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    Kiss1 KiSS-1 metastasis-suppressor [ Mus musculus (house mouse) ]

    Gene ID: 280287, updated on 1-Jul-2024

    Summary

    Official Symbol
    Kiss1provided by MGI
    Official Full Name
    KiSS-1 metastasis-suppressorprovided by MGI
    Primary source
    MGI:MGI:2663985
    See related
    Ensembl:ENSMUSG00000115958 Ensembl:ENSMUSG00000116158 AllianceGenome:MGI:2663985
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    kisspeptin; metastatin
    Summary
    Predicted to enable kisspeptin receptor binding activity. Acts upstream of or within several processes, including G protein-coupled receptor signaling pathway; decidualization; and negative regulation of cell migration. Predicted to be located in several cellular components, including apical plasma membrane; extracellular space; and neuronal cell body. Predicted to be active in neuron projection. Is expressed in diencephalon and metanephros. Used to study hypogonadotropic hypogonadism 13 with or without anosmia. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 13 with or without anosmia. Orthologous to human KISS1 (KiSS-1 metastasis suppressor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in large intestine adult (RPKM 7.1), genital fat pad adult (RPKM 4.0) and 12 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Kiss1 in Genome Data Viewer
    Location:
    1 E4; 1 57.91 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (133249625..133257460)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (133321887..133329722)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene pleckstrin homology domain containing, family A member 6 Neighboring gene predicted gene, 19461 Neighboring gene STARR-seq mESC enhancer starr_02280 Neighboring gene golgi transport 1A Neighboring gene predicted gene, 53474 Neighboring gene Ren1 promoter and enhancer region Neighboring gene STARR-positive B cell enhancer ABC_E11089 Neighboring gene renin 1 structural Neighboring gene ethanolamine kinase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables kisspeptin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables kisspeptin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within decidualization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in generation of ovulation cycle rhythm ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of cell migration IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of cell population proliferation IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of growth hormone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of luteinizing hormone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    metastasis-suppressor KiSS-1
    Names
    0610012C01Rik
    Kiss1 metastasis-suppressor
    kisspeptin-1
    metastin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001412624.1NP_001399553.1  metastasis-suppressor KiSS-1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC068906
      UniProtKB/Swiss-Prot
      Q149Z8, Q68Y93, Q6Y4S4, Q80XF6
      UniProtKB/TrEMBL
      I0J0X7
      Related
      ENSMUSP00000136746.2, ENSMUST00000178033.5
    2. NM_178260.4NP_839991.2  metastasis-suppressor KiSS-1 precursor

      See identical proteins and their annotated locations for NP_839991.2

      Status: VALIDATED

      Source sequence(s)
      AC068906
      Consensus CDS
      CCDS48362.1
      UniProtKB/Swiss-Prot
      Q149Z8, Q68Y93, Q6Y4S4, Q80XF6
      UniProtKB/TrEMBL
      I0J0X7
      Related
      ENSMUSP00000142264.2, ENSMUST00000195286.5
      Conserved Domains (1) summary
      pfam15152
      Location:42116
      Kisspeptin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      133249625..133257460
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529682.2XP_006529745.1  metastasis-suppressor KiSS-1 isoform X4

      UniProtKB/Swiss-Prot
      Q149Z8, Q68Y93, Q6Y4S4, Q80XF6
      Conserved Domains (1) summary
      pfam15152
      Location:68142
      Kisspeptin
    2. XM_006529681.1XP_006529744.1  metastasis-suppressor KiSS-1 isoform X3

      Conserved Domains (1) summary
      pfam15152
      Location:93167
      Kisspeptin
    3. XM_030254793.1XP_030110653.1  metastasis-suppressor KiSS-1 isoform X5

      UniProtKB/Swiss-Prot
      Q149Z8, Q68Y93, Q6Y4S4, Q80XF6
      UniProtKB/TrEMBL
      I0J0X7
      Conserved Domains (1) summary
      pfam15152
      Location:42116
      Kisspeptin