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    IL36B interleukin 36 beta [ Homo sapiens (human) ]

    Gene ID: 27177, updated on 5-Mar-2024

    Summary

    Official Symbol
    IL36Bprovided by HGNC
    Official Full Name
    interleukin 36 betaprovided by HGNC
    Primary source
    HGNC:HGNC:15564
    See related
    Ensembl:ENSG00000136696 MIM:605508; AllianceGenome:HGNC:15564
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FIL1; FIL1H; IL1F8; IL1H2; IL-1F8; IL-1H2; IL1-ETA; FIL1-(ETA); FILI-(ETA)
    Summary
    The protein encoded by this gene is a member of the interleukin 1 cytokine family. Protein structure modeling indicated that this cytokine may contain a 12-stranded beta-trefoil structure that is conserved between IL1A (IL-A alpha) and IL1B (IL-1 beta). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in skin (RPKM 1.1) and esophagus (RPKM 0.5) See more
    Orthologs
    NEW
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    Genomic context

    See IL36B in Genome Data Viewer
    Location:
    2q14.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (113022089..113052867, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (113448613..113479393, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (113779666..113810444, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16409 Neighboring gene POLR2D pseudogene 1 Neighboring gene interleukin 36 alpha Neighboring gene Sharpr-MPRA regulatory region 4990 Neighboring gene interleukin 36 receptor antagonist Neighboring gene interleukin 1 family member 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC126880, MGC126882

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables interleukin-1 receptor binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to lipopolysaccharide IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in immune response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in inflammatory response to antigenic stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of T cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    interleukin-36 beta
    Names
    FIL1 eta
    IL-1 eta
    IL-1F8 (FIL1-eta)
    Interleukin-1 Superfamily e
    family of interleukin 1-eta
    interleukin 1 family, member 8 (eta)
    interleukin-1 eta
    interleukin-1 family member 8
    interleukin-1 homolog 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014438.5NP_055253.2  interleukin-36 beta isoform 1

      See identical proteins and their annotated locations for NP_055253.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes a longer isoform (1).
      Source sequence(s)
      AC016724, AF200494
      Consensus CDS
      CCDS2109.1
      UniProtKB/Swiss-Prot
      Q3MIH0, Q53SR6, Q7RTZ7, Q9NZH7, Q9UHA5
      Related
      ENSP00000259213.4, ENST00000259213.9
      Conserved Domains (1) summary
      cl00094
      Location:1287
      IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
    2. NM_173178.3NP_775270.1  interleukin-36 beta isoform 2

      See identical proteins and their annotated locations for NP_775270.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' region, which includes a part of the coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a distinct and shorter C-terminus, as compared to isoform 1.
      Source sequence(s)
      AC016724, AF201833, CA441070
      Consensus CDS
      CCDS2110.1
      UniProtKB/Swiss-Prot
      Q9NZH7
      Related
      ENSP00000328420.2, ENST00000327407.2
      Conserved Domains (1) summary
      cl00094
      Location:12153
      IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      113022089..113052867 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011510962.1XP_011509264.1  interleukin-36 beta isoform X1

      See identical proteins and their annotated locations for XP_011509264.1

      UniProtKB/Swiss-Prot
      Q9NZH7
      Conserved Domains (1) summary
      cl00094
      Location:12153
      IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      113448613..113479393 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054341386.1XP_054197361.1  interleukin-36 beta isoform X1