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    DIMT1 DIM1 rRNA methyltransferase and ribosome maturation factor [ Homo sapiens (human) ]

    Gene ID: 27292, updated on 11-Apr-2024

    Summary

    Official Symbol
    DIMT1provided by HGNC
    Official Full Name
    DIM1 rRNA methyltransferase and ribosome maturation factorprovided by HGNC
    Primary source
    HGNC:HGNC:30217
    See related
    Ensembl:ENSG00000086189 MIM:612499; AllianceGenome:HGNC:30217
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DIM1; DIMT1L; HUSSY5; HSA9761
    Summary
    The protein encoded by this gene is a methyltransferase that is responsible for dimethylation of adjacent adenosines near the 18S rRNA decoding site. The encoded protein is essential for ribosome biogenesis, although its catalytic activity is not involved in the process. The yeast ortholog of this protein functions in the cytoplasm while this protein functions in the nucleus. [provided by RefSeq, Jan 2017]
    Expression
    Ubiquitous expression in urinary bladder (RPKM 12.5), lymph node (RPKM 11.7) and 25 other tissues See more
    Orthologs
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    Genomic context

    Location:
    5q12.1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (62387254..62403905, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (63206803..63223500, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (61683081..61699732, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:61457226-61457726 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:61457727-61458227 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:61458278-61458778 Neighboring gene RN7SK pseudogene 157 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16050 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:61532143-61532644 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:61532645-61533144 Neighboring gene CRISPRi-validated cis-regulatory element chr5.1488 Neighboring gene Sharpr-MPRA regulatory region 4645 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22594 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22595 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16051 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:61610189-61610690 Neighboring gene CREB regulated transcription coactivator 2 pseudogene Neighboring gene kinesin family member 2A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22596 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22597 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16052 Neighboring gene importin 11 Neighboring gene RNA, U6 small nuclear 661, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr5:61791875-61792070 Neighboring gene CDC28 protein kinase regulatory subunit 1B pseudogene 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of DIM1 dimethyladenosine transferase 1 homolog (DIMT1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in positive regulation of rRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in rRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in rRNA methylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in rRNA methylation TAS
    Traceable Author Statement
    more info
     
    involved_in ribosomal small subunit biogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    part_of small-subunit processome IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    probable dimethyladenosine transferase
    Names
    18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase
    18S rRNA dimethylase
    DIM1 dimethyladenosine transferase 1 homolog
    DIM1 dimethyladenosine transferase 1-like
    DIMT1 rRNA methyltransferase and ribosome maturation factor
    S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase
    dimethyladenosine transferase
    probable 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase
    probable 18S rRNA dimethylase
    probable S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase
    NP_001335005.1
    NP_001335006.1
    NP_055288.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001348076.2NP_001335005.1  probable dimethyladenosine transferase isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC016637, BC002841, DC398380
      Consensus CDS
      CCDS87298.1
      UniProtKB/TrEMBL
      A0A0C4DGB1, B4DRY2
      Related
      ENSP00000421754.1, ENST00000506390.5
      Conserved Domains (1) summary
      cl17173
      Location:24263
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    2. NM_001348077.2NP_001335006.1  probable dimethyladenosine transferase isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice junction compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC016637
      Conserved Domains (1) summary
      cl17173
      Location:1159
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    3. NM_014473.4NP_055288.1  probable dimethyladenosine transferase isoform 1

      See identical proteins and their annotated locations for NP_055288.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC016637, AK292723, BQ009563
      Consensus CDS
      CCDS3981.1
      UniProtKB/Swiss-Prot
      O76025, Q9BU77, Q9UES1, Q9UNQ2
      UniProtKB/TrEMBL
      A8K9K8
      Related
      ENSP00000199320.4, ENST00000199320.9
      Conserved Domains (1) summary
      PTZ00338
      Location:24312
      PTZ00338; dimethyladenosine transferase-like protein; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      62387254..62403905 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      63206803..63223500 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)