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    Prmt5 protein arginine N-methyltransferase 5 [ Mus musculus (house mouse) ]

    Gene ID: 27374, updated on 6-Sep-2021

    Summary

    Official Symbol
    Prmt5provided by MGI
    Official Full Name
    protein arginine N-methyltransferase 5provided by MGI
    Primary source
    MGI:MGI:1351645
    See related
    Ensembl:ENSMUSG00000023110
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Jbp; Skb; Jbp1; Skb1
    Summary
    This gene encodes an enzyme that belongs to the methyltransferase family. The encoded protein catalyzes the transfer of methyl groups to the amino acid arginine, in target proteins that include histones, transcriptional elongation factors and the tumor suppressor p53. This gene plays a role in several cellular processes, including transcriptional regulation and the assembly of small nuclear ribonucleoproteins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 31.6), CNS E14 (RPKM 26.3) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Prmt5 in Genome Data Viewer
    Location:
    14; 14 C2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (54744639..54754927, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (54507182..54517470, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (55126019..55136307, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene rad and gem related GTP binding protein 2 Neighboring gene predicted gene, 41153 Neighboring gene nuclear encoded tRNA arginine 6 (anticodon ACG) Neighboring gene predicted gene, 53858

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables E-box binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chromatin binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables histone methyltransferase activity (H4-R3 specific) ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone-arginine N-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables methyl-CpG binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables p53 binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables protein-arginine N-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-arginine omega-N symmetric methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ribonucleoprotein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription corepressor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in DNA-templated transcription, termination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in Golgi ribbon formation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in circadian regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in endothelial cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histone H4-R3 methylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in histone arginine methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within peptidyl-arginine N-methylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in peptidyl-arginine N-methylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-arginine methylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of oligodendrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein methylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of DNA methylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription, DNA-templated IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in spliceosomal snRNP assembly ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of histone methyltransferase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of histone methyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of methylosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein arginine N-methyltransferase 5
    Names
    Jak-binding protein 1
    SKB1 homolog
    histone-arginine N-methyltransferase PRMT5
    shk1 kinase-binding protein 1 homolog
    NP_001300835.1
    NP_001300836.1
    NP_038796.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313906.1NP_001300835.1  protein arginine N-methyltransferase 5 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' terminal exon, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK076346, AK084106, AK165165, CF726158
      UniProtKB/Swiss-Prot
      Q8CIG8
      Conserved Domains (2) summary
      pfam05185
      Location:164600
      PRMT5; PRMT5 arginine-N-methyltransferase
      pfam16950
      Location:165446
      SAMBD; SAM-binding_domain
    2. NM_001313907.1NP_001300836.1  protein arginine N-methyltransferase 5 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK076346, AK084106, AK165165, BY101080
      UniProtKB/Swiss-Prot
      Q8CIG8
      Conserved Domains (2) summary
      pfam05185
      Location:77513
      PRMT5; PRMT5 arginine-N-methyltransferase
      pfam16950
      Location:78359
      SAMBD; SAM-binding_domain
    3. NM_013768.3NP_038796.2  protein arginine N-methyltransferase 5 isoform 1

      See identical proteins and their annotated locations for NP_038796.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK076346, AK165165, BY064945
      Consensus CDS
      CCDS27091.1
      UniProtKB/Swiss-Prot
      Q8CIG8
      UniProtKB/TrEMBL
      A0A0R4J049
      Related
      ENSMUSP00000023873.6, ENSMUST00000023873.12
      Conserved Domains (2) summary
      pfam05185
      Location:183619
      PRMT5; PRMT5 arginine-N-methyltransferase
      pfam16950
      Location:184465
      SAMBD; SAM-binding_domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      54744639..54754927 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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