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    Abcf2 ATP-binding cassette, sub-family F (GCN20), member 2 [ Mus musculus (house mouse) ]

    Gene ID: 27407, updated on 26-Sep-2022

    Summary

    Official Symbol
    Abcf2provided by MGI
    Official Full Name
    ATP-binding cassette, sub-family F (GCN20), member 2provided by MGI
    Primary source
    MGI:MGI:1351657
    See related
    Ensembl:ENSMUSG00000028953 AllianceGenome:MGI:1351657
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Drr3; E430001O06; 0710005O05Rik
    Summary
    Predicted to enable ATP binding activity. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human ABCF2 (ATP binding cassette subfamily F member 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 70.0), thymus adult (RPKM 32.4) and 28 other tissues See more
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    Genomic context

    See Abcf2 in Genome Data Viewer
    Location:
    5; 5 A3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (24770339..24782465, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (24565341..24577467, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and SOCS box-containing 10 Neighboring gene IQ motif containing with AAA domain 1 like Neighboring gene ATP synthase, H+ transporting, mitochondrial F0 complex, subunit g pseudogene Neighboring gene chondroitin polymerizing factor 2 Neighboring gene microRNA 671

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    • Homologs of the Abcf2 gene: The Abcf2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, M.oryzae, N.crassa, A.thaliana, and rice.
    • Orthologs

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 

    General protein information

    Preferred Names
    ATP-binding cassette sub-family F member 2
    Names
    developmentally regulated repeat element-containing transcript 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190443.1NP_001177372.1  ATP-binding cassette sub-family F member 2 isoform 2

      See identical proteins and their annotated locations for NP_001177372.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region compared to variant 3. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
      Source sequence(s)
      AK147937, AK151545, BY731788, BY790180
      UniProtKB/Swiss-Prot
      Q99LE6
      Conserved Domains (3) summary
      cd03221
      Location:90306
      ABCF_EF-3; ATP-binding cassette domain of elongation factor 3, subfamily F
      COG0488
      Location:87607
      Uup; ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]
      pfam12848
      Location:300370
      ABC_tran_Xtn; ABC transporter
    2. NM_001359205.1NP_001346134.1  ATP-binding cassette sub-family F member 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 3 both encode the same isoform (1).
      Source sequence(s)
      AC116136
      Consensus CDS
      CCDS19125.1
      UniProtKB/Swiss-Prot
      Q9JL48
      Conserved Domains (1) summary
      COG0488
      Location:88608
      Uup; ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]
    3. NM_013853.2NP_038881.1  ATP-binding cassette sub-family F member 2 isoform 1

      See identical proteins and their annotated locations for NP_038881.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1 and 3 both encode the same isoform (1).
      Source sequence(s)
      AK147937, AK151545, BY731788
      Consensus CDS
      CCDS19125.1
      UniProtKB/Swiss-Prot
      Q99LE6, Q9JL48
      Related
      ENSMUSP00000030795.9, ENSMUST00000030795.10
      Conserved Domains (1) summary
      COG0488
      Location:88608
      Uup; ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      24770339..24782465 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006535727.4XP_006535790.1  ATP-binding cassette sub-family F member 2 isoform X1

      See identical proteins and their annotated locations for XP_006535790.1

      UniProtKB/Swiss-Prot
      Q99LE6, Q9JL48
      Conserved Domains (1) summary
      COG0488
      Location:88608
      Uup; ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]