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    Depdc5 DEP domain containing 5 [ Mus musculus (house mouse) ]

    Gene ID: 277854, updated on 31-Jan-2019

    Summary

    Official Symbol
    Depdc5provided by MGI
    Official Full Name
    DEP domain containing 5provided by MGI
    Primary source
    MGI:MGI:2141101
    See related
    Ensembl:ENSMUSG00000037426
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AV016528
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 5.6), whole brain E14.5 (RPKM 5.6) and 28 other tissues See more
    Orthologs

    Genomic context

    See Depdc5 in Genome Data Viewer
    Location:
    5 B1; 5 17.35 cM
    Exon count:
    46
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (32863645..32994233)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (33206370..33336882)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene predicted gene 2420 Neighboring gene phosphatidylserine decarboxylase Neighboring gene proline rich 14-like Neighboring gene ribosomal protein L37 pseudogene Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide Neighboring gene predicted gene, 29892

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3) 
    • Chemically induced (ENU) (2) 
    • Endonuclease-mediated (1)  1 citation

    Pathways from BioSystems

    • mTOR signaling pathway, organism-specific biosystem (from KEGG)
      mTOR signaling pathway, organism-specific biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...
    • mTOR signaling pathway, conserved biosystem (from KEGG)
      mTOR signaling pathway, conserved biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0645

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cellular response to amino acid starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular response to amino acid starvation ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of TOR signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    colocalizes_with Cul3-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    GATOR1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    GATOR1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    GATOR complex protein DEPDC5; DEP domain-containing protein 5

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025426.2NP_001020597.1  GATOR complex protein DEPDC5 isoform 1

      See identical proteins and their annotated locations for NP_001020597.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
      Source sequence(s)
      AC122203, BC072604
      Consensus CDS
      CCDS19196.1
      UniProtKB/TrEMBL
      Q6GQV2
      Related
      ENSMUSP00000085207.4, ENSMUST00000087897.10
      Conserved Domains (2) summary
      cd04449
      Location:11761257
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:107381
      DUF3608; Protein of unknown function (DUF3608)
    2. NM_001170567.1NP_001164038.1  GATOR complex protein DEPDC5 isoform 3

      See identical proteins and their annotated locations for NP_001164038.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, uses an alternate in-frame splice site and includes an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is longer than isoform 1.
      Source sequence(s)
      AC122203, AK052458, BC072604, CX568961
      Consensus CDS
      CCDS51463.1
      UniProtKB/Swiss-Prot
      P61460
      UniProtKB/TrEMBL
      Q6GQV2
      Related
      ENSMUSP00000113862.1, ENSMUST00000119705.7
      Conserved Domains (2) summary
      cd04449
      Location:11671248
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:107381
      DUF3608; Protein of unknown function (DUF3608)
    3. NM_001360014.1NP_001346943.1  GATOR complex protein DEPDC5 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' and 3' UTRs and lacks three alternate exons compared to variant 1. The resulting isoform (4) is shorter at the N-terminus, has a shorter and distinct C-terminus, and lacks an alternate internal segment compared to isoform 1.
      Source sequence(s)
      AC108773, AC122203
      Conserved Domains (2) summary
      cd04449
      Location:9761057
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:1212
      IML1; Vacuolar membrane-associated protein Iml1
    4. NM_177786.4NP_808454.2  GATOR complex protein DEPDC5 isoform 2

      See identical proteins and their annotated locations for NP_808454.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC122203, AK078771, AK136321, BC072604
      Consensus CDS
      CCDS19197.1
      UniProtKB/TrEMBL
      E9QAT3, Q6GQV2, Q8BVE2
      Related
      ENSMUSP00000052807.6, ENSMUST00000049780.12
      Conserved Domains (1) summary
      pfam12257
      Location:107381
      DUF3608; Protein of unknown function (DUF3608)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      32863645..32994233
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503983.3XP_006504046.1  DEP domain-containing protein 5 isoform X1

      See identical proteins and their annotated locations for XP_006504046.1

      Conserved Domains (2) summary
      cd04449
      Location:11761257
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:107381
      DUF3608; Protein of unknown function (DUF3608)
    2. XM_006503980.3XP_006504043.1  DEP domain-containing protein 5 isoform X1

      See identical proteins and their annotated locations for XP_006504043.1

      Conserved Domains (2) summary
      cd04449
      Location:11761257
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:107381
      DUF3608; Protein of unknown function (DUF3608)
    3. XM_006503981.3XP_006504044.1  DEP domain-containing protein 5 isoform X1

      See identical proteins and their annotated locations for XP_006504044.1

      Conserved Domains (2) summary
      cd04449
      Location:11761257
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:107381
      DUF3608; Protein of unknown function (DUF3608)
    4. XM_017320910.1XP_017176399.1  DEP domain-containing protein 5 isoform X8

    5. XM_006503986.3XP_006504049.1  DEP domain-containing protein 5 isoform X4

      Conserved Domains (2) summary
      cd04449
      Location:11541235
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:107381
      DUF3608; Protein of unknown function (DUF3608)
    6. XM_006503978.3XP_006504041.1  DEP domain-containing protein 5 isoform X1

      See identical proteins and their annotated locations for XP_006504041.1

      Conserved Domains (2) summary
      cd04449
      Location:11761257
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:107381
      DUF3608; Protein of unknown function (DUF3608)
    7. XM_006503985.3XP_006504048.1  DEP domain-containing protein 5 isoform X3

      Conserved Domains (2) summary
      cd04449
      Location:11541235
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:107381
      DUF3608; Protein of unknown function (DUF3608)
    8. XM_006503984.3XP_006504047.1  DEP domain-containing protein 5 isoform X2

      See identical proteins and their annotated locations for XP_006504047.1

      UniProtKB/Swiss-Prot
      P61460
      Conserved Domains (2) summary
      cd04449
      Location:11671248
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:107381
      DUF3608; Protein of unknown function (DUF3608)
    9. XM_006503987.3XP_006504050.1  DEP domain-containing protein 5 isoform X5

      UniProtKB/Swiss-Prot
      P61460
      Related
      ENSMUSP00000113980.1, ENSMUST00000120902.7
      Conserved Domains (2) summary
      cd04449
      Location:11451226
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:107381
      DUF3608; Protein of unknown function (DUF3608)
    10. XM_006503979.3XP_006504042.1  DEP domain-containing protein 5 isoform X1

      See identical proteins and their annotated locations for XP_006504042.1

      Conserved Domains (2) summary
      cd04449
      Location:11761257
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:107381
      DUF3608; Protein of unknown function (DUF3608)
    11. XM_006503982.3XP_006504045.1  DEP domain-containing protein 5 isoform X1

      See identical proteins and their annotated locations for XP_006504045.1

      Conserved Domains (2) summary
      cd04449
      Location:11761257
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:107381
      DUF3608; Protein of unknown function (DUF3608)
    12. XM_006503988.3XP_006504051.1  DEP domain-containing protein 5 isoform X6

      Conserved Domains (2) summary
      cd04449
      Location:10071088
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:1212
      DUF3608; Protein of unknown function (DUF3608)
    13. XM_006503989.3XP_006504052.1  DEP domain-containing protein 5 isoform X7

      Conserved Domains (2) summary
      cd04449
      Location:9761057
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:1212
      IML1; Vacuolar membrane-associated protein Iml1
    14. XM_017320908.1XP_017176397.1  DEP domain-containing protein 5 isoform X1

      Conserved Domains (2) summary
      cd04449
      Location:11761257
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:107381
      DUF3608; Protein of unknown function (DUF3608)
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