Bcap31 B cell receptor associated protein 31 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bcap31provided by MGI
Official Full Name: B cell receptor associated protein 31provided by MGI
Primary source: MGI:MGI:1350933
See related: Ensembl:ENSMUSG00000002015 AllianceGenome:MGI:1350933
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bap31
Summary: Enables MHC class I protein binding activity. Acts upstream of or within several processes, including endoplasmic reticulum to Golgi vesicle-mediated transport; protein localization to endoplasmic reticulum exit site; and spermatogenesis. Located in Golgi membrane and plasma membrane. Is expressed in embryo. Human ortholog(s) of this gene implicated in deafness, dystonia, and cerebral hypomyelination and sensorineural hearing loss. Orthologous to human BCAP31 (B cell receptor associated protein 31). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in placenta adult (RPKM 68.6), subcutaneous fat pad adult (RPKM 42.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: X A7.3; X 37.38 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2023_04	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (72729784..72761421, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (73686178..73717815, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

B-cell receptor associated protein 31 deficiency decreases the expression of adhesion molecule CD11b/CD18 and PSGL-1 in neutrophils to ameliorate acute lung injury.
Title: B-cell receptor associated protein 31 deficiency decreases the expression of adhesion molecule CD11b/CD18 and PSGL-1 in neutrophils to ameliorate acute lung injury.
BAP31 Knockout in Macrophages Affects CD4[+]T Cell Activation through Upregulation of MHC Class II Molecule.
Title: BAP31 Knockout in Macrophages Affects CD4(+)T Cell Activation through Upregulation of MHC Class II Molecule.
BAP31 depletion inhibited adipogenesis, repressed lipolysis and promoted lipid droplets abnormal growth via attenuating Perilipin1 proteasomal degradation.
Title: BAP31 depletion inhibited adipogenesis, repressed lipolysis and promoted lipid droplets abnormal growth via attenuating Perilipin1 proteasomal degradation.
BAP31 regulates the expression of ICAM-1/VCAM-1 via MyD88/NF-kappaB pathway in acute lung injury mice model.
Title: BAP31 regulates the expression of ICAM-1/VCAM-1 via MyD88/NF-κB pathway in acute lung injury mice model.
BCR-Associated Protein 31 Regulates Macrophages Polarization and Wound Healing Function via Early Growth Response 2/C/EBPbeta and IL-4Ralpha/C/EBPbeta Pathways.
Title: BCR-Associated Protein 31 Regulates Macrophages Polarization and Wound Healing Function via Early Growth Response 2/C/EBPβ and IL-4Rα/C/EBPβ Pathways.
These findings indicate that BAP31 may modulate inflammatory cytokines and cognitive impairment induced by neuroinflammation through IRAK1
Title: BAP31 regulates IRAK1-dependent neuroinflammation in microglia.
It findings demonstrate that BAP31-deletion induces SREBP activation and promotes hepatic lipid accumulation, reduces insulin signaling, impairs glucose/insulin tolerance, and increases ER stress and hepatic inflammation, explaining the protective roles of BAP31 in the development of liver steatosis and insulin resistance in HFD-induced obesity in animal models.
Title: Hepatocyte-specific deletion of BAP31 promotes SREBP1C activation, promotes hepatic lipid accumulation, and worsens IR in mice.
Both the mRNA and protein levels of Valosin-Containing Protein were regulated by Bap31 in vivo and in vitro.
Title: B-Cell Receptor-Associated Protein 31 Regulates the Expression of Valosin-Containing Protein Through Elf2.
these results demonstrate that BAP31 may play an important role in T cell activation by regulating TCR signaling.
Title: BAP31 is involved in T cell activation through TCR signal pathways.
The C-terminal domain of BAP31 is exposed on the cell surface of mouse embryonic stem cells.
Title: Epitope Mapping of Antibodies Suggests the Novel Membrane Topology of B-Cell Receptor Associated Protein 31 on the Cell Surface of Embryonic Stem Cells: The Novel Membrane Topology of BAP31.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH128478 (e-PCR)
- UniSTS:211786

R75563 (e-PCR)
- UniSTS:125555

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables MHC class I protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in calcium-mediated signaling using intracellular calcium source	ISO Inferred from Sequence Orthology more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within endoplasmic reticulum to Golgi vesicle-mediated transport	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within endoplasmic reticulum to Golgi vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within immune response	IPI Inferred from Physical Interaction more info	PubMed
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of endoplasmic reticulum calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ER-associated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of retrograde protein transport, ER to cytosol	ISO Inferred from Sequence Orthology more info
involved_in protein localization to endoplasmic reticulum exit site	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein localization to endoplasmic reticulum exit site	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein targeting to mitochondrion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi cisterna membrane	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IDA Inferred from Direct Assay more info	PubMed
located_in clathrin-coated vesicle	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IGI Inferred from Genetic Interaction more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in lipid droplet	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondria-associated endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in perinuclear endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IPI Inferred from Physical Interaction more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: B-cell receptor-associated protein 31

Names: BCR-associated protein 31; accessory protein BAP31; p28

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001313698.1 → NP_001300627.1 B-cell receptor-associated protein 31

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.

Source sequence(s)

AI838720, AK011500, AL805924, CX226458

Consensus CDS

CCDS30209.1

UniProtKB/Swiss-Prot

A2ALM8, Q61335, Q9D0E9, Q9D8G7

UniProtKB/TrEMBL

Q3U9U5

Conserved Domains (3) summary

PRK02224
Location:134 → 237

PRK02224; DNA double-strand break repair Rad50 ATPase

pfam05529
Location:1 → 136

Bap31; B-cell receptor-associated protein 31-like

pfam18035
Location:192 → 245

Bap31_Bap29_C; Bap31/Bap29 cytoplasmic coiled-coil domain
NM_012060.5 → NP_036190.2 B-cell receptor-associated protein 31

See identical proteins and their annotated locations for NP_036190.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the predominant transcript. Variants 1 and 2 both encode the same protein.

Source sequence(s)

AI838720, AK011500, AL805924, CB954946

Consensus CDS

CCDS30209.1

UniProtKB/Swiss-Prot

A2ALM8, Q61335, Q9D0E9, Q9D8G7

UniProtKB/TrEMBL

Q3U9U5

Related

ENSMUSP00000002091.6, ENSMUST00000002091.6

Conserved Domains (3) summary

PRK02224
Location:134 → 237

PRK02224; DNA double-strand break repair Rad50 ATPase

pfam05529
Location:1 → 136

Bap31; B-cell receptor-associated protein 31-like

pfam18035
Location:192 → 245

Bap31_Bap29_C; Bap31/Bap29 cytoplasmic coiled-coil domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2023_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

72729784..72761421 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011247600.4 → XP_011245902.1 B-cell receptor-associated protein 31 isoform X1

See identical proteins and their annotated locations for XP_011245902.1

UniProtKB/Swiss-Prot

A2ALM8, Q61335, Q9D0E9, Q9D8G7

UniProtKB/TrEMBL

Q3U9U5

Conserved Domains (3) summary

PRK02224
Location:134 → 237

PRK02224; DNA double-strand break repair Rad50 ATPase

pfam05529
Location:1 → 136

Bap31; B-cell receptor-associated protein 31-like

pfam18035
Location:192 → 245

Bap31_Bap29_C; Bap31/Bap29 cytoplasmic coiled-coil domain
XM_006528048.4 → XP_006528111.1 B-cell receptor-associated protein 31 isoform X1

See identical proteins and their annotated locations for XP_006528111.1

UniProtKB/Swiss-Prot

A2ALM8, Q61335, Q9D0E9, Q9D8G7

UniProtKB/TrEMBL

Q3U9U5

Conserved Domains (3) summary

PRK02224
Location:134 → 237

PRK02224; DNA double-strand break repair Rad50 ATPase

pfam05529
Location:1 → 136

Bap31; B-cell receptor-associated protein 31-like

pfam18035
Location:192 → 245

Bap31_Bap29_C; Bap31/Bap29 cytoplasmic coiled-coil domain