Format

Send to:

Choose Destination
    • Showing Current items.

    Tbck TBC1 domain containing kinase [ Mus musculus (house mouse) ]

    Gene ID: 271981, updated on 31-Jan-2019

    Summary

    Official Symbol
    Tbckprovided by MGI
    Official Full Name
    TBC1 domain containing kinaseprovided by MGI
    Primary source
    MGI:MGI:2445052
    See related
    Ensembl:ENSMUSG00000028030
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tbckl; 9430001M19; 1700120J03Rik; A630047E20Rik; C030007I09Rik
    Expression
    Ubiquitous expression in kidney adult (RPKM 2.2), whole brain E14.5 (RPKM 2.1) and 28 other tissues See more
    Orthologs

    Genomic context

    See Tbck in Genome Data Viewer
    Location:
    3; 3 G3
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (132683992..132841688)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (132347108..132501470)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene predicted gene 9402 Neighboring gene aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 Neighboring gene predicted gene, 30294 Neighboring gene predicted gene, 29811 Neighboring gene heat shock protein 90 alpha (cytosolic), class B member 1 pseudogene Neighboring gene nephronectin

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NOT ATP binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Rab GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    NOT protein kinase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    activation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    NOT protein phosphorylation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    midbody ISO
    Inferred from Sequence Orthology
    more info
     
    mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    TBC domain-containing protein kinase-like protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163455.2NP_001156927.1  TBC domain-containing protein kinase-like protein

      Status: VALIDATED

      Source sequence(s)
      AC135118, AC139942, AK007218, AK034533, AK081215, CN720994
      Consensus CDS
      CCDS51070.1
      UniProtKB/Swiss-Prot
      Q8BM85
      UniProtKB/TrEMBL
      E9Q1W7
      Related
      ENSMUSP00000129205.1, ENSMUST00000169172.4
      Conserved Domains (4) summary
      smart00164
      Location:467671
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      smart00220
      Location:43273
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl00125
      Location:771882
      RHOD; Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins ...
      cl21453
      Location:43271
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

      Range
      132683992..132841688
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501553.3XP_006501616.1  TBC domain-containing protein kinase-like protein isoform X2

      Conserved Domains (3) summary
      smart00164
      Location:467671
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      smart00220
      Location:43273
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:43271
      PKc_like; Protein Kinases, catalytic domain
    2. XM_006501552.2XP_006501615.1  TBC domain-containing protein kinase-like protein isoform X1

      Conserved Domains (3) summary
      smart00164
      Location:328532
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd01525
      Location:632743
      RHOD_Kc; Member of the Rhodanese Homology Domain superfamily. Included in this CD are the rhodanese-like domains found C-terminal of the serine/threonine protein kinases catalytic (S_TKc) domain and the Tre-2, BUB2p, Cdc16p (TBC) domain. The putative active site ...
      cl21453
      Location:12130
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_001783696.1 RNA Sequence

    2. XR_001783695.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_173032.3: Suppressed sequence

      Description
      NM_173032.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein, and the transcript appears incomplete at the 3' end.
    Support Center