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    Eif5a eukaryotic translation initiation factor 5A [ Mus musculus (house mouse) ]

    Gene ID: 276770, updated on 22-Aug-2021

    Summary

    Official Symbol
    Eif5aprovided by MGI
    Official Full Name
    eukaryotic translation initiation factor 5Aprovided by MGI
    Primary source
    MGI:MGI:106248
    See related
    Ensembl:ENSMUSG00000078812
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Eif4d; Eif5a1; eIF-4D; eIF-5A; eIF-5A1; AA410058; D19Wsu54; eIF-5A-1; D19Wsu54e
    Summary
    This gene encodes an elongation initiation factor, which participates in protein synthesis. The encoded protein also plays roles in mRNA metabolism, cell proliferation, and cell cycle control. This protein contains a modified lysine residue called hypusine, which appears to be necessary for its function. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 2, 5, and 19. [provided by RefSeq, Oct 2009]
    Expression
    Ubiquitous expression in liver E14 (RPKM 325.9), liver E14.5 (RPKM 312.4) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Eif5a in Genome Data Viewer
    Location:
    11; 11 B3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (69807538..69812784, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (69916712..69921958, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (69730214..69735460, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2810408A11 gene Neighboring gene neuralized E3 ubiquitin protein ligase 4 Neighboring gene G protein pathway suppressor 2 Neighboring gene Y box protein 2 Neighboring gene solute carrier family 2 (facilitated glucose transporter), member 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC6725

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables U6 snRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein N-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ribosome binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables translation elongation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in annulate lamellae ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nuclear pore ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    eukaryotic translation initiation factor 5A-1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166589.1NP_001160061.1  eukaryotic translation initiation factor 5A-1

      See identical proteins and their annotated locations for NP_001160061.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, also referred to as variant BD) represents the longest transcript. Variants 1-9 encode the same protein.
      Source sequence(s)
      AI850684, AK010183, AK011306, AK218644, AL596185, CX237346
      Consensus CDS
      CCDS24923.1
      UniProtKB/Swiss-Prot
      P63242
      Related
      ENSMUSP00000047008.4, ENSMUST00000043419.10
      Conserved Domains (1) summary
      cl30809
      Location:1150
      PLN03107; eukaryotic translation initiation factor 5A; Provisional
    2. NM_001166590.1NP_001160062.1  eukaryotic translation initiation factor 5A-1

      See identical proteins and their annotated locations for NP_001160062.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, also referred to as variant D) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
      Source sequence(s)
      AI850684, AK011306, AK218644, AL596185, CX237346
      Consensus CDS
      CCDS24923.1
      UniProtKB/Swiss-Prot
      P63242
      Related
      ENSMUSP00000104250.2, ENSMUST00000108610.8
      Conserved Domains (1) summary
      cl30809
      Location:1150
      PLN03107; eukaryotic translation initiation factor 5A; Provisional
    3. NM_001166591.1NP_001160063.1  eukaryotic translation initiation factor 5A-1

      See identical proteins and their annotated locations for NP_001160063.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3, also referred to as variant BE) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
      Source sequence(s)
      AI850684, AK010183, AK011306, AK218644, AL596185
      Consensus CDS
      CCDS24923.1
      UniProtKB/Swiss-Prot
      P63242
      Related
      ENSMUSP00000067077.5, ENSMUST00000070996.11
      Conserved Domains (1) summary
      cl30809
      Location:1150
      PLN03107; eukaryotic translation initiation factor 5A; Provisional
    4. NM_001166592.1NP_001160064.1  eukaryotic translation initiation factor 5A-1

      See identical proteins and their annotated locations for NP_001160064.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4, also referred to as variant CD) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
      Source sequence(s)
      AI850684, AK011306, AK218644, CX218195, CX237346
      Consensus CDS
      CCDS24923.1
      UniProtKB/Swiss-Prot
      P63242
      Related
      ENSMUSP00000104251.2, ENSMUST00000108611.8
      Conserved Domains (1) summary
      cl30809
      Location:1150
      PLN03107; eukaryotic translation initiation factor 5A; Provisional
    5. NM_001166593.1NP_001160065.1  eukaryotic translation initiation factor 5A-1

      See identical proteins and their annotated locations for NP_001160065.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6, also referred to as variant AE) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
      Source sequence(s)
      AI850684, AK011306, AK218644, AL596185
      Consensus CDS
      CCDS24923.1
      UniProtKB/Swiss-Prot
      P63242
      Related
      ENSMUSP00000068651.4, ENSMUST00000071026.10
      Conserved Domains (1) summary
      cl30809
      Location:1150
      PLN03107; eukaryotic translation initiation factor 5A; Provisional
    6. NM_001166594.1NP_001160066.1  eukaryotic translation initiation factor 5A-1

      See identical proteins and their annotated locations for NP_001160066.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7, also referred to as variant C) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
      Source sequence(s)
      AI850684, AK011306, AK218644, CX218195, CX237346
      Consensus CDS
      CCDS24923.1
      UniProtKB/Swiss-Prot
      P63242
      Related
      ENSMUSP00000104252.2, ENSMUST00000108612.8
      Conserved Domains (1) summary
      cl30809
      Location:1150
      PLN03107; eukaryotic translation initiation factor 5A; Provisional
    7. NM_001166595.1NP_001160067.1  eukaryotic translation initiation factor 5A-1

      See identical proteins and their annotated locations for NP_001160067.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
      Source sequence(s)
      AI850684, AK011306, AK218644, AL596185
      Consensus CDS
      CCDS24923.1
      UniProtKB/Swiss-Prot
      P63242
      Conserved Domains (1) summary
      cl30809
      Location:1150
      PLN03107; eukaryotic translation initiation factor 5A; Provisional
    8. NM_001166596.1NP_001160068.1  eukaryotic translation initiation factor 5A-1

      See identical proteins and their annotated locations for NP_001160068.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
      Source sequence(s)
      AI850684, AK011306, AK218644, AL596185, CX237346
      Consensus CDS
      CCDS24923.1
      UniProtKB/Swiss-Prot
      P63242
      Related
      ENSMUSP00000132717.2, ENSMUST00000164359.8
      Conserved Domains (1) summary
      cl30809
      Location:1150
      PLN03107; eukaryotic translation initiation factor 5A; Provisional
    9. NM_181582.4NP_853613.1  eukaryotic translation initiation factor 5A-1

      See identical proteins and their annotated locations for NP_853613.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5, also referred to as variant B) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
      Source sequence(s)
      AI850684, AK010183, AK011306, AK218644, AL596185
      Consensus CDS
      CCDS24923.1
      UniProtKB/Swiss-Prot
      P63242
      Related
      ENSMUSP00000104253.4, ENSMUST00000108613.10
      Conserved Domains (1) summary
      cl30809
      Location:1150
      PLN03107; eukaryotic translation initiation factor 5A; Provisional

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      69807538..69812784 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246050.2XP_030101910.1  eukaryotic translation initiation factor 5A-1 isoform X1

      Conserved Domains (1) summary
      cl30809
      Location:1150
      PLN03107; eukaryotic translation initiation factor 5A; Provisional
    2. XM_011249058.4XP_011247360.1  eukaryotic translation initiation factor 5A-1 isoform X1

      See identical proteins and their annotated locations for XP_011247360.1

      UniProtKB/Swiss-Prot
      P63242
      Related
      ENSMUSP00000104249.2, ENSMUST00000108609.8
      Conserved Domains (1) summary
      cl30809
      Location:1150
      PLN03107; eukaryotic translation initiation factor 5A; Provisional
    3. XM_030246051.1XP_030101911.1  eukaryotic translation initiation factor 5A-1 isoform X1

      Conserved Domains (1) summary
      cl30809
      Location:1150
      PLN03107; eukaryotic translation initiation factor 5A; Provisional
    4. XM_036156739.1XP_036012632.1  eukaryotic translation initiation factor 5A-1 isoform X1

      Conserved Domains (1) summary
      cl30809
      Location:1150
      PLN03107; eukaryotic translation initiation factor 5A; Provisional
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