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    Ing4 inhibitor of growth family, member 4 [ Mus musculus (house mouse) ]

    Gene ID: 28019, updated on 26-Sep-2022

    Summary

    Official Symbol
    Ing4provided by MGI
    Official Full Name
    inhibitor of growth family, member 4provided by MGI
    Primary source
    MGI:MGI:107307
    See related
    Ensembl:ENSMUSG00000030330 AllianceGenome:MGI:107307
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D6Xrf92; p29ING4; D6Wsu147e
    Summary
    Predicted to enable methylated histone binding activity and transcription coactivator activity. Involved in positive regulation of apoptotic process. Located in nucleus. Is expressed in several structures, including cerebral cortex; early conceptus; genitourinary system; sensory organ; and skeleton. Orthologous to human ING4 (inhibitor of growth family member 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 43.3), CNS E14 (RPKM 42.0) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ing4 in Genome Data Viewer
    Location:
    6 F2; 6 59.17 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (125016811..125026228)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (125039848..125049265)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene COP9 signalosome subunit 7A Neighboring gene RIKEN cDNA 4930557K07 gene Neighboring gene PILR alpha associated neural protein Neighboring gene zinc finger protein 384 Neighboring gene proacrosin binding protein Neighboring gene lysophosphatidic acid receptor 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleic acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in histone H3 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histone H4-K12 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histone H4-K5 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histone H4-K8 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histone acetylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in histone modification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of DNA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_negative_effect regulation of cell cycle G2/M phase transition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of MOZ/MORF histone acetyltransferase complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intermediate filament cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    inhibitor of growth protein 4
    Names
    ING1-like protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368695.1NP_001355624.1  inhibitor of growth protein 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC134529
      Consensus CDS
      CCDS90121.1
      UniProtKB/Swiss-Prot
      Q9D7F9
      UniProtKB/TrEMBL
      A0A6P5PV07, A0A8C6GJB8
      Related
      ENSMUSP00000121519.2, ENSMUST00000140131.8
      Conserved Domains (2) summary
      COG5034
      Location:7245
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd16862
      Location:11104
      ING_ING4; Inhibitor of growth (ING) domain of inhibitor of growth protein 4 (ING4)
    2. NM_133345.2NP_579923.1  inhibitor of growth protein 4 isoform 1

      See identical proteins and their annotated locations for NP_579923.1

      Status: VALIDATED

      Source sequence(s)
      AK009267
      Consensus CDS
      CCDS39632.1
      UniProtKB/Swiss-Prot
      Q8C0D7
      UniProtKB/TrEMBL
      A0A6P5PPQ9
      Related
      ENSMUSP00000032480.8, ENSMUST00000032480.14
      Conserved Domains (2) summary
      COG5034
      Location:7244
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd16862
      Location:11104
      ING_ING4; Inhibitor of growth (ING) domain of inhibitor of growth protein 4 (ING4)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      125016811..125026228
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_144510.1: Suppressed sequence

      Description
      NM_144510.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.