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    Dbf4 DBF4 zinc finger [ Mus musculus (house mouse) ]

    Gene ID: 27214, updated on 31-Jan-2019

    Summary

    Official Symbol
    Dbf4provided by MGI
    Official Full Name
    DBF4 zinc fingerprovided by MGI
    Primary source
    MGI:MGI:1351328
    See related
    Ensembl:ENSMUSG00000002297
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ask; AA545217
    Expression
    Broad expression in CNS E11.5 (RPKM 20.9), liver E14 (RPKM 16.1) and 15 other tissues See more
    Orthologs

    Genomic context

    See Dbf4 in Genome Data Viewer
    Location:
    5; 5 A1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (8396969..8422723, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (8397011..8422606, complement)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene a disintegrin and metallopeptidase domain 22 Neighboring gene predicted gene, 21759 Neighboring gene ribosomal protein L19 pseudogene Neighboring gene solute carrier family 25, member 40 Neighboring gene RUN domain containing 3B Neighboring gene ATP-binding cassette, sub-family B (MDR/TAP), member 1A

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein serine/threonine kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein serine/threonine kinase activity ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    DNA replication IEA
    Inferred from Electronic Annotation
    more info
     
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    traversing start control point of mitotic cell cycle ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    Component Evidence Code Pubs
    Dbf4-dependent protein kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein DBF4 homolog A
    Names
    DBF4 homolog
    activator of S phase kinase

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190717.1NP_001177646.1  protein DBF4 homolog A isoform 2

      See identical proteins and their annotated locations for NP_001177646.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC152165, AK132403, BB611145
      Consensus CDS
      CCDS57324.1
      UniProtKB/Swiss-Prot
      Q9QZ41
      Related
      ENSMUSP00000002368.9, ENSMUST00000002368.15
      Conserved Domains (2) summary
      cd00027
      Location:4892
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
      cl02684
      Location:287334
      zf-DBF; DBF zinc finger
    2. NM_013726.3NP_038754.1  protein DBF4 homolog A isoform 1

      See identical proteins and their annotated locations for NP_038754.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC152165, AK132403, BB611145, BC138709
      Consensus CDS
      CCDS19081.1
      UniProtKB/Swiss-Prot
      Q9QZ41
      UniProtKB/TrEMBL
      B2RS44
      Related
      ENSMUSP00000132906.1, ENSMUST00000171808.7
      Conserved Domains (2) summary
      cd00027
      Location:4892
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
      cl02684
      Location:288335
      zf-DBF; DBF zinc finger

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      8396969..8422723 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011240670.2XP_011238972.1  protein DBF4 homolog A isoform X1

      Conserved Domains (1) summary
      cd00027
      Location:4894
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
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