Toll-like receptor signaling pathway, organism-specific biosystem (from WikiPathways)
      Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
    • Toxoplasmosis, organism-specific biosystem (from KEGG)
      Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • Toxoplasmosis, conserved biosystem (from KEGG)
      Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • Tuberculosis, organism-specific biosystem (from KEGG)
      Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Tuberculosis, conserved biosystem (from KEGG)
      Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Type I diabetes mellitus, organism-specific biosystem (from KEGG)
      Type I diabetes mellitus, organism-specific biosystemType I diabetes mellitus is a disease that results from autoimmune destruction of the insulin-producing beta-cells. Certain beta-cell proteins act as autoantigens after being processed by antigen-pre...
    • Type I diabetes mellitus, conserved biosystem (from KEGG)
      Type I diabetes mellitus, conserved biosystemType I diabetes mellitus is a disease that results from autoimmune destruction of the insulin-producing beta-cells. Certain beta-cell proteins act as autoantigens after being processed by antigen-pre...
    • Type II diabetes mellitus, organism-specific biosystem (from KEGG)
      Type II diabetes mellitus, organism-specific biosystemInsulin resistance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Ser...
    • Type II diabetes mellitus, conserved biosystem (from KEGG)
      Type II diabetes mellitus, conserved biosystemInsulin resistance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Ser...
    • Type II diabetes mellitus, organism-specific biosystem (from WikiPathways)
      Type II diabetes mellitus, organism-specific biosystemInsulin resistance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Ser...
    • Vitamin B12 Metabolism, organism-specific biosystem (from WikiPathways)
      Vitamin B12 Metabolism, organism-specific biosystem
      Vitamin B12 Metabolism
    • mTOR signaling pathway, organism-specific biosystem (from KEGG)
      mTOR signaling pathway, organism-specific biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...
    • mTOR signaling pathway, conserved biosystem (from KEGG)
      mTOR signaling pathway, conserved biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    protease binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcription regulatory region DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    tumor necrosis factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    JNK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    activation of MAPK activity IEA
    Inferred from Electronic Annotation
    more info
     
    activation of MAPKKK activity IEA
    Inferred from Electronic Annotation
    more info
     
    activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to amino acid stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to nicotine IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to organic cyclic compound IEA
    Inferred from Electronic Annotation
    more info
     
    chronic inflammatory response to antigenic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cortical actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    defense response to Gram-positive bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    embryonic digestive tract development IEA
    Inferred from Electronic Annotation
    more info
     
    endothelial cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    epithelial cell proliferation involved in salivary gland morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular matrix organization IEA
    Inferred from Electronic Annotation
    more info
     
    extrinsic apoptotic signaling pathway via death domain receptors IEA
    Inferred from Electronic Annotation
    more info
     
    glucose metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    humoral immune response IEA
    Inferred from Electronic Annotation
    more info
     
    intrinsic apoptotic signaling pathway in response to DNA damage IEA
    Inferred from Electronic Annotation
    more info
     
    leukocyte tethering or rolling IEA
    Inferred from Electronic Annotation
    more info
     
    lipopolysaccharide-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    necroptotic signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of alkaline phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of bicellular tight junction assembly IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of branching involved in lung morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cytokine secretion involved in immune response IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of endothelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of feeding behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of glucose import IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of growth of symbiont in host IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of interleukin-6 production IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of lactation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of myoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of myosin-light-chain-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of protein complex disassembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of viral genome replication IEA
    Inferred from Electronic Annotation
    more info
     
    osteoclast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of JUN kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of MAP kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of NF-kappaB transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of NIK/NF-kappaB signaling IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of blood microparticle formation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of calcidiol 1-monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of calcineurin-NFAT signaling cascade IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of chemokine (C-X-C motif) ligand 2 production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of chemokine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of chronic inflammatory response to antigenic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cytokine secretion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of fever generation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of glial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of hair follicle development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of heterotypic cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of humoral immune response mediated by circulating immunoglobulin IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of interferon-gamma production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interleukin-6 production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interleukin-8 biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of leukocyte adhesion to arterial endothelial cell IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of membrane protein ectodomain proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of nitric oxide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of osteoclast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of peptidyl-serine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of phagocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of plasminogen activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of podosome assembly IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein complex disassembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of protein kinase B signaling IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein localization to cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein localization to plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of superoxide dismutase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of translational initiation by iron IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of triglyceride metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of vascular smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    production of molecular mediator involved in inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein import into nucleus, translocation IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase B signaling IEA
    Inferred from Electronic Annotation
    more info
     
    protein localization to plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    receptor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of branching involved in salivary gland morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of endothelial cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of establishment of endothelial barrier IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of immunoglobulin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of insulin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of synapse organization IEA
    Inferred from Electronic Annotation
    more info
     
    response to glucocorticoid IEA
    Inferred from Electronic Annotation
    more info
     
    response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    sequestering of triglyceride IEA
    Inferred from Electronic Annotation
    more info
     
    tumor necrosis factor-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space NAS
    Non-traceable Author Statement
    more info
    PubMed 
    integral component of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane raft IEA
    Inferred from Electronic Annotation
    more info
     
    phagocytic cup IEA
    Inferred from Electronic Annotation
    more info
     
    recycling endosome IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    tumor necrosis factor
    Names
    cachectin
    tumor necrosis factor alpha
    tumor necrosis factor ligand superfamily member 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173966.3NP_776391.2  tumor necrosis factor

      See identical proteins and their annotated locations for NP_776391.2

      Status: PROVISIONAL

      Source sequence(s)
      BC134755
      UniProtKB/Swiss-Prot
      Q06599
      Related
      ENSBTAP00000035682.3, ENSBTAT00000035815.3
      Conserved Domains (1) summary
      pfam00229
      Location:103234
      TNF; TNF(tumor Necrosis Factor) family

    RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD1.2 Primary Assembly

    Genomic

    1. NC_037350.1 Reference ARS-UCD1.2 Primary Assembly

      Range
      27716170..27718943 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005223596.4XP_005223653.4  tumor necrosis factor isoform X1

      Conserved Domains (1) summary
      pfam00229
      Location:102233
      TNF; TNF(tumor Necrosis Factor) family
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