Format

Send to:

Choose Destination
    • Showing Current items.

    Eif5a eukaryotic translation initiation factor 5A [ Mus musculus (house mouse) ]

    Gene ID: 276770, updated on 31-Jan-2019

    Summary

    Official Symbol
    Eif5aprovided by MGI
    Official Full Name
    eukaryotic translation initiation factor 5Aprovided by MGI
    Primary source
    MGI:MGI:106248
    See related
    Ensembl:ENSMUSG00000078812
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Eif4d; Eif5a1; eIF-4D; eIF-5A; eIF-5A1; AA410058; eIF-5A-1; D19Wsu54e
    Summary
    This gene encodes an elongation initiation factor, which participates in protein synthesis. The encoded protein also plays roles in mRNA metabolism, cell proliferation, and cell cycle control. This protein contains a modified lysine residue called hypusine, which appears to be necessary for its function. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 2, 5, and 19. [provided by RefSeq, Oct 2009]
    Expression
    Ubiquitous expression in liver E14 (RPKM 325.9), liver E14.5 (RPKM 312.4) and 28 other tissues See more
    Orthologs

    Genomic context

    See Eif5a in Genome Data Viewer
    Location:
    11; 11 B3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (69916712..69921958, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (69730214..69735460, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2810408A11 gene Neighboring gene neuralized E3 ubiquitin protein ligase 4 Neighboring gene G protein pathway suppressor 2 Neighboring gene Y box protein 2 Neighboring gene solute carrier family 2 (facilitated glucose transporter), member 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC6725

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    U6 snRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein N-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    ribosome binding IEA
    Inferred from Electronic Annotation
    more info
     
    translation elongation factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA transport IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cardiac muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of translational elongation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of translational termination IEA
    Inferred from Electronic Annotation
    more info
     
    protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    translation IEA
    Inferred from Electronic Annotation
    more info
     
    translational elongation IEA
    Inferred from Electronic Annotation
    more info
     
    translational frameshifting IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    annulate lamellae ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear pore ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    eukaryotic translation initiation factor 5A-1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166589.1NP_001160061.1  eukaryotic translation initiation factor 5A-1

      See identical proteins and their annotated locations for NP_001160061.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, also referred to as variant BD) represents the longest transcript. Variants 1-9 encode the same protein.
      Source sequence(s)
      AI850684, AK010183, AK011306, AK218644, AL596185, CX237346
      Consensus CDS
      CCDS24923.1
      UniProtKB/Swiss-Prot
      P63242
      Related
      ENSMUSP00000047008.3, ENSMUST00000043419.9
      Conserved Domains (1) summary
      cl28432
      Location:1150
      PRK03999; translation initiation factor IF-5A; Provisional
    2. NM_001166590.1NP_001160062.1  eukaryotic translation initiation factor 5A-1

      See identical proteins and their annotated locations for NP_001160062.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, also referred to as variant D) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
      Source sequence(s)
      AI850684, AK011306, AK218644, AL596185, CX237346
      Consensus CDS
      CCDS24923.1
      UniProtKB/Swiss-Prot
      P63242
      Related
      ENSMUSP00000104250.1, ENSMUST00000108610.7
      Conserved Domains (1) summary
      cl28432
      Location:1150
      PRK03999; translation initiation factor IF-5A; Provisional
    3. NM_001166591.1NP_001160063.1  eukaryotic translation initiation factor 5A-1

      See identical proteins and their annotated locations for NP_001160063.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3, also referred to as variant BE) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
      Source sequence(s)
      AI850684, AK010183, AK011306, AK218644, AL596185
      Consensus CDS
      CCDS24923.1
      UniProtKB/Swiss-Prot
      P63242
      Related
      ENSMUSP00000067077.4, ENSMUST00000070996.10
      Conserved Domains (1) summary
      cl28432
      Location:1150
      PRK03999; translation initiation factor IF-5A; Provisional
    4. NM_001166592.1NP_001160064.1  eukaryotic translation initiation factor 5A-1

      See identical proteins and their annotated locations for NP_001160064.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4, also referred to as variant CD) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
      Source sequence(s)
      AI850684, AK011306, AK218644, CX218195, CX237346
      Consensus CDS
      CCDS24923.1
      UniProtKB/Swiss-Prot
      P63242
      Related
      ENSMUSP00000104251.1, ENSMUST00000108611.7
      Conserved Domains (1) summary
      cl28432
      Location:1150
      PRK03999; translation initiation factor IF-5A; Provisional
    5. NM_001166593.1NP_001160065.1  eukaryotic translation initiation factor 5A-1

      See identical proteins and their annotated locations for NP_001160065.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6, also referred to as variant AE) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
      Source sequence(s)
      AI850684, AK011306, AK218644, AL596185
      Consensus CDS
      CCDS24923.1
      UniProtKB/Swiss-Prot
      P63242
      Related
      ENSMUSP00000068651.3, ENSMUST00000071026.9
      Conserved Domains (1) summary
      cl28432
      Location:1150
      PRK03999; translation initiation factor IF-5A; Provisional
    6. NM_001166594.1NP_001160066.1  eukaryotic translation initiation factor 5A-1

      See identical proteins and their annotated locations for NP_001160066.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7, also referred to as variant C) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
      Source sequence(s)
      AI850684, AK011306, AK218644, CX218195, CX237346
      Consensus CDS
      CCDS24923.1
      UniProtKB/Swiss-Prot
      P63242
      Related
      ENSMUSP00000104252.1, ENSMUST00000108612.7
      Conserved Domains (1) summary
      cl28432
      Location:1150
      PRK03999; translation initiation factor IF-5A; Provisional
    7. NM_001166595.1NP_001160067.1  eukaryotic translation initiation factor 5A-1

      See identical proteins and their annotated locations for NP_001160067.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
      Source sequence(s)
      AI850684, AK011306, AK218644, AL596185
      Consensus CDS
      CCDS24923.1
      UniProtKB/Swiss-Prot
      P63242
      Conserved Domains (1) summary
      cl28432
      Location:1150
      PRK03999; translation initiation factor IF-5A; Provisional
    8. NM_001166596.1NP_001160068.1  eukaryotic translation initiation factor 5A-1

      See identical proteins and their annotated locations for NP_001160068.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
      Source sequence(s)
      AI850684, AK011306, AK218644, AL596185, CX237346
      Consensus CDS
      CCDS24923.1
      UniProtKB/Swiss-Prot
      P63242
      Related
      ENSMUSP00000132717.1, ENSMUST00000164359.7
      Conserved Domains (1) summary
      cl28432
      Location:1150
      PRK03999; translation initiation factor IF-5A; Provisional
    9. NM_181582.4NP_853613.1  eukaryotic translation initiation factor 5A-1

      See identical proteins and their annotated locations for NP_853613.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5, also referred to as variant B) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
      Source sequence(s)
      AI850684, AK010183, AK011306, AK218644, AL596185
      Consensus CDS
      CCDS24923.1
      UniProtKB/Swiss-Prot
      P63242
      Related
      ENSMUSP00000104253.3, ENSMUST00000108613.9
      Conserved Domains (1) summary
      cl28432
      Location:1150
      PRK03999; translation initiation factor IF-5A; Provisional

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      69916712..69921958 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011249058.2XP_011247360.1  eukaryotic translation initiation factor 5A-1 isoform X1

      See identical proteins and their annotated locations for XP_011247360.1

      UniProtKB/Swiss-Prot
      P63242
      Related
      ENSMUSP00000104249.1, ENSMUST00000108609.7
      Conserved Domains (1) summary
      cl28432
      Location:1150
      PRK03999; translation initiation factor IF-5A; Provisional

    Reference GRCm38.p4 NOD/MrkTac

    Genomic

    1. NT_187026.1 Reference GRCm38.p4 NOD/MrkTac

      Range
      21240..26486 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center