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    Depdc5 DEP domain containing 5 [ Mus musculus (house mouse) ]

    Gene ID: 277854, updated on 7-Aug-2021

    Summary

    Official Symbol
    Depdc5provided by MGI
    Official Full Name
    DEP domain containing 5provided by MGI
    Primary source
    MGI:MGI:2141101
    See related
    Ensembl:ENSMUSG00000037426
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AV016528
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 5.6), whole brain E14.5 (RPKM 5.6) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Depdc5 in Genome Data Viewer
    Location:
    5 B1; 5 17.35 cM
    Exon count:
    45
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (33020989..33151577)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (32863646..32994233)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (33206370..33336882)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene 2420 Neighboring gene phosphatidylserine decarboxylase Neighboring gene proline rich 14-like Neighboring gene ribosomal protein L37 pseudogene Neighboring gene predicted gene, 24003 Neighboring gene uncharacterized LOC118568784 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide Neighboring gene predicted gene, 29892

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3) 
    • Chemically induced (ENU) (2) 
    • Endonuclease-mediated (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0645

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to amino acid starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cellular response to amino acid starvation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of TOR signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of GATOR1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of GATOR1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    GATOR complex protein DEPDC5
    Names
    DEP domain-containing protein 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025426.2NP_001020597.1  GATOR complex protein DEPDC5 isoform 1

      See identical proteins and their annotated locations for NP_001020597.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
      Source sequence(s)
      AC122203, BC072604
      Consensus CDS
      CCDS19196.1
      UniProtKB/TrEMBL
      Q6GQV2
      Related
      ENSMUSP00000085207.5, ENSMUST00000087897.11
      Conserved Domains (2) summary
      cd04449
      Location:11761257
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:101381
      IML1; Vacuolar membrane-associated protein Iml1
    2. NM_001170567.1NP_001164038.1  GATOR complex protein DEPDC5 isoform 3

      See identical proteins and their annotated locations for NP_001164038.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, uses an alternate in-frame splice site and includes an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is longer than isoform 1.
      Source sequence(s)
      AC122203, AK052458, BC072604, CX568961
      Consensus CDS
      CCDS51463.1
      UniProtKB/Swiss-Prot
      P61460
      UniProtKB/TrEMBL
      Q6GQV2
      Related
      ENSMUSP00000113862.2, ENSMUST00000119705.8
      Conserved Domains (2) summary
      cd04449
      Location:11671248
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:101381
      IML1; Vacuolar membrane-associated protein Iml1
    3. NM_001360014.1NP_001346943.1  GATOR complex protein DEPDC5 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' and 3' UTRs and lacks three alternate exons compared to variant 1. The resulting isoform (4) is shorter at the N-terminus, has a shorter and distinct C-terminus, and lacks an alternate internal segment compared to isoform 1.
      Source sequence(s)
      AC108773, AC122203
      Conserved Domains (2) summary
      cd04449
      Location:9761057
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:1212
      IML1; Vacuolar membrane-associated protein Iml1
    4. NM_177786.4NP_808454.2  GATOR complex protein DEPDC5 isoform 2

      See identical proteins and their annotated locations for NP_808454.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC122203, AK078771, AK136321, BC072604
      Consensus CDS
      CCDS19197.1
      UniProtKB/TrEMBL
      E9QAT3, Q6GQV2, Q8BVE2
      Related
      ENSMUSP00000052807.7, ENSMUST00000049780.13
      Conserved Domains (1) summary
      pfam12257
      Location:107381
      DUF3608; Protein of unknown function (DUF3608)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      33020989..33151577
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503983.5XP_006504046.1  GATOR complex protein DEPDC5 isoform X1

      See identical proteins and their annotated locations for XP_006504046.1

      Conserved Domains (2) summary
      cd04449
      Location:11761257
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:101381
      IML1; Vacuolar membrane-associated protein Iml1
    2. XM_036165160.1XP_036021053.1  GATOR complex protein DEPDC5 isoform X2

      Conserved Domains (2) summary
      cd04449
      Location:11671248
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:101381
      IML1; Vacuolar membrane-associated protein Iml1
    3. XM_036165164.1XP_036021057.1  GATOR complex protein DEPDC5 isoform X7

      Conserved Domains (2) summary
      cd04449
      Location:11671248
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:101381
      IML1; Vacuolar membrane-associated protein Iml1
    4. XM_006503980.4XP_006504043.1  GATOR complex protein DEPDC5 isoform X1

      See identical proteins and their annotated locations for XP_006504043.1

      Conserved Domains (2) summary
      cd04449
      Location:11761257
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:101381
      IML1; Vacuolar membrane-associated protein Iml1
    5. XM_030254553.1XP_030110413.1  GATOR complex protein DEPDC5 isoform X8

      Conserved Domains (2) summary
      cd04449
      Location:10071088
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:1212
      IML1; Vacuolar membrane-associated protein Iml1
    6. XM_006503981.4XP_006504044.1  GATOR complex protein DEPDC5 isoform X1

      See identical proteins and their annotated locations for XP_006504044.1

      Conserved Domains (2) summary
      cd04449
      Location:11761257
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:101381
      IML1; Vacuolar membrane-associated protein Iml1
    7. XM_036165161.1XP_036021054.1  GATOR complex protein DEPDC5 isoform X3

      Conserved Domains (2) summary
      cd04449
      Location:11541235
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:101381
      IML1; Vacuolar membrane-associated protein Iml1
    8. XM_030254550.1XP_030110410.1  GATOR complex protein DEPDC5 isoform X2

      Conserved Domains (2) summary
      cd04449
      Location:11671248
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:101381
      IML1; Vacuolar membrane-associated protein Iml1
    9. XM_030254554.2XP_030110414.1  GATOR complex protein DEPDC5 isoform X8

      Conserved Domains (2) summary
      cd04449
      Location:10071088
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:1212
      IML1; Vacuolar membrane-associated protein Iml1
    10. XM_006503978.4XP_006504041.1  GATOR complex protein DEPDC5 isoform X1

      See identical proteins and their annotated locations for XP_006504041.1

      Conserved Domains (2) summary
      cd04449
      Location:11761257
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:101381
      IML1; Vacuolar membrane-associated protein Iml1
    11. XM_006503985.4XP_006504048.1  GATOR complex protein DEPDC5 isoform X3

      Conserved Domains (2) summary
      cd04449
      Location:11541235
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:101381
      IML1; Vacuolar membrane-associated protein Iml1
    12. XM_006503984.4XP_006504047.1  GATOR complex protein DEPDC5 isoform X2

      See identical proteins and their annotated locations for XP_006504047.1

      UniProtKB/Swiss-Prot
      P61460
      Conserved Domains (2) summary
      cd04449
      Location:11671248
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:101381
      IML1; Vacuolar membrane-associated protein Iml1
    13. XM_006503987.4XP_006504050.1  GATOR complex protein DEPDC5 isoform X5

      UniProtKB/Swiss-Prot
      P61460
      Related
      ENSMUSP00000113980.2, ENSMUST00000120902.8
      Conserved Domains (2) summary
      cd04449
      Location:11451226
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:101381
      IML1; Vacuolar membrane-associated protein Iml1
    14. XM_006503986.4XP_006504049.1  GATOR complex protein DEPDC5 isoform X4

      Conserved Domains (2) summary
      cd04449
      Location:11541235
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:101381
      IML1; Vacuolar membrane-associated protein Iml1
    15. XM_030254552.2XP_030110412.1  GATOR complex protein DEPDC5 isoform X8

      Conserved Domains (2) summary
      cd04449
      Location:10071088
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:1212
      IML1; Vacuolar membrane-associated protein Iml1
    16. XM_006503979.4XP_006504042.1  GATOR complex protein DEPDC5 isoform X1

      See identical proteins and their annotated locations for XP_006504042.1

      Conserved Domains (2) summary
      cd04449
      Location:11761257
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:101381
      IML1; Vacuolar membrane-associated protein Iml1
    17. XM_006503982.4XP_006504045.1  GATOR complex protein DEPDC5 isoform X1

      See identical proteins and their annotated locations for XP_006504045.1

      Conserved Domains (2) summary
      cd04449
      Location:11761257
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:101381
      IML1; Vacuolar membrane-associated protein Iml1
    18. XM_036165162.1XP_036021055.1  GATOR complex protein DEPDC5 isoform X6

      Conserved Domains (2) summary
      cd04449
      Location:11761257
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:101381
      IML1; Vacuolar membrane-associated protein Iml1
    19. XM_036165163.1XP_036021056.1  GATOR complex protein DEPDC5 isoform X7

      Conserved Domains (2) summary
      cd04449
      Location:11671248
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:101381
      IML1; Vacuolar membrane-associated protein Iml1
    20. XM_006503988.4XP_006504051.1  GATOR complex protein DEPDC5 isoform X8

      Conserved Domains (2) summary
      cd04449
      Location:10071088
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:1212
      IML1; Vacuolar membrane-associated protein Iml1
    21. XM_030254555.2XP_030110415.1  GATOR complex protein DEPDC5 isoform X8

      Conserved Domains (2) summary
      cd04449
      Location:10071088
      DEP_DEPDC5-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.
      pfam12257
      Location:1212
      IML1; Vacuolar membrane-associated protein Iml1
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