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    Zbtb11 zinc finger and BTB domain containing 11 [ Mus musculus (house mouse) ]

    Gene ID: 271377, updated on 18-Sep-2024

    Summary

    Official Symbol
    Zbtb11provided by MGI
    Official Full Name
    zinc finger and BTB domain containing 11provided by MGI
    Primary source
    MGI:MGI:2443876
    See related
    Ensembl:ENSMUSG00000022601 AllianceGenome:MGI:2443876
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ZNF-U69274; 9230110G02Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be located in nucleoplasm. Is expressed in genitourinary system and inner ear. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human ZBTB11 (zinc finger and BTB domain containing 11). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 7.2), cerebellum adult (RPKM 5.4) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Zbtb11 in Genome Data Viewer
    Location:
    16 C1.1; 16 33.74 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (55791820..55829276)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (55971437..56008913)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_41050 Neighboring gene STARR-positive B cell enhancer ABC_E2466 Neighboring gene predicted gene 6958 Neighboring gene STARR-positive B cell enhancer ABC_E4180 Neighboring gene ribosomal protein L24 Neighboring gene zinc finger and BTB domain containing 11, opposite strand 1 Neighboring gene STARR-seq mESC enhancer starr_41052 Neighboring gene PEST proteolytic signal containing nuclear protein Neighboring gene STARR-positive B cell enhancer ABC_E10912 Neighboring gene tRNA methyltransferase 10C, mitochondrial RNase P subunit Neighboring gene predicted gene, 22422

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    zinc finger and BTB domain-containing protein 11

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173026.2NP_766614.2  zinc finger and BTB domain-containing protein 11

      See identical proteins and their annotated locations for NP_766614.2

      Status: VALIDATED

      Source sequence(s)
      AC171202
      Consensus CDS
      CCDS49874.1
      UniProtKB/Swiss-Prot
      G5E8B9, Q8BZQ5
      Related
      ENSMUSP00000056923.8, ENSMUST00000050248.9
      Conserved Domains (6) summary
      COG5048
      Location:664837
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:678698
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18202
      Location:195312
      BTB_POZ_ZBTB11; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11)
      pfam13465
      Location:897920
      zf-H2C2_2; Zinc-finger double domain
      pfam17921
      Location:68120
      Integrase_H2C2; Integrase zinc binding domain
      cl29137
      Location:367421
      Trypan_PARP; Procyclic acidic repetitive protein (PARP)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      55791820..55829276
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159968.1XP_036015861.1  zinc finger and BTB domain-containing protein 11 isoform X1

      Conserved Domains (6) summary
      PRK12387
      Location:554621
      PRK12387; formate hydrogenlyase complex iron-sulfur subunit; Provisional
      sd00017
      Location:848868
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18202
      Location:195312
      BTB_POZ_ZBTB11; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11)
      pfam13465
      Location:888911
      zf-H2C2_2; Zinc-finger double domain
      pfam17921
      Location:68120
      Integrase_H2C2; Integrase zinc binding domain
      NF033845
      Location:371502
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
    2. XM_030249142.2XP_030105002.1  zinc finger and BTB domain-containing protein 11 isoform X2

      Conserved Domains (7) summary
      PRK12387
      Location:554621
      PRK12387; formate hydrogenlyase complex iron-sulfur subunit; Provisional
      COG5189
      Location:667752
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:678698
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18202
      Location:195312
      BTB_POZ_ZBTB11; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11)
      pfam13465
      Location:662687
      zf-H2C2_2; Zinc-finger double domain
      pfam17921
      Location:68120
      Integrase_H2C2; Integrase zinc binding domain
      cl29137
      Location:367421
      Trypan_PARP; Procyclic acidic repetitive protein (PARP)
    3. XM_036159969.1XP_036015862.1  zinc finger and BTB domain-containing protein 11 isoform X3

      Conserved Domains (5) summary
      COG5048
      Location:380553
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:394414
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl38908
      Location:128
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam13465
      Location:613636
      zf-H2C2_2; Zinc-finger double domain
      NF033845
      Location:87218
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

    RNA

    1. XR_001781828.3 RNA Sequence

    2. XR_004939192.1 RNA Sequence