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    Taf1 TATA-box binding protein associated factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 270627, updated on 5-Sep-2021

    Summary

    Official Symbol
    Taf1provided by MGI
    Official Full Name
    TATA-box binding protein associated factor 1provided by MGI
    Primary source
    MGI:MGI:1336878
    See related
    Ensembl:ENSMUSG00000031314
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    KAT; Taf; Ccg1; KAT4; p250; Ccg-1; Taf2a; N-TAF1; AU015687; TAFII250; B430306D02Rik
    Expression
    Broad expression in CNS E11.5 (RPKM 8.6), CNS E14 (RPKM 5.7) and 22 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Taf1 in Genome Data Viewer
    Location:
    X D; X 44.29 cM
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (100576335..100645395)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (101527572..101601789)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (98728074..98797128)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene anaphase promoting complex subunit 13 pseudogene Neighboring gene ring finger protein 26 pseudogene Neighboring gene O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) Neighboring gene RNA binding protein pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to H3K27me3 modified histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase I general transcription initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II core promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II general transcription initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables RNA polymerase II general transcription initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables TBP-class protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables TBP-class protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables lysine-acetylated histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nuclear receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables p53 binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables promoter-specific chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription regulator inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin conjugating enzyme activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in DNA-templated transcription, initiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in RNA polymerase II preinitiation complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in histone acetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of MLL1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in pronucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of transcription factor TFIID complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of transcription factor TFIID complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    transcription initiation factor TFIID subunit 1
    Names
    TBP-associated factor 250 kDa
    cell cycle gene 1 protein
    cell cycle, G1 phase defect
    transcription initiation factor TFIID 250 kDa subunit
    NP_001277658.1
    XP_006528113.1
    XP_006528114.1
    XP_006528115.1
    XP_017174001.1
    XP_017174002.1
    XP_017174004.1
    XP_017174005.1
    XP_017174007.1
    XP_036017865.1
    XP_036017866.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290729.1NP_001277658.1  transcription initiation factor TFIID subunit 1

      See identical proteins and their annotated locations for NP_001277658.1

      Status: VALIDATED

      Source sequence(s)
      AA124343, AB299229, AI510371, AK078319, AK132088, AL831722
      Consensus CDS
      CCDS85793.1
      UniProtKB/Swiss-Prot
      Q80UV9
      UniProtKB/TrEMBL
      B1Q2W7
      Related
      ENSMUSP00000114765.3, ENSMUST00000149274.9
      Conserved Domains (5) summary
      cd05511
      Location:15281640
      Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...
      pfam09247
      Location:3386
      TBP-binding; TATA box-binding protein binding
      pfam12157
      Location:5861048
      DUF3591; Protein of unknown function (DUF3591)
      pfam14797
      Location:17421833
      SEEEED; Serine-rich region of AP3B1, clathrin-adaptor complex
      pfam15288
      Location:12821317
      zf-CCHC_6; Zinc knuckle

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      100576335..100645395
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161973.1XP_036017866.1  transcription initiation factor TFIID subunit 1 isoform X9

      Conserved Domains (4) summary
      cd05511
      Location:15331645
      Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...
      pfam09247
      Location:2886
      TBP-binding; TATA box-binding protein binding
      pfam12157
      Location:5911054
      DUF3591; Protein of unknown function (DUF3591)
      pfam15288
      Location:12871322
      zf-CCHC_6; Zinc knuckle
    2. XM_017318518.3XP_017174007.1  transcription initiation factor TFIID subunit 1 isoform X10

      Conserved Domains (5) summary
      cd05511
      Location:14111522
      Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...
      pfam09247
      Location:2886
      TBP-binding; TATA box-binding protein binding
      pfam12157
      Location:5911054
      DUF3591; Protein of unknown function (DUF3591)
      pfam15288
      Location:12871322
      zf-CCHC_6; Zinc knuckle
      cl02556
      Location:15331612
      Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
    3. XM_017318512.2XP_017174001.1  transcription initiation factor TFIID subunit 1 isoform X1

      Conserved Domains (4) summary
      cd05511
      Location:15331645
      Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...
      pfam09247
      Location:2886
      TBP-binding; TATA box-binding protein binding
      pfam12157
      Location:5911054
      DUF3591; Protein of unknown function (DUF3591)
      pfam15288
      Location:12871322
      zf-CCHC_6; Zinc knuckle
    4. XM_017318515.3XP_017174004.1  transcription initiation factor TFIID subunit 1 isoform X6

      Conserved Domains (4) summary
      cd05511
      Location:15331645
      Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...
      pfam09247
      Location:2886
      TBP-binding; TATA box-binding protein binding
      pfam12157
      Location:5911054
      DUF3591; Protein of unknown function (DUF3591)
      pfam15288
      Location:12871322
      zf-CCHC_6; Zinc knuckle
    5. XM_017318513.3XP_017174002.1  transcription initiation factor TFIID subunit 1 isoform X2

      Conserved Domains (4) summary
      cd05511
      Location:15331645
      Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...
      pfam09247
      Location:2886
      TBP-binding; TATA box-binding protein binding
      pfam12157
      Location:5911054
      DUF3591; Protein of unknown function (DUF3591)
      pfam15288
      Location:12871322
      zf-CCHC_6; Zinc knuckle
    6. XM_017318516.3XP_017174005.1  transcription initiation factor TFIID subunit 1 isoform X7

      Conserved Domains (4) summary
      cd05511
      Location:15331645
      Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...
      pfam09247
      Location:2886
      TBP-binding; TATA box-binding protein binding
      pfam12157
      Location:5911054
      DUF3591; Protein of unknown function (DUF3591)
      pfam15288
      Location:12871322
      zf-CCHC_6; Zinc knuckle
    7. XM_006528050.5XP_006528113.1  transcription initiation factor TFIID subunit 1 isoform X3

      See identical proteins and their annotated locations for XP_006528113.1

      UniProtKB/Swiss-Prot
      Q80UV9
      Related
      ENSMUSP00000138159.2, ENSMUST00000143908.8
      Conserved Domains (4) summary
      cd05511
      Location:15281640
      Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...
      pfam09247
      Location:2886
      TBP-binding; TATA box-binding protein binding
      pfam12157
      Location:5861049
      DUF3591; Protein of unknown function (DUF3591)
      pfam15288
      Location:12821317
      zf-CCHC_6; Zinc knuckle
    8. XM_006528051.4XP_006528114.1  transcription initiation factor TFIID subunit 1 isoform X4

      Conserved Domains (4) summary
      cd05511
      Location:15071619
      Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...
      pfam09247
      Location:2886
      TBP-binding; TATA box-binding protein binding
      pfam12157
      Location:5651028
      DUF3591; Protein of unknown function (DUF3591)
      pfam15288
      Location:12611296
      zf-CCHC_6; Zinc knuckle
    9. XM_006528052.5XP_006528115.1  transcription initiation factor TFIID subunit 1 isoform X5

      UniProtKB/Swiss-Prot
      Q80UV9
      Related
      ENSMUSP00000112772.2, ENSMUST00000118878.8
      Conserved Domains (4) summary
      cd05511
      Location:15071619
      Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...
      pfam09247
      Location:2886
      TBP-binding; TATA box-binding protein binding
      pfam12157
      Location:5651028
      DUF3591; Protein of unknown function (DUF3591)
      pfam15288
      Location:12611296
      zf-CCHC_6; Zinc knuckle
    10. XM_036161972.1XP_036017865.1  transcription initiation factor TFIID subunit 1 isoform X8

      Conserved Domains (4) summary
      cd05511
      Location:15281640
      Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...
      pfam09247
      Location:2886
      TBP-binding; TATA box-binding protein binding
      pfam12157
      Location:5861049
      DUF3591; Protein of unknown function (DUF3591)
      pfam15288
      Location:12821317
      zf-CCHC_6; Zinc knuckle

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001081008.1: Suppressed sequence

      Description
      NM_001081008.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Support Center