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    Trp53bp1 transformation related protein 53 binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 27223, updated on 14-Sep-2021

    Summary

    Official Symbol
    Trp53bp1provided by MGI
    Official Full Name
    transformation related protein 53 binding protein 1provided by MGI
    Primary source
    MGI:MGI:1351320
    See related
    Ensembl:ENSMUSG00000043909
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    53BP; p53B; 53BP1; m53BP1; p53BP1; Tp53bp1
    Expression
    Broad expression in CNS E14 (RPKM 21.5), whole brain E14.5 (RPKM 20.5) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Trp53bp1 in Genome Data Viewer
    Location:
    2; 2 E5
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (121025316..121126830, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (121194835..121296354, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (121022463..121097122, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene leucine carboxyl methyltransferase 2 Neighboring gene adenosine deaminase-like Neighboring gene zinc finger SCAN domains 29 Neighboring gene tubulin, gamma complex associated protein 4 Neighboring gene microtubule-associated protein 1 A Neighboring gene diphosphoinositol pentakisphosphate kinase 1 Neighboring gene predicted gene, 33947 Neighboring gene creatine kinase, mitochondrial 1, ubiquitous

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC100303

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables damaged DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables methylated histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables p53 binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables telomeric DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription coregulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription factor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables ubiquitin modification-dependent histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within DNA repair IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in double-strand break repair via nonhomologous end joining IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in double-strand break repair via nonhomologous end joining IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in double-strand break repair via nonhomologous end joining ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of double-strand break repair via homologous recombination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of isotype switching IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of isotype switching ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of transcription, DNA-templated TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of DNA repair complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in replication fork IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in site of double-strand break IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    TP53-binding protein 1
    Names
    murine p53-binding protein
    p53-binding protein 1
    tumor suppressor p53-binding protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290830.1NP_001277759.1  TP53-binding protein 1 isoform b

      See identical proteins and their annotated locations for NP_001277759.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
      Source sequence(s)
      AK036324, AK045416, AK132323, BC079906, BY777325, CA316961, CA752558, CF744583
      Consensus CDS
      CCDS71125.1
      UniProtKB/Swiss-Prot
      P70399
      UniProtKB/TrEMBL
      Q3V1P7, Q8BZ87
      Related
      ENSMUSP00000106277.2, ENSMUST00000110647.8
      Conserved Domains (4) summary
      COG5271
      Location:563890
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      cd17745
      Location:16751786
      BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins
      pfam09038
      Location:14311551
      53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor
      pfam18428
      Location:18141917
      BRCT_3; BRCA1 C Terminus (BRCT) domain
    2. NM_013735.4NP_038763.3  TP53-binding protein 1 isoform a

      See identical proteins and their annotated locations for NP_038763.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a). This variant is supported by the 5'-partial mRNA AJ414734.1, with inference of the first exon from other transcript alignments.
      Source sequence(s)
      AK036324, AK045416, AK132323, BC079906, BY777325, CA316961, CA752558, CF744583
      Consensus CDS
      CCDS50684.1
      UniProtKB/Swiss-Prot
      P70399
      UniProtKB/TrEMBL
      Q3V1P7, Q8BZ87
      Related
      ENSMUSP00000106278.2, ENSMUST00000110648.8
      Conserved Domains (4) summary
      COG5271
      Location:563890
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      cd17745
      Location:17251836
      BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins
      pfam09038
      Location:14811601
      53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor
      pfam18428
      Location:18641967
      BRCT_3; BRCA1 C Terminus (BRCT) domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      121025316..121126830 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251686.2XP_030107546.1  TP53-binding protein 1 isoform X1

      Conserved Domains (4) summary
      COG5271
      Location:563890
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      cd17745
      Location:17251836
      BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins
      pfam09038
      Location:14811601
      53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor
      pfam18428
      Location:18641967
      BRCT_3; BRCA1 C Terminus (BRCT) domain
    2. XM_036162270.1XP_036018163.1  TP53-binding protein 1 isoform X13

      Conserved Domains (4) summary
      COG5271
      Location:333792
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      cd17745
      Location:14531564
      BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins
      pfam09038
      Location:12111331
      53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor
      pfam18428
      Location:15921695
      BRCT_3; BRCA1 C Terminus (BRCT) domain
    3. XM_017318937.3XP_017174426.1  TP53-binding protein 1 isoform X11

      Conserved Domains (4) summary
      COG5271
      Location:5631022
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      cd17745
      Location:16351746
      BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins
      pfam09038
      Location:13911511
      53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor
      pfam18428
      Location:17741877
      BRCT_3; BRCA1 C Terminus (BRCT) domain
    4. XM_017318936.3XP_017174425.1  TP53-binding protein 1 isoform X7

      Conserved Domains (4) summary
      COG5271
      Location:5631022
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      cd17745
      Location:16831794
      BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins
      pfam09038
      Location:14411561
      53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor
      pfam18428
      Location:18221925
      BRCT_3; BRCA1 C Terminus (BRCT) domain
    5. XM_036162266.1XP_036018159.1  TP53-binding protein 1 isoform X5

      Conserved Domains (4) summary
      COG5271
      Location:563890
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      cd17745
      Location:16921803
      BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins
      pfam09038
      Location:14501570
      53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor
      pfam18428
      Location:18311934
      BRCT_3; BRCA1 C Terminus (BRCT) domain
    6. XM_036162267.1XP_036018160.1  TP53-binding protein 1 isoform X9

      Conserved Domains (4) summary
      COG5271
      Location:563890
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      cd17745
      Location:16731784
      BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins
      pfam09038
      Location:14311551
      53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor
      pfam18428
      Location:18121915
      BRCT_3; BRCA1 C Terminus (BRCT) domain
    7. XM_011239584.4XP_011237886.1  TP53-binding protein 1 isoform X8

      See identical proteins and their annotated locations for XP_011237886.1

      Conserved Domains (4) summary
      COG5271
      Location:563890
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      cd17745
      Location:16751786
      BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins
      pfam09038
      Location:14311551
      53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor
      pfam18428
      Location:18141917
      BRCT_3; BRCA1 C Terminus (BRCT) domain
    8. XM_006499661.5XP_006499724.1  TP53-binding protein 1 isoform X2

      Conserved Domains (4) summary
      COG5271
      Location:563890
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      cd17745
      Location:17231834
      BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins
      pfam09038
      Location:14811601
      53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor
      pfam18428
      Location:18621965
      BRCT_3; BRCA1 C Terminus (BRCT) domain
    9. XM_011239581.4XP_011237883.1  TP53-binding protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011237883.1

      UniProtKB/Swiss-Prot
      P70399
      Conserved Domains (4) summary
      COG5271
      Location:563890
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      cd17745
      Location:17251836
      BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins
      pfam09038
      Location:14811601
      53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor
      pfam18428
      Location:18641967
      BRCT_3; BRCA1 C Terminus (BRCT) domain
    10. XM_030251685.2XP_030107545.1  TP53-binding protein 1 isoform X1

      Conserved Domains (4) summary
      COG5271
      Location:563890
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      cd17745
      Location:17251836
      BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins
      pfam09038
      Location:14811601
      53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor
      pfam18428
      Location:18641967
      BRCT_3; BRCA1 C Terminus (BRCT) domain
    11. XM_036162268.1XP_036018161.1  TP53-binding protein 1 isoform X10

      Conserved Domains (4) summary
      COG5271
      Location:491818
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      cd17745
      Location:16531764
      BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins
      pfam09038
      Location:14091529
      53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor
      pfam18428
      Location:17921895
      BRCT_3; BRCA1 C Terminus (BRCT) domain
    12. XM_036162269.1XP_036018162.1  TP53-binding protein 1 isoform X12

      Conserved Domains (4) summary
      COG5271
      Location:333660
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      cd17745
      Location:14951606
      BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins
      pfam09038
      Location:12511371
      53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor
      pfam18428
      Location:16341737
      BRCT_3; BRCA1 C Terminus (BRCT) domain
    13. XM_030251687.2XP_030107547.1  TP53-binding protein 1 isoform X12

      Conserved Domains (4) summary
      COG5271
      Location:333660
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      cd17745
      Location:14951606
      BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins
      pfam09038
      Location:12511371
      53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor
      pfam18428
      Location:16341737
      BRCT_3; BRCA1 C Terminus (BRCT) domain
    14. XM_011239583.4XP_011237885.1  TP53-binding protein 1 isoform X6

      Conserved Domains (4) summary
      COG5271
      Location:5631022
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      cd17745
      Location:16851796
      BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins
      pfam09038
      Location:14411561
      53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor
      pfam18428
      Location:18241927
      BRCT_3; BRCA1 C Terminus (BRCT) domain
    15. XM_011239582.4XP_011237884.1  TP53-binding protein 1 isoform X4

      Conserved Domains (4) summary
      COG5271
      Location:563890
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      cd17745
      Location:16941805
      BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins
      pfam09038
      Location:14501570
      53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor
      pfam18428
      Location:18331936
      BRCT_3; BRCA1 C Terminus (BRCT) domain
    16. XM_030251688.1XP_030107548.1  TP53-binding protein 1 isoform X14

      Conserved Domains (4) summary
      COG5271
      Location:170497
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      cd17745
      Location:13321443
      BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins
      pfam09038
      Location:10881208
      53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor
      pfam18428
      Location:14711574
      BRCT_3; BRCA1 C Terminus (BRCT) domain
    17. XM_006499662.5XP_006499725.1  TP53-binding protein 1 isoform X3

      Conserved Domains (4) summary
      COG5271
      Location:558885
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      cd17745
      Location:17201831
      BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins
      pfam09038
      Location:14761596
      53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor
      pfam18428
      Location:18591962
      BRCT_3; BRCA1 C Terminus (BRCT) domain
    18. XM_006499668.5XP_006499731.1  TP53-binding protein 1 isoform X16

      Conserved Domains (3) summary
      cd17745
      Location:776887
      BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins
      pfam09038
      Location:532652
      53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor
      pfam18428
      Location:9151018
      BRCT_3; BRCA1 C Terminus (BRCT) domain
    19. XM_011239585.4XP_011237887.1  TP53-binding protein 1 isoform X15

      Related
      ENSMUSP00000114457.2, ENSMUST00000131245.2

    RNA

    1. XR_004940621.1 RNA Sequence

    2. XR_003953350.2 RNA Sequence

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