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    GNG5 G protein subunit gamma 5 [ Homo sapiens (human) ]

    Gene ID: 2787, updated on 9-Jun-2024

    Summary

    Official Symbol
    GNG5provided by HGNC
    Official Full Name
    G protein subunit gamma 5provided by HGNC
    Primary source
    HGNC:HGNC:4408
    See related
    Ensembl:ENSG00000174021 MIM:600874; AllianceGenome:HGNC:4408
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    G proteins are trimeric (alpha-beta-gamma) membrane-associated proteins that regulate flow of information from cell surface receptors to a variety of internal metabolic effectors. Interaction of a G protein with its activated receptor promotes exchange of GTP for GDP that is bound to the alpha subunit. The alpha-GTP complex dissociates from the beta-gamma heterodimer so that the subunits, in turn, may interact with and regulate effector molecules (Gilman, 1987 [PubMed 3113327]; summary by Ahmad et al., 1995) [PubMed 7606925].[supplied by OMIM, Nov 2010]
    Expression
    Ubiquitous expression in colon (RPKM 64.2), bone marrow (RPKM 52.7) and 25 other tissues See more
    Orthologs
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    Genomic context

    See GNG5 in Genome Data Viewer
    Location:
    1p22.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (84498325..84506581, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (84338707..84346962, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (84964008..84972264, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:84830842-84832041 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1249 Neighboring gene urate oxidase (pseudogene) Neighboring gene Sharpr-MPRA regulatory region 5400 Neighboring gene deoxyribonuclease 2 beta Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1250 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:84944610-84945170 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1251 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1252 Neighboring gene NANOG hESC enhancer GRCh37_chr1:84969365-84969870 Neighboring gene ribosome production factor 1 homolog Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1019 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1020 Neighboring gene spermatogenesis associated 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1253 Neighboring gene chitobiase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1254 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1255 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1021 Neighboring gene uncharacterized LOC105378819 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:85044029-85044228

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    General protein information

    Preferred Names
    guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
    Names
    guanine nucleotide binding protein (G protein), gamma 5
    NP_005265.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005274.3NP_005265.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5

      See identical proteins and their annotated locations for NP_005265.1

      Status: VALIDATED

      Source sequence(s)
      AL359762, BC003563, BM809260, BM834854
      Consensus CDS
      CCDS696.1
      UniProtKB/Swiss-Prot
      B2R5A0, P30670, P63218, Q5VX54, Q61015
      Related
      ENSP00000359679.4, ENST00000370645.9
      Conserved Domains (1) summary
      cd00068
      Location:763
      GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      84498325..84506581 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      84338707..84346962 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)