Format

Send to:

Choose Destination
    • Showing Current items.

    Adam1a a disintegrin and metallopeptidase domain 1a [ Mus musculus (house mouse) ]

    Gene ID: 280668, updated on 16-Oct-2021

    Summary

    Official Symbol
    Adam1aprovided by MGI
    Official Full Name
    a disintegrin and metallopeptidase domain 1aprovided by MGI
    Primary source
    MGI:MGI:2429504
    See related
    Ensembl:ENSMUSG00000072647
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ftna; Adam1
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Adam1a in Genome Data Viewer
    Location:
    5 F; 5 61.84 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (121656667..121659758, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (121518604..121521695, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (121968613..121971704, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 116 Neighboring gene mitogen-activated protein kinase 3 pseudogene Neighboring gene a disintegrin and metallopeptidase domain 1b Neighboring gene MAP kinase-activated protein kinase 5 Neighboring gene aldehyde dehydrogenase 2, mitochondrial

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metallopeptidase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in binding of sperm to zona pellucida IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within binding of sperm to zona pellucida IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in fusion of sperm to egg plasma membrane involved in single fertilization NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in male gonad development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in proteolysis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in integral component of membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 1a
    Names
    ADAM 1a
    PH-30 alpha
    a disintegrin and metalloproteinase domain 1a (fertilin alpha)
    fertilin alpha
    fertilin subunit alpha-a

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172126.2NP_742124.2  disintegrin and metalloproteinase domain-containing protein 1a precursor

      See identical proteins and their annotated locations for NP_742124.2

      Status: PROVISIONAL

      Source sequence(s)
      BC052093
      Consensus CDS
      CCDS19637.1
      UniProtKB/Swiss-Prot
      Q60813
      UniProtKB/TrEMBL
      Q3V0H1
      Related
      ENSMUSP00000098320.5, ENSMUST00000100757.6
      Conserved Domains (5) summary
      smart00050
      Location:447519
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:521657
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:235427
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam01421
      Location:235429
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:95190
      Pep_M12B_propep; Reprolysin family propeptide

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      121656667..121659758 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center