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    Mbtps2 membrane-bound transcription factor peptidase, site 2 [ Mus musculus (house mouse) ]

    Gene ID: 270669, updated on 3-Jun-2018

    Summary

    Official Symbol
    Mbtps2provided by MGI
    Official Full Name
    membrane-bound transcription factor peptidase, site 2provided by MGI
    Primary source
    MGI:MGI:2444506
    See related
    Ensembl:ENSMUSG00000046873 Vega:OTTMUSG00000019403
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI662535; 9630032G22Rik
    Expression
    Ubiquitous expression in CNS E18 (RPKM 8.9), whole brain E14.5 (RPKM 7.1) and 26 other tissues See more
    Orthologs

    Genomic context

    See Mbtps2 in Genome Data Viewer
    Location:
    X; X F4
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (157547822..157598715, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (153985754..154036647, complement)

    Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene mitochondrial import receptor subunit TOM5 homolog Neighboring gene DnaJ (Hsp40) homolog, subfamily B, member 9 pseudogene Neighboring gene Yy2 transcription factor Neighboring gene predicted gene 15173 Neighboring gene protein Hikeshi pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Clone Names

    • MGC25655

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    metalloendopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    membrane-bound transcription factor site-2 protease
    Names
    S2P endopeptidase
    endopeptidase S2P
    membrane-bound transcription factor protease, site 2
    site-2 protease
    NP_758511.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172307.3NP_758511.1  membrane-bound transcription factor site-2 protease

      See identical proteins and their annotated locations for NP_758511.1

      Status: VALIDATED

      Source sequence(s)
      AK164486, BB556642, BY322697
      Consensus CDS
      CCDS30498.1
      UniProtKB/Swiss-Prot
      Q8CHX6
      Related
      ENSMUSP00000059471.8, OTTMUSP00000020911, ENSMUST00000058098.14, OTTMUST00000046301
      Conserved Domains (3) summary
      cd05709
      Location:415504
      S2P-M50; Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic ...
      cd06162
      Location:14225
      S2P-M50_PDZ_SREBP; Sterol regulatory element-binding protein (SREBP) Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50A), regulates intramembrane proteolysis (RIP) of SREBP and is part of a signal transduction mechanism involved in sterol and lipid ...
      cl00117
      Location:251295
      PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

      Range
      157547822..157598715 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_178266.3: Suppressed sequence

      Description
      NM_178266.3: This RefSeq was permanently suppressed because it contains the wrong CDS.
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