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    Vkorc1 vitamin K epoxide reductase complex, subunit 1 [ Mus musculus (house mouse) ]

    Gene ID: 27973, updated on 22-Aug-2021

    Summary

    Official Symbol
    Vkorc1provided by MGI
    Official Full Name
    vitamin K epoxide reductase complex, subunit 1provided by MGI
    Primary source
    MGI:MGI:106442
    See related
    Ensembl:ENSMUSG00000096145
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D7Wsu86; D7Wsu86e
    Summary
    Vitamin K is essential for blood clotting but must be enzymatically activated. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. The product of this gene encodes the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is the product of this gene that is sensitive to warfarin. In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors and, in humans and rats, with warfarin resistance. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in liver adult (RPKM 270.9), liver E18 (RPKM 177.3) and 23 other tissues See more
    Orthologs
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    Genomic context

    See Vkorc1 in Genome Data Viewer
    Location:
    7 F3; 7 69.81 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (127492235..127494833, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (127893063..127895658, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (135036577..135039131, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 668 Neighboring gene zinc finger protein 646 Neighboring gene protease, serine 53 Neighboring gene branched chain ketoacid dehydrogenase kinase Neighboring gene K(lysine) acetyltransferase 8 Neighboring gene protease, serine 8 (prostasin)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in blood coagulation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in blood coagulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in blood coagulation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in bone development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptidyl-glutamic acid carboxylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in peptidyl-glutamic acid carboxylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of coagulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of blood coagulation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to antibiotic ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to organonitrogen compound ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within vitamin K biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in vitamin K metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within vitamin K metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in vitamin K metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vitamin K metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in xenobiotic metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    vitamin K epoxide reductase complex subunit 1
    Names
    phylloquinone epoxide reductase
    vitamin K 2,3-epoxide reductase complex subunit 1
    vitamin K epoxide reductase subunit I
    vitamin K1 2,3-epoxide reductase subunit 1
    vitamin K1 epoxide reductase (warfarin-sensitive)
    NP_848715.1
    XP_030098508.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178600.2NP_848715.1  vitamin K epoxide reductase complex subunit 1 precursor

      See identical proteins and their annotated locations for NP_848715.1

      Status: REVIEWED

      Source sequence(s)
      AK003237, CD774913
      Consensus CDS
      CCDS21883.1
      UniProtKB/Swiss-Prot
      Q9CRC0
      Related
      ENSMUSP00000033074.7, ENSMUST00000033074.8
      Conserved Domains (1) summary
      cd12917
      Location:25149
      VKOR_euk; Vitamin K epoxide reductase family in eukaryotes, excluding plants

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      127492235..127494833 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242648.2XP_030098508.1  vitamin K epoxide reductase complex subunit 1 isoform X1

      Conserved Domains (1) summary
      cl01729
      Location:2558
      VKOR; Vitamin K epoxide reductase (VKOR) family
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