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    TEKT2 tektin 2 [ Homo sapiens (human) ]

    Gene ID: 27285, updated on 17-Jun-2024

    Summary

    Official Symbol
    TEKT2provided by HGNC
    Official Full Name
    tektin 2provided by HGNC
    Primary source
    HGNC:HGNC:11725
    See related
    Ensembl:ENSG00000092850 MIM:608953; AllianceGenome:HGNC:11725
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TEKTB1; TEKTIN-T; h-tektin-t
    Summary
    This gene product belongs to the tektin family of proteins. Tektins comprise a family of filament-forming proteins that are coassembled with tubulins to form ciliary and flagellar microtubules. This gene is expressed in the testis and its protein is localized to the flagella of the sperms, indicating that it may play a role in spermatogenesis. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in testis (RPKM 21.9), lung (RPKM 4.1) and 1 other tissue See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TEKT2 in Genome Data Viewer
    Location:
    1p34.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (36084094..36088275)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (35946970..35951151)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (36549695..36553876)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene argonaute RISC catalytic component 3 Neighboring gene uncharacterized LOC105378647 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 741 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:36499894-36501093 Neighboring gene magnesium transporter 1 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:36550265-36551063 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:36553996-36554581 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:36554582-36555166 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:36563075-36563583 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 654 Neighboring gene ADP-ribosylserine hydrolase Neighboring gene collagen type VIII alpha 2 chain Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:36579590-36580530 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:36580531-36581471 Neighboring gene MPRA-validated peak176 silencer

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cilium movement involved in cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in flagellated sperm motility IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inner dynein arm assembly IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in axonemal A tubule inner sheath IEA
    Inferred from Electronic Annotation
    more info
     
    located_in axonemal microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axonemal microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in microtubule organizing center ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in motile cilium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus HDA PubMed 

    General protein information

    Preferred Names
    tektin-2
    Names
    tektin 2 (testicular)
    tektin-B1
    testicular tektin B1-like protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014466.3NP_055281.2  tektin-2

      See identical proteins and their annotated locations for NP_055281.2

      Status: REVIEWED

      Source sequence(s)
      AL138787
      Consensus CDS
      CCDS401.1
      UniProtKB/Swiss-Prot
      A6NIS6, O60638, Q9UIF3
      UniProtKB/TrEMBL
      B2R926
      Related
      ENSP00000207457.3, ENST00000207457.8
      Conserved Domains (1) summary
      pfam03148
      Location:17395
      Tektin; Tektin family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      36084094..36088275
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005270753.3XP_005270810.1  tektin-2 isoform X1

      See identical proteins and their annotated locations for XP_005270810.1

      UniProtKB/Swiss-Prot
      A6NIS6, O60638, Q9UIF3
      UniProtKB/TrEMBL
      B2R926
      Conserved Domains (1) summary
      pfam03148
      Location:17395
      Tektin; Tektin family
    2. XM_011541258.4XP_011539560.1  tektin-2 isoform X1

      See identical proteins and their annotated locations for XP_011539560.1

      UniProtKB/Swiss-Prot
      A6NIS6, O60638, Q9UIF3
      UniProtKB/TrEMBL
      B2R926
      Conserved Domains (1) summary
      pfam03148
      Location:17395
      Tektin; Tektin family
    3. XM_017001055.2XP_016856544.1  tektin-2 isoform X1

      UniProtKB/Swiss-Prot
      A6NIS6, O60638, Q9UIF3
      UniProtKB/TrEMBL
      B2R926
      Conserved Domains (1) summary
      pfam03148
      Location:17395
      Tektin; Tektin family

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      35946970..35951151
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054336049.1XP_054192024.1  tektin-2 isoform X1

      UniProtKB/Swiss-Prot
      A6NIS6, O60638, Q9UIF3
      UniProtKB/TrEMBL
      B2R926
    2. XM_054336050.1XP_054192025.1  tektin-2 isoform X1

      UniProtKB/Swiss-Prot
      A6NIS6, O60638, Q9UIF3
      UniProtKB/TrEMBL
      B2R926
    3. XM_054336051.1XP_054192026.1  tektin-2 isoform X1

      UniProtKB/Swiss-Prot
      A6NIS6, O60638, Q9UIF3
      UniProtKB/TrEMBL
      B2R926