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    Polr2m polymerase (RNA) II (DNA directed) polypeptide M [ Mus musculus (house mouse) ]

    Gene ID: 28015, updated on 23-Jun-2021

    Summary

    Official Symbol
    Polr2mprovided by MGI
    Official Full Name
    polymerase (RNA) II (DNA directed) polypeptide Mprovided by MGI
    Primary source
    MGI:MGI:107282
    See related
    Ensembl:ENSMUSG00000032199
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gr; Grinl1a; AA407243; AA408799; AI303746; AW553238; D9Wsu138; D9Wsu138e; mKIAA4185
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 79.8), limb E14.5 (RPKM 68.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Polr2m in Genome Data Viewer
    Location:
    9 D; 9 39.85 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (71385719..71393265, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (71478437..71485983, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (71326244..71333790, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene aldehyde dehydrogenase family 1, subfamily A2 Neighboring gene predicted gene, 32769 Neighboring gene myocardial zonula adherens protein Neighboring gene MAD1 mitotic arrest deficient 1-like 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA4185

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-directed 5'-3' RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in maintenance of ER location IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in maintenance of ER location IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of RNA polymerase II, core complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of RNA polymerase II, holoenzyme IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of RNA polymerase II, holoenzyme ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in intracellular anatomical structure IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in neuronal cell body IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    DNA-directed RNA polymerase II subunit GRINL1A
    Names
    DNA-directed RNA polymerase II subunit M
    glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A
    glutamate receptor-like protein 1A
    protein GRINL1A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164793.1NP_001158265.1  DNA-directed RNA polymerase II subunit GRINL1A isoform 2

      See identical proteins and their annotated locations for NP_001158265.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AK002571, BE993895
      Consensus CDS
      CCDS52853.1
      UniProtKB/Swiss-Prot
      Q6P6I6
      Related
      ENSMUSP00000132335.2, ENSMUST00000163972.2
      Conserved Domains (1) summary
      pfam15328
      Location:1135
      GCOM2; Putative GRINL1B complex locus protein 2
    2. NM_178602.3NP_848717.1  DNA-directed RNA polymerase II subunit GRINL1A isoform 1

      See identical proteins and their annotated locations for NP_848717.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK052037, BE993895, BQ443340
      Consensus CDS
      CCDS23326.1
      UniProtKB/Swiss-Prot
      Q6P6I6
      Related
      ENSMUSP00000034720.6, ENSMUST00000034720.12
      Conserved Domains (1) summary
      pfam15328
      Location:37239
      GCOM2; Putative GRINL1B complex locus protein 2

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      71385719..71393265 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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