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    Taf1 TATA-box binding protein associated factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 270627, updated on 2-Oct-2018

    Summary

    Official Symbol
    Taf1provided by MGI
    Official Full Name
    TATA-box binding protein associated factor 1provided by MGI
    Primary source
    MGI:MGI:1336878
    See related
    Ensembl:ENSMUSG00000031314 Vega:OTTMUSG00000018200
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ccg1; KAT4; p250; Ccg-1; Taf2a; N-TAF1; AU015687; TAFII250; B430306D02Rik
    Expression
    Broad expression in CNS E11.5 (RPKM 8.6), CNS E14 (RPKM 5.7) and 22 other tissues See more
    Orthologs

    Genomic context

    See Taf1 in Genome Data Viewer
    Location:
    X D; X 44.29 cM
    Exon count:
    43
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (101527572..101601789)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (98728074..98797128)

    Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene anaphase promoting complex subunit 13 pseudogene Neighboring gene ring finger protein 26 pseudogene Neighboring gene O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) Neighboring gene RNA binding protein pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to H3K27me3 modified histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II core promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II sequence-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    TBP-class protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    TBP-class protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    histone acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    histone acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    lysine-acetylated histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    p53 binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity, transferring acyl groups IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin conjugating enzyme activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    DNA-templated transcription, initiation IEA
    Inferred from Electronic Annotation
    more info
     
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to ATP ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to UV ISO
    Inferred from Sequence Orthology
    more info
     
    histone acetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    midbrain development ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of androgen receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase I ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    MLL1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    pronucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor TFIID complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription factor TFIID complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    transcription factor complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    transcription initiation factor TFIID subunit 1
    Names
    TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, neuron specific isoform
    TBP-associated factor 250 kDa
    cell cycle gene 1 protein
    cell cycle, G1 phase defect
    transcription initiation factor TFIID 250 kDa subunit
    NP_001277658.1
    XP_006528113.1
    XP_006528114.1
    XP_006528115.1
    XP_006528116.1
    XP_017174001.1
    XP_017174002.1
    XP_017174003.1
    XP_017174004.1
    XP_017174005.1
    XP_017174006.1
    XP_017174007.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290729.1NP_001277658.1  transcription initiation factor TFIID subunit 1

      See identical proteins and their annotated locations for NP_001277658.1

      Status: VALIDATED

      Source sequence(s)
      AA124343, AB299229, AI510371, AK078319, AK132088, AL831722
      Consensus CDS
      CCDS85793.1
      UniProtKB/Swiss-Prot
      Q80UV9
      UniProtKB/TrEMBL
      B1Q2W7
      Related
      ENSMUSP00000114765.2, OTTMUSP00000024423, ENSMUST00000149274.8, OTTMUST00000051768
      Conserved Domains (5) summary
      cd05511
      Location:15281640
      Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...
      pfam09247
      Location:3386
      TBP-binding; TATA box-binding protein binding
      pfam12157
      Location:5861048
      DUF3591; Protein of unknown function (DUF3591)
      pfam14797
      Location:17421833
      SEEEED; Serine-rich region of AP3B1, clathrin-adaptor complex
      pfam15288
      Location:12821317
      zf-CCHC_6; Zinc knuckle

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

      Range
      101527572..101601789
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017318514.1XP_017174003.1  transcription initiation factor TFIID subunit 1 isoform X4

    2. XM_017318518.1XP_017174007.1  transcription initiation factor TFIID subunit 1 isoform X11

    3. XM_017318512.1XP_017174001.1  transcription initiation factor TFIID subunit 1 isoform X1

    4. XM_017318513.1XP_017174002.1  transcription initiation factor TFIID subunit 1 isoform X2

    5. XM_017318516.1XP_017174005.1  transcription initiation factor TFIID subunit 1 isoform X8

    6. XM_006528050.3XP_006528113.1  transcription initiation factor TFIID subunit 1 isoform X3

      See identical proteins and their annotated locations for XP_006528113.1

      UniProtKB/Swiss-Prot
      Q80UV9
      Related
      ENSMUSP00000138159.1, OTTMUSP00000063956, ENSMUST00000143908.7, OTTMUST00000043936
      Conserved Domains (5) summary
      cd05511
      Location:15281640
      Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...
      pfam09247
      Location:3386
      TBP-binding; TATA box-binding protein binding
      pfam12157
      Location:5861048
      DUF3591; Protein of unknown function (DUF3591)
      pfam14797
      Location:17401831
      SEEEED; Serine-rich region of AP3B1, clathrin-adaptor complex
      pfam15288
      Location:12821317
      zf-CCHC_6; Zinc knuckle
    7. XM_006528051.3XP_006528114.1  transcription initiation factor TFIID subunit 1 isoform X5

      Conserved Domains (5) summary
      cd05511
      Location:15071619
      Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...
      pfam09247
      Location:3386
      TBP-binding; TATA box-binding protein binding
      pfam12157
      Location:5651027
      DUF3591; Protein of unknown function (DUF3591)
      pfam14797
      Location:17211812
      SEEEED; Serine-rich region of AP3B1, clathrin-adaptor complex
      pfam15288
      Location:12611296
      zf-CCHC_6; Zinc knuckle
    8. XM_006528052.3XP_006528115.1  transcription initiation factor TFIID subunit 1 isoform X6

      UniProtKB/Swiss-Prot
      Q80UV9
      Related
      ENSMUSP00000112772.1, OTTMUSP00000019728, ENSMUST00000118878.7, OTTMUST00000043935
      Conserved Domains (5) summary
      cd05511
      Location:15071619
      Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...
      pfam09247
      Location:3386
      TBP-binding; TATA box-binding protein binding
      pfam12157
      Location:5651027
      DUF3591; Protein of unknown function (DUF3591)
      pfam14797
      Location:17191810
      SEEEED; Serine-rich region of AP3B1, clathrin-adaptor complex
      pfam15288
      Location:12611296
      zf-CCHC_6; Zinc knuckle
    9. XM_017318515.1XP_017174004.1  transcription initiation factor TFIID subunit 1 isoform X7

    10. XM_006528053.3XP_006528116.1  transcription initiation factor TFIID subunit 1 isoform X9

      Conserved Domains (5) summary
      cd05511
      Location:15281640
      Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...
      pfam09247
      Location:3386
      TBP-binding; TATA box-binding protein binding
      pfam12157
      Location:5861048
      DUF3591; Protein of unknown function (DUF3591)
      pfam14797
      Location:17421833
      SEEEED; Serine-rich region of AP3B1, clathrin-adaptor complex
      pfam15288
      Location:12821317
      zf-CCHC_6; Zinc knuckle
    11. XM_017318517.1XP_017174006.1  transcription initiation factor TFIID subunit 1 isoform X10

    RNA

    1. XR_001782748.1 RNA Sequence

    2. XR_001782749.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001081008.1: Suppressed sequence

      Description
      NM_001081008.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Support Center