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    Skp2 S-phase kinase-associated protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 27401, updated on 6-Sep-2021

    Summary

    Official Symbol
    Skp2provided by MGI
    Official Full Name
    S-phase kinase-associated protein 2provided by MGI
    Primary source
    MGI:MGI:1351663
    See related
    Ensembl:ENSMUSG00000054115
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p45; FBXL; FWD1; FBXL1; 4930500A04Rik
    Expression
    Biased expression in testis adult (RPKM 26.1), limb E14.5 (RPKM 12.8) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Skp2 in Genome Data Viewer
    Location:
    15; 15 A1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (9112070..9155512, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (9111982..9155425, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (9041742..9070207, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene RAN binding protein 3-like Neighboring gene predicted gene, 53883 Neighboring gene NAD kinase 2, mitochondrial Neighboring gene LMBR1 domain containing 2 Neighboring gene UDP glycosyltransferases 3 family pseudogene Neighboring gene UDP glycosyltransferases 3 family, polypeptide A1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC102075, MGC116668, 4930500A04Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within G1/S transition of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in G2/M transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within G2/M transition of mitotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within G2/M transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in defense response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of intracellular estrogen receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in regulation of cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within regulation of cell cycle IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of SCF ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of SCF ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    S-phase kinase-associated protein 2
    Names
    F-box protein Skp2
    F-box/WD-40 protein 1
    cyclin A/CDK2-associated protein p45

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285980.1NP_001272909.1  S-phase kinase-associated protein 2 isoform c

      See identical proteins and their annotated locations for NP_001272909.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks part of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AC139209, AK006221, AK015652, BC092236
      Consensus CDS
      CCDS79360.1
      UniProtKB/TrEMBL
      A0A087WQ11, Q569Z9
      Related
      ENSMUSP00000139997.2, ENSMUST00000190131.2
      Conserved Domains (3) summary
      cd09293
      Location:158310
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:102132
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:62107
      F-box-like; F-box-like
    2. NM_013787.3NP_038815.1  S-phase kinase-associated protein 2 isoform a

      See identical proteins and their annotated locations for NP_038815.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC139209, AK166034, BY740905
      Consensus CDS
      CCDS37037.1
      UniProtKB/Swiss-Prot
      Q9Z0Z3
      UniProtKB/TrEMBL
      Q569Z9
      Related
      ENSMUSP00000094225.4, ENSMUST00000096482.10
      Conserved Domains (3) summary
      cd09293
      Location:193345
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:137167
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:97142
      F-box-like; F-box-like

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      9112070..9155512 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245359.3XP_011243661.1  S-phase kinase-associated protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011243661.1

      Conserved Domains (3) summary
      cd09293
      Location:203355
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:147177
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:107151
      F-box-like

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_145468.1: Suppressed sequence

      Description
      NM_145468.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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