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    Desi1 desumoylating isopeptidase 1 [ Mus musculus (house mouse) ]

    Gene ID: 28075, updated on 23-Jun-2021

    Summary

    Official Symbol
    Desi1provided by MGI
    Official Full Name
    desumoylating isopeptidase 1provided by MGI
    Primary source
    MGI:MGI:106313
    See related
    Ensembl:ENSMUSG00000022472
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ppp; DeSI-1; Fam152; Pppde2; Fam152b; AI427858; AI850401; D15Wsu75; D15Wsu75e
    Expression
    Broad expression in testis adult (RPKM 105.5), thymus adult (RPKM 62.0) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Desi1 in Genome Data Viewer
    Location:
    15 E1; 15 38.34 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (81876724..81900424, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (81992523..82016258, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (81822953..81846570, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S14 Neighboring gene NADH:ubiquinone oxidoreductase subunit B11B Neighboring gene X-ray repair complementing defective repair in Chinese hamster cells 6 Neighboring gene SNU13 homolog, small nuclear ribonucleoprotein (U4/U6.U5) Neighboring gene RIKEN cDNA 4930407I10 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SUMO-specific isopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables importin-alpha family protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in protein desumoylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein modification by small protein removal IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    desumoylating isopeptidase 1
    Names
    PPPDE peptidase domain containing 2
    PPPDE peptidase domain-containing protein 2
    family with sequence similarity 152, member B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356541.1NP_001343470.1  desumoylating isopeptidase 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC102176
      Conserved Domains (1) summary
      pfam05903
      Location:7148
      Peptidase_C97; PPPDE putative peptidase domain
    2. NM_134095.3NP_598856.1  desumoylating isopeptidase 1 isoform 1

      See identical proteins and their annotated locations for NP_598856.1

      Status: VALIDATED

      Source sequence(s)
      AC102176
      Consensus CDS
      CCDS27681.1
      UniProtKB/Swiss-Prot
      Q9CQT7
      Related
      ENSMUSP00000121504.2, ENSMUST00000152227.8
      Conserved Domains (1) summary
      pfam05903
      Location:7149
      Peptidase_C97; PPPDE putative peptidase domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      81876724..81900424 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_384015.5 RNA Sequence

      Related
      ENSMUST00000146628.8
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