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    Txnl4a thioredoxin-like 4A [ Mus musculus (house mouse) ]

    Gene ID: 27366, updated on 23-Jun-2021

    Summary

    Official Symbol
    Txnl4aprovided by MGI
    Official Full Name
    thioredoxin-like 4Aprovided by MGI
    Primary source
    MGI:MGI:1351613
    See related
    Ensembl:ENSMUSG00000057130
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dim1; Txnl4; U5-15kD; U5-15kDa; D18Wsu98e
    Expression
    Ubiquitous expression in ovary adult (RPKM 29.5), CNS E11.5 (RPKM 21.3) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Txnl4a in Genome Data Viewer
    Location:
    18 E3; 18 53.34 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (80250041..80269066)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (80206826..80225851)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (80403537..80422590)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene ribosome binding factor A, opposite strand Neighboring gene predicted gene, 46629 Neighboring gene ribosome binding factor A Neighboring gene predicted gene 16286 Neighboring gene heat shock factor binding protein 1-like 1 Neighboring gene solute carrier family 66 member 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of U2-type precatalytic spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of U4/U6 x U5 tri-snRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of U4/U6 x U5 tri-snRNP complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of U5 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of U5 snRNP ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    part_of U5 snRNP TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    thioredoxin-like protein 4A
    Names
    DIM1 protein homolog
    spliceosomal U5 snRNP-specific 15 kDa protein
    thioredoxin-like 4
    thioredoxin-like U5 snRNP protein U5-15kD

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001038608.3NP_001033697.2  thioredoxin-like protein 4A isoform b

      See identical proteins and their annotated locations for NP_001033697.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' coding exons and 3' UTR compared to variant 1. The resulting isoform (b) is shorter and has a unique C-terminus compared to isoform a. Variants 2-4 all encode the same isoform (b).
      Source sequence(s)
      AC131065
      UniProtKB/TrEMBL
      Q78JM7, Q9CQX6
      Conserved Domains (1) summary
      cl00388
      Location:151
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    2. NM_001042408.2NP_001035867.1  thioredoxin-like protein 4A isoform b

      See identical proteins and their annotated locations for NP_001035867.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, 3' coding exons, and 3' UTR, compared to variant 1. The resulting isoform (b) is shorter and has a unique C-terminus compared to isoform a. Variants 2-4 all encode the same isoform (b).
      Source sequence(s)
      AC131065
      UniProtKB/TrEMBL
      Q78JM7, Q9CQX6
      Conserved Domains (1) summary
      cl00388
      Location:151
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    3. NM_001384173.1NP_001371102.1  thioredoxin-like protein 4A isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5), as well as variants 1 and 6, encodes isoform a.
      Source sequence(s)
      AC131065
      Conserved Domains (1) summary
      PLN00410
      Location:1142
      PLN00410; U5 snRNP protein, DIM1 family; Provisional
    4. NM_001384174.1NP_001371103.1  thioredoxin-like protein 4A isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6), as well as variants 1 and 5, encodes isoform a.
      Source sequence(s)
      AC131065
      Conserved Domains (1) summary
      PLN00410
      Location:1142
      PLN00410; U5 snRNP protein, DIM1 family; Provisional
    5. NM_001384175.1NP_001371104.1  thioredoxin-like protein 4A isoform c

      Status: VALIDATED

      Source sequence(s)
      AC131065
      Conserved Domains (1) summary
      cl00388
      Location:151
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    6. NM_001384176.1NP_001371105.1  thioredoxin-like protein 4A isoform d

      Status: VALIDATED

      Source sequence(s)
      AC131065
      Conserved Domains (1) summary
      cl00388
      Location:151
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    7. NM_001384177.1NP_001371106.1  thioredoxin-like protein 4A isoform e

      Status: VALIDATED

      Source sequence(s)
      AC131065
      Conserved Domains (1) summary
      cl00388
      Location:151
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    8. NM_025299.4NP_079575.1  thioredoxin-like protein 4A isoform a

      See identical proteins and their annotated locations for NP_079575.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1, 5, and 6 all encode the same isoform (a).
      Source sequence(s)
      AC131065
      Consensus CDS
      CCDS29365.1
      UniProtKB/Swiss-Prot
      P83877
      Related
      ENSMUSP00000115320.2, ENSMUST00000145963.9
      Conserved Domains (1) summary
      PLN00410
      Location:1142
      PLN00410; U5 snRNP protein, DIM1 family; Provisional
    9. NM_178604.4NP_848719.2  thioredoxin-like protein 4A isoform b

      See identical proteins and their annotated locations for NP_848719.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, 3' coding exons, and 3' UTR, compared to variant 1. The resulting isoform (b) is shorter and has a unique C-terminus compared to isoform a. Variants 2-4 all encode the same isoform (b).
      Source sequence(s)
      AC131065
      UniProtKB/TrEMBL
      Q78JM7, Q9CQX6
      Conserved Domains (1) summary
      cl00388
      Location:151
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    RNA

    1. NR_168913.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC131065
    2. NR_168914.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC131065
    3. NR_168915.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC131065

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      80250041..80269066
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001042409.1: Suppressed sequence

      Description
      NM_001042409.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
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