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    ARHGEF16 Rho guanine nucleotide exchange factor 16 [ Homo sapiens (human) ]

    Gene ID: 27237, updated on 17-Jun-2024

    Summary

    Official Symbol
    ARHGEF16provided by HGNC
    Official Full Name
    Rho guanine nucleotide exchange factor 16provided by HGNC
    Primary source
    HGNC:HGNC:15515
    See related
    Ensembl:ENSG00000130762 MIM:618871; AllianceGenome:HGNC:15515
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NBR; GEF16
    Summary
    Although the specific function of this protein is not known yet, it is thought to be involved in protein-protein and protein-lipid interactions. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in duodenum (RPKM 15.0), small intestine (RPKM 12.9) and 17 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ARHGEF16 in Genome Data Viewer
    Location:
    1p36.32
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (3454665..3481113)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (2959327..2988135)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (3371229..3397677)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene PR/SET domain 16 Neighboring gene collagen alpha-5(IV) chain-like Neighboring gene VISTA enhancer hs705 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:3191818-3193017 Neighboring gene Sharpr-MPRA regulatory region 1987 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3212462-3212962 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:3215870-3217069 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_6721 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3220731-3221288 Neighboring gene uncharacterized LOC105378604 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:3229262-3230461 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr1:3231799-3232358 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3235695-3236196 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3236197-3236696 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3237397-3238015 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3246879-3247556 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3255514-3256329 Neighboring gene VISTA enhancer hs1912 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3268668-3269642 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3269643-3270616 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3272921-3273812 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3273813-3274702 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3277409-3277908 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:3285513-3286094 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3303704-3304204 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3304205-3304705 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3307961-3308462 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3311898-3312581 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3312582-3313264 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3320127-3320627 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3325025-3325602 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3332377-3333072 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3331680-3332376 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3337228-3337728 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3350015-3350524 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3357159-3357921 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3369311-3370063 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3373825-3374576 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_7120 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3388131-3388756 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3399659-3400494 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3400495-3401329 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 120 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3408710-3409234 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3408184-3408709 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 119 Neighboring gene MEGF6 intron CAGE-defined mid-level expression enhancer Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_7326 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3439723-3440262 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3445841-3446528 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3447217-3447902 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3449965-3450651 Neighboring gene multiple EGF like domains 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3459643-3460294 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3460295-3460948 Neighboring gene MPRA-validated peak19 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3463961-3464599 Neighboring gene uncharacterized LOC105378608 Neighboring gene microRNA 551a

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association of lipid-lowering response to statins in combined study populations.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    rho guanine nucleotide exchange factor 16
    Names
    Rho guanine exchange factor (GEF) 16
    Rho guanine nucleotide exchange factor (GEF) 16
    ephexin-4
    ephexin4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014448.4NP_055263.2  rho guanine nucleotide exchange factor 16

      See identical proteins and their annotated locations for NP_055263.2

      Status: REVIEWED

      Source sequence(s)
      AL512413
      Consensus CDS
      CCDS46.2
      UniProtKB/Swiss-Prot
      Q5VV41, Q86TF0, Q99434
      UniProtKB/TrEMBL
      A0A2X0SFX5, B3KTS4
      Related
      ENSP00000367629.4, ENST00000378378.9
      Conserved Domains (4) summary
      cd11938
      Location:633686
      SH3_ARHGEF16_26; Src homology 3 domain of the Rho guanine nucleotide exchange factors ARHGEF16 and ARHGEF26
      cd01221
      Location:489622
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
      pfam00169
      Location:501620
      PH; PH domain
      pfam00621
      Location:288467
      RhoGEF; RhoGEF domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      3454665..3481113
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017001051.2XP_016856540.1  rho guanine nucleotide exchange factor 16 isoform X2

      UniProtKB/Swiss-Prot
      Q5VV41, Q86TF0, Q99434
      UniProtKB/TrEMBL
      A0A2X0SFX5, B3KTS4
      Conserved Domains (4) summary
      cd11938
      Location:633686
      SH3_ARHGEF16_26; Src homology 3 domain of the Rho guanine nucleotide exchange factors ARHGEF16 and ARHGEF26
      cd01221
      Location:489622
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
      pfam00169
      Location:501620
      PH; PH domain
      pfam00621
      Location:288467
      RhoGEF; RhoGEF domain
    2. XM_017001049.2XP_016856538.1  rho guanine nucleotide exchange factor 16 isoform X1

      UniProtKB/TrEMBL
      A0A2X0SFX5
    3. XM_047418009.1XP_047273965.1  rho guanine nucleotide exchange factor 16 isoform X4

    4. XM_024446454.2XP_024302222.1  rho guanine nucleotide exchange factor 16 isoform X3

      UniProtKB/TrEMBL
      B4DJM7
      Related
      ENSP00000367624.1, ENST00000378373.5
      Conserved Domains (3) summary
      cd11938
      Location:345398
      SH3_ARHGEF16_26; Src homology 3 domain of the Rho guanine nucleotide exchange factors ARHGEF16 and ARHGEF26
      cd01221
      Location:201334
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
      pfam00621
      Location:1178
      RhoGEF; RhoGEF domain
    5. XM_024446455.2XP_024302223.1  rho guanine nucleotide exchange factor 16 isoform X3

      UniProtKB/TrEMBL
      B4DJM7
      Related
      ENSP00000367622.2, ENST00000378371.6
      Conserved Domains (3) summary
      cd11938
      Location:345398
      SH3_ARHGEF16_26; Src homology 3 domain of the Rho guanine nucleotide exchange factors ARHGEF16 and ARHGEF26
      cd01221
      Location:201334
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
      pfam00621
      Location:1178
      RhoGEF; RhoGEF domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      2959327..2988135
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054336013.1XP_054191988.1  rho guanine nucleotide exchange factor 16 isoform X2

      UniProtKB/TrEMBL
      B3KTS4
    2. XM_054336012.1XP_054191987.1  rho guanine nucleotide exchange factor 16 isoform X1

      UniProtKB/TrEMBL
      B3KTS4
    3. XM_054336016.1XP_054191991.1  rho guanine nucleotide exchange factor 16 isoform X5

    4. XM_054336014.1XP_054191989.1  rho guanine nucleotide exchange factor 16 isoform X3

      UniProtKB/TrEMBL
      B4DJM7
    5. XM_054336015.1XP_054191990.1  rho guanine nucleotide exchange factor 16 isoform X3

      UniProtKB/TrEMBL
      B4DJM7