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    INS insulin [ Bos taurus (cattle) ]

    Gene ID: 280829, updated on 5-Mar-2024

    Summary

    Official Symbol
    INSprovided by VGNC
    Official Full Name
    insulinprovided by VGNC
    Primary source
    VGNC:VGNC:56268
    See related
    BGD:BT10074; Ensembl:ENSBTAG00000013003
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
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    Genomic context

    See INS in Genome Data Viewer
    Location:
    chromosome: 29
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 29 NC_037356.1 (49393375..49394536)

    Chromosome 29 - NC_037356.1Genomic Context describing neighboring genes Neighboring gene achaete-scute family bHLH transcription factor 2 Neighboring gene tyrosine hydroxylase Neighboring gene insulin like growth factor 2 Neighboring gene microRNA mir-483 Neighboring gene uncharacterized LOC132344217

    Genomic regions, transcripts, and products

    Genomic Sequence:
    NC_037356.1 Chromosome 29 Reference ARS-UCD2.0 Primary Assembly

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC159719

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in glucose homeostasis IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    involved_in positive regulation of protein secretion IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001185126.1NP_001172055.1  insulin preproprotein

      See identical proteins and their annotated locations for NP_001172055.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      EH379095, EV652245
      UniProtKB/Swiss-Prot
      P01317
      UniProtKB/TrEMBL
      A5PJB2
      Related
      ENSBTAP00000017289.4, ENSBTAT00000017289.5
      Conserved Domains (1) summary
      cd04367
      Location:26105
      IlGF_insulin_like; IlGF_like family, insulin_like subgroup, specific to vertebrates. Members include a number of peptides including insulin and insulin-like growth factors I and II, which play a variety of roles in controlling processes such as metabolism, growth and ...
    2. NM_173926.2NP_776351.2  insulin preproprotein

      See identical proteins and their annotated locations for NP_776351.2

      Status: VALIDATED

      Description
      Transcript Variant: This transcript (1) represents the shorter variant. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      EV652245
      UniProtKB/Swiss-Prot
      P01317
      UniProtKB/TrEMBL
      A5PJB2
      Conserved Domains (1) summary
      cd04367
      Location:26105
      IlGF_insulin_like; IlGF_like family, insulin_like subgroup, specific to vertebrates. Members include a number of peptides including insulin and insulin-like growth factors I and II, which play a variety of roles in controlling processes such as metabolism, growth and ...

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037356.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      49393375..49394536
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)