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    SULT1B1 sulfotransferase family 1B member 1 [ Homo sapiens (human) ]

    Gene ID: 27284, updated on 5-Mar-2024

    Summary

    Official Symbol
    SULT1B1provided by HGNC
    Official Full Name
    sulfotransferase family 1B member 1provided by HGNC
    Primary source
    HGNC:HGNC:17845
    See related
    Ensembl:ENSG00000173597 MIM:608436; AllianceGenome:HGNC:17845
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ST1B1; ST1B2; SULT1B2
    Summary
    Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. However, the total genomic length of this gene is greater than that of other SULT1 genes. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in duodenum (RPKM 43.3), small intestine (RPKM 41.2) and 5 other tissues See more
    Orthologs
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    Genomic context

    See SULT1B1 in Genome Data Viewer
    Location:
    4q13.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (69721167..69760620, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (73055983..73095434, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (70586885..70626338, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene UDP glucuronosyltransferase family 2 member B7 pseudogene Neighboring gene MPRA-validated peak5055 silencer Neighboring gene UDP glucuronosyltransferase family 2 member A2 Neighboring gene UDP glucuronosyltransferase family 2 member A1 complex locus Neighboring gene MED14-independent group 3 enhancer GRCh37_chr4:70522042-70523241 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:70608551-70609050 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:70609253-70609754 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:70609755-70610254 Neighboring gene sulfotransferase family 1D member 1, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21599 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15467 Neighboring gene Sharpr-MPRA regulatory region 10246 Neighboring gene sulfotransferase family 1E member 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC13356

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables aryl sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables aryl sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    sulfotransferase 1B1
    Names
    sulfotransferase 1B2
    sulfotransferase family, cytosolic, 1B, member 1
    thyroid hormone sulfotransferase
    NP_055280.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014465.4NP_055280.2  sulfotransferase 1B1

      See identical proteins and their annotated locations for NP_055280.2

      Status: REVIEWED

      Source sequence(s)
      AC125239, BC010895, BG461453, U95726
      Consensus CDS
      CCDS3530.1
      UniProtKB/Swiss-Prot
      O15497, O43704, Q96FI1, Q9UK34
      Related
      ENSP00000308770.2, ENST00000310613.8
      Conserved Domains (1) summary
      pfam00685
      Location:38288
      Sulfotransfer_1; Sulfotransferase domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      69721167..69760620 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      73055983..73095434 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)