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    Plekhb1 pleckstrin homology domain containing, family B (evectins) member 1 [ Mus musculus (house mouse) ]

    Gene ID: 27276, updated on 6-Sep-2021

    Summary

    Official Symbol
    Plekhb1provided by MGI
    Official Full Name
    pleckstrin homology domain containing, family B (evectins) member 1provided by MGI
    Primary source
    MGI:MGI:1351469
    See related
    Ensembl:ENSMUSG00000030701
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PH; PHR1; Phre; evt-; evt-1; Phret1; AI315628
    Expression
    Biased expression in cerebellum adult (RPKM 133.7), cortex adult (RPKM 82.4) and 6 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Plekhb1 in Genome Data Viewer
    Location:
    7; 7 E2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (100291922..100311601, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (100643896..100662394, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (107792410..107810908, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L48 Neighboring gene cytochrome c oxidase assembly protein 20B Neighboring gene RAB6A, member RAS oncogene family Neighboring gene predicted gene, 53385 Neighboring gene predicted gene, 35082 Neighboring gene family with sequence similarity 168, member A Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein C-terminus binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in integral component of membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in photoreceptor outer segment TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    pleckstrin homology domain-containing family B member 1
    Names
    PH domain-containing family B member 1
    PH domain-containing protein in retina 1
    evectin-1
    pleckstrin homology domain retinal protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163182.1NP_001156654.1  pleckstrin homology domain-containing family B member 1 isoform b

      See identical proteins and their annotated locations for NP_001156654.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AC124531, BC024756, CD773826
      Consensus CDS
      CCDS52326.1
      UniProtKB/Swiss-Prot
      Q9QYE9
      Related
      ENSMUSP00000102662.3, ENSMUST00000107047.10
      Conserved Domains (2) summary
      cd13265
      Location:20127
      PH_evt; Evectin Pleckstrin homology (PH) domain
      pfam00169
      Location:22126
      PH; PH domain
    2. NM_001163183.1NP_001156655.1  pleckstrin homology domain-containing family B member 1 isoform c

      See identical proteins and their annotated locations for NP_001156655.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 3 and 6 both encode isoform c.
      Source sequence(s)
      BC024756, BY284567, CD773826, CX201870
      Consensus CDS
      CCDS52325.1
      UniProtKB/Swiss-Prot
      Q9QYE9
      Related
      ENSMUSP00000111991.3, ENSMUST00000116287.9
      Conserved Domains (1) summary
      cd13265
      Location:1108
      PH_evt; Evectin Pleckstrin homology (PH) domain
    3. NM_001163184.1NP_001156656.1  pleckstrin homology domain-containing family B member 1 isoform d

      See identical proteins and their annotated locations for NP_001156656.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (d) is shorter at the N-terminus and lacks an internal segment compared to isoform a. Variants 4, 5, and 7 all encode isoform d.
      Source sequence(s)
      AK005102, BY284567, CD773826
      Consensus CDS
      CCDS52324.1
      UniProtKB/Swiss-Prot
      Q9QYE9
      UniProtKB/TrEMBL
      Q3TP62
      Related
      ENSMUSP00000102659.4, ENSMUST00000107044.10
      Conserved Domains (1) summary
      cd13265
      Location:1108
      PH_evt; Evectin Pleckstrin homology (PH) domain
    4. NM_001163185.1NP_001156657.1  pleckstrin homology domain-containing family B member 1 isoform d

      See identical proteins and their annotated locations for NP_001156657.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (d) is shorter at the N-terminus and lacks an internal segment compared to isoform a. Variants 4, 5, and 7 all encode isoform d.
      Source sequence(s)
      AK005102, BY284567, CD773826
      Consensus CDS
      CCDS52324.1
      UniProtKB/Swiss-Prot
      Q9QYE9
      UniProtKB/TrEMBL
      Q3TP62
      Conserved Domains (1) summary
      cd13265
      Location:1108
      PH_evt; Evectin Pleckstrin homology (PH) domain
    5. NM_001163186.1NP_001156658.1  pleckstrin homology domain-containing family B member 1 isoform c

      See identical proteins and their annotated locations for NP_001156658.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 3 and 6 both encode isoform c.
      Source sequence(s)
      BC024756, BY255927, CD773826
      Consensus CDS
      CCDS52325.1
      UniProtKB/Swiss-Prot
      Q9QYE9
      Related
      ENSMUSP00000102660.2, ENSMUST00000107045.9
      Conserved Domains (1) summary
      cd13265
      Location:1108
      PH_evt; Evectin Pleckstrin homology (PH) domain
    6. NM_001163187.1NP_001156659.1  pleckstrin homology domain-containing family B member 1 isoform d

      See identical proteins and their annotated locations for NP_001156659.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (d) is shorter at the N-terminus and lacks an internal segment compared to isoform a. Variants 4, 5, and 7 all encode isoform d.
      Source sequence(s)
      BC024756, BY255927, CD773826
      Consensus CDS
      CCDS52324.1
      UniProtKB/Swiss-Prot
      Q9QYE9
      UniProtKB/TrEMBL
      Q3TP62
      Related
      ENSMUSP00000102661.2, ENSMUST00000107046.8
      Conserved Domains (1) summary
      cd13265
      Location:1108
      PH_evt; Evectin Pleckstrin homology (PH) domain
    7. NM_001291336.1NP_001278265.1  pleckstrin homology domain-containing family B member 1 isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR and coding sequence and lacks two alternate exons compared to variant 1, that causes a frameshift. The resulting isoform (e) is shorter at the N-terminus and has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AK005102, BY284567, CD776763
      Consensus CDS
      CCDS80756.1
      UniProtKB/Swiss-Prot
      Q9QYE9
      UniProtKB/TrEMBL
      D3YV71
      Related
      ENSMUSP00000102658.2, ENSMUST00000107043.8
      Conserved Domains (1) summary
      cd13265
      Location:197
      PH_evt; Evectin Pleckstrin homology (PH) domain
    8. NM_013746.3NP_038774.1  pleckstrin homology domain-containing family B member 1 isoform a

      See identical proteins and their annotated locations for NP_038774.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AC124531, BC024756, CD773826
      Consensus CDS
      CCDS21504.1
      UniProtKB/Swiss-Prot
      Q9QYE9
      Related
      ENSMUSP00000078175.7, ENSMUST00000079176.14
      Conserved Domains (2) summary
      cd13265
      Location:20127
      PH_evt; Evectin Pleckstrin homology (PH) domain
      pfam00169
      Location:22126
      PH; PH domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      100291922..100311601 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153147.1XP_036009040.1  pleckstrin homology domain-containing family B member 1 isoform X2

      Conserved Domains (1) summary
      cd13265
      Location:1108
      PH_evt; Evectin Pleckstrin homology (PH) domain
    2. XM_036153149.1XP_036009042.1  pleckstrin homology domain-containing family B member 1 isoform X3

      Conserved Domains (1) summary
      cd13265
      Location:197
      PH_evt; Evectin Pleckstrin homology (PH) domain
    3. XM_006507906.2XP_006507969.1  pleckstrin homology domain-containing family B member 1 isoform X1

      See identical proteins and their annotated locations for XP_006507969.1

      UniProtKB/Swiss-Prot
      Q9QYE9
      Conserved Domains (1) summary
      cd13265
      Location:1108
      PH_evt; Evectin Pleckstrin homology (PH) domain
    4. XM_036153148.1XP_036009041.1  pleckstrin homology domain-containing family B member 1 isoform X3

      Conserved Domains (1) summary
      cd13265
      Location:197
      PH_evt; Evectin Pleckstrin homology (PH) domain
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