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    AMY1A amylase alpha 1A [ Homo sapiens (human) ]

    Gene ID: 276, updated on 17-Jun-2024

    Summary

    Official Symbol
    AMY1Aprovided by HGNC
    Official Full Name
    amylase alpha 1Aprovided by HGNC
    Primary source
    HGNC:HGNC:474
    See related
    Ensembl:ENSG00000237763 MIM:104700; AllianceGenome:HGNC:474
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AMY1
    Summary
    Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the salivary gland. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward salivary gland (RPKM 4834.2) See more
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    Genomic context

    See AMY1A in Genome Data Viewer
    Location:
    1p21.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (103655519..103664554)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (103504385..103513421)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (104198141..104207176)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene amylase alpha 2B Neighboring gene actin gamma 1 pseudogene 4 Neighboring gene amylase alpha 2A Neighboring gene uncharacterized LOC124904594 Neighboring gene amylase alpha 1B

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    alpha-amylase 1A
    Names
    1,4-alpha-D-glucan glucanohydrolase 1
    alpha-amylase 1
    amylase alpha 1A (salivary)
    amylase, salivary, alpha-1A
    glycogenase
    salivary alpha-amylase
    salivary amylase alpha 1A
    NP_001008222.1
    NP_004029.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008221.1NP_001008222.1  alpha-amylase 1A precursor

      See identical proteins and their annotated locations for NP_001008222.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC063129, BC070302, BX487266
      Consensus CDS
      CCDS30782.1
      UniProtKB/Swiss-Prot
      A6NJS5, A8K8H6, P04745, P0DTE7, P0DTE8, P0DUB6, Q13763, Q5T083
      UniProtKB/TrEMBL
      B7ZMD7
      Conserved Domains (2) summary
      cd11317
      Location:25416
      AmyAc_bac_euk_AmyA; Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase)
      smart00632
      Location:422510
      Aamy_C; Aamy_C domain
    2. NM_004038.4NP_004029.2  alpha-amylase 1A precursor

      See identical proteins and their annotated locations for NP_004029.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC105272
      Consensus CDS
      CCDS30782.1
      UniProtKB/Swiss-Prot
      A6NJS5, A8K8H6, P04745, P0DTE7, P0DTE8, P0DUB6, Q13763, Q5T083
      UniProtKB/TrEMBL
      B7ZMD7
      Related
      ENSP00000359100.4, ENST00000370083.9
      Conserved Domains (2) summary
      cd11317
      Location:25416
      AmyAc_bac_euk_AmyA; Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase)
      smart00632
      Location:422510
      Aamy_C; Aamy_C domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      103655519..103664554
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      103504385..103513421
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)