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    Trp53bp1 transformation related protein 53 binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 27223, updated on 9-Oct-2018

    Summary

    Official Symbol
    Trp53bp1provided by MGI
    Official Full Name
    transformation related protein 53 binding protein 1provided by MGI
    Primary source
    MGI:MGI:1351320
    See related
    Ensembl:ENSMUSG00000043909 Vega:OTTMUSG00000015973
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    53BP1; m53BP1; p53BP1; Tp53bp1
    Expression
    Broad expression in CNS E14 (RPKM 21.5), whole brain E14.5 (RPKM 20.5) and 24 other tissues See more
    Orthologs

    Genomic context

    See Trp53bp1 in Genome Data Viewer
    Location:
    2; 2 E5
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (121194835..121290325, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (121022463..121097122, complement)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene leucine carboxyl methyltransferase 2 Neighboring gene adenosine deaminase-like Neighboring gene zinc finger SCAN domains 29 Neighboring gene tubulin, gamma complex associated protein 4 Neighboring gene microtubule-associated protein 1 A Neighboring gene diphosphoinositol pentakisphosphate kinase 1 Neighboring gene predicted gene, 33947 Neighboring gene creatine kinase, mitochondrial 1, ubiquitous

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC100303

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II activating transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    damaged DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    methylated histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    p53 binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    telomeric DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription coregulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    ubiquitin modification-dependent histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    DNA damage checkpoint IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA repair IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    double-strand break repair via nonhomologous end joining IDA
    Inferred from Direct Assay
    more info
    PubMed 
    double-strand break repair via nonhomologous end joining IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    double-strand break repair via nonhomologous end joining ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of double-strand break repair via homologous recombination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of isotype switching IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of isotype switching ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    DNA repair complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    replication fork IDA
    Inferred from Direct Assay
    more info
    PubMed 
    site of double-strand break IDA
    Inferred from Direct Assay
    more info
    PubMed 
    site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    TP53-binding protein 1; tumor suppressor p53-binding protein 1
    Names
    murine p53-binding protein
    p53-binding protein 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290830.1NP_001277759.1  TP53-binding protein 1 isoform b

      See identical proteins and their annotated locations for NP_001277759.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
      Source sequence(s)
      AK036324, AK045416, AK132323, BC079906, BY777325, CA316961, CA752558, CF744583
      Consensus CDS
      CCDS71125.1
      UniProtKB/Swiss-Prot
      P70399
      UniProtKB/TrEMBL
      Q3V1P7, Q8BZ87
      Related
      ENSMUSP00000106277.1, OTTMUSP00000017048, ENSMUST00000110647.7, OTTMUST00000038006
      Conserved Domains (2) summary
      smart00292
      Location:18131898
      BRCT; breast cancer carboxy-terminal domain
      pfam09038
      Location:14311551
      53-BP1_Tudor; Tumour suppressor p53-binding protein-1 Tudor
    2. NM_013735.4NP_038763.3  TP53-binding protein 1 isoform a

      See identical proteins and their annotated locations for NP_038763.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a). This variant is supported by the 5'-partial mRNA AJ414734.1, with inference of the first exon from other transcript alignments.
      Source sequence(s)
      AK036324, AK045416, AK132323, BC079906, BY777325, CA316961, CA752558, CF744583
      Consensus CDS
      CCDS50684.1
      UniProtKB/Swiss-Prot
      P70399
      UniProtKB/TrEMBL
      Q3V1P7, Q8BZ87
      Related
      ENSMUSP00000106278.1, OTTMUSP00000017066, ENSMUST00000110648.7, OTTMUST00000038042
      Conserved Domains (3) summary
      smart00292
      Location:18631948
      BRCT; breast cancer carboxy-terminal domain
      pfam09038
      Location:14811601
      53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor
      cl26761
      Location:563890
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      121194835..121290325 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017318937.1XP_017174426.1  tumor suppressor p53-binding protein 1 isoform X8

    2. XM_011239584.2XP_011237886.1  tumor suppressor p53-binding protein 1 isoform X7

      See identical proteins and their annotated locations for XP_011237886.1

      Conserved Domains (2) summary
      smart00292
      Location:18131898
      BRCT; breast cancer carboxy-terminal domain
      pfam09038
      Location:14311551
      53-BP1_Tudor; Tumour suppressor p53-binding protein-1 Tudor
    3. XM_017318936.1XP_017174425.1  tumor suppressor p53-binding protein 1 isoform X6

    4. XM_011239582.2XP_011237884.1  tumor suppressor p53-binding protein 1 isoform X4

      Conserved Domains (2) summary
      smart00292
      Location:18321917
      BRCT; breast cancer carboxy-terminal domain
      pfam09038
      Location:14501570
      53-BP1_Tudor; Tumour suppressor p53-binding protein-1 Tudor
    5. XM_006499661.3XP_006499724.1  tumor suppressor p53-binding protein 1 isoform X2

      Conserved Domains (2) summary
      smart00292
      Location:18611946
      BRCT; breast cancer carboxy-terminal domain
      pfam09038
      Location:14811601
      53-BP1_Tudor; Tumour suppressor p53-binding protein-1 Tudor
    6. XM_011239581.2XP_011237883.1  tumor suppressor p53-binding protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011237883.1

      UniProtKB/Swiss-Prot
      P70399
      Conserved Domains (3) summary
      smart00292
      Location:18631948
      BRCT; breast cancer carboxy-terminal domain
      pfam09038
      Location:14811601
      53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor
      cl26761
      Location:563890
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    7. XM_006499662.3XP_006499725.1  tumor suppressor p53-binding protein 1 isoform X3

      Conserved Domains (2) summary
      smart00292
      Location:18581943
      BRCT; breast cancer carboxy-terminal domain
      pfam09038
      Location:14761596
      53-BP1_Tudor; Tumour suppressor p53-binding protein-1 Tudor
    8. XM_006499666.3XP_006499729.1  tumor suppressor p53-binding protein 1 isoform X10

      Conserved Domains (2) summary
      smart00292
      Location:16331718
      BRCT; breast cancer carboxy-terminal domain
      pfam09038
      Location:12511371
      53-BP1_Tudor; Tumour suppressor p53-binding protein-1 Tudor
    9. XM_006499667.3XP_006499730.1  tumor suppressor p53-binding protein 1 isoform X11

      Conserved Domains (2) summary
      smart00292
      Location:14701555
      BRCT; breast cancer carboxy-terminal domain
      pfam09038
      Location:10881208
      53-BP1_Tudor; Tumour suppressor p53-binding protein-1 Tudor
    10. XM_006499668.3XP_006499731.1  tumor suppressor p53-binding protein 1 isoform X13

      Conserved Domains (2) summary
      smart00292
      Location:914999
      BRCT; breast cancer carboxy-terminal domain
      pfam09038
      Location:532652
      53-BP1_Tudor; Tumour suppressor p53-binding protein-1 Tudor
    11. XM_011239583.2XP_011237885.1  tumor suppressor p53-binding protein 1 isoform X5

      Conserved Domains (2) summary
      smart00292
      Location:18231908
      BRCT; breast cancer carboxy-terminal domain
      pfam09038
      Location:14411561
      53-BP1_Tudor; Tumour suppressor p53-binding protein-1 Tudor
    12. XM_017318938.1XP_017174427.1  tumor suppressor p53-binding protein 1 isoform X9

    13. XM_011239585.2XP_011237887.1  tumor suppressor p53-binding protein 1 isoform X12

      Related
      ENSMUSP00000114457.1, OTTMUSP00000017065, ENSMUST00000131245.1, OTTMUST00000038041
      Conserved Domains (1) summary
      COG5271
      Location:563890
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

    RNA

    1. XR_866288.2 RNA Sequence

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