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    Ing4 inhibitor of growth family, member 4 [ Mus musculus (house mouse) ]

    Gene ID: 28019, updated on 3-Oct-2018

    Summary

    Official Symbol
    Ing4provided by MGI
    Official Full Name
    inhibitor of growth family, member 4provided by MGI
    Primary source
    MGI:MGI:107307
    See related
    Ensembl:ENSMUSG00000030330 Vega:OTTMUSG00000024325
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D6Xrf92; p29ING4; D6Wsu147e
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 43.3), CNS E14 (RPKM 42.0) and 28 other tissues See more
    Orthologs

    Genomic context

    See Ing4 in Genome Data Viewer
    Location:
    6 F2; 6 59.17 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (125039848..125049264)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (124989866..124999282)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 40398 Neighboring gene PILR alpha associated neural protein Neighboring gene RIKEN cDNA 4930557K07 gene Neighboring gene zinc finger protein 384 Neighboring gene proacrosin binding protein Neighboring gene lysophosphatidic acid receptor 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell cycle arrest ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    histone H3 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    histone H4-K12 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    histone H4-K5 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    histone H4-K8 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    histone acetylation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of growth ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    protein acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    intermediate filament cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    inhibitor of growth protein 4
    Names
    ING1-like protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133345.2NP_579923.1  inhibitor of growth protein 4

      See identical proteins and their annotated locations for NP_579923.1

      Status: PROVISIONAL

      Source sequence(s)
      AK009267
      Consensus CDS
      CCDS39632.1
      UniProtKB/Swiss-Prot
      Q8C0D7
      Related
      ENSMUSP00000032480.7, OTTMUSP00000029000, ENSMUST00000032480.13, OTTMUST00000059591
      Conserved Domains (2) summary
      cd15684
      Location:196243
      PHD_ING4; PHD finger found in inhibitor of growth protein 4 (ING4)
      pfam12998
      Location:6105
      ING; Inhibitor of growth proteins N-terminal histone-binding

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      125039848..125049264
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_144510.1: Suppressed sequence

      Description
      NM_144510.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
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