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    Ncoa4 nuclear receptor coactivator 4 [ Mus musculus (house mouse) ]

    Gene ID: 27057, updated on 11-Jul-2021

    Summary

    Official Symbol
    Ncoa4provided by MGI
    Official Full Name
    nuclear receptor coactivator 4provided by MGI
    Primary source
    MGI:MGI:1350932
    See related
    Ensembl:ENSMUSG00000056234
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rfg; ARA70
    Expression
    Broad expression in liver E14 (RPKM 63.2), liver E14.5 (RPKM 56.4) and 26 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Ncoa4 in Genome Data Viewer
    Location:
    14; 14 B
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (31881836..31901812)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (32159879..32179855)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (32973078..32992549)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41127 Neighboring gene beta-microseminoprotein Neighboring gene eukaryotic translation initiation factor 5 pseudogene Neighboring gene translocase of inner mitochondrial membrane 23 Neighboring gene predicted gene, 23946 Neighboring gene poly (ADP-ribose) glycohydrolase Neighboring gene tetratricopeptide repeat domain 35 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC103382, 1110034E15Rik, 4432406M01Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular iron ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein targeting to lysosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in response to hormone IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in autolysosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in mitochondrion HDA PubMed 

    General protein information

    Preferred Names
    nuclear receptor coactivator 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033988.2NP_001029160.1  nuclear receptor coactivator 4 isoform a

      See identical proteins and their annotated locations for NP_001029160.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longest transcript and encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AC154532, AK143965, AK146498, BB750616, CJ088075
      Consensus CDS
      CCDS36863.1
      UniProtKB/TrEMBL
      Q5U4H9
      Related
      ENSMUSP00000126071.2, ENSMUST00000163336.8
      Conserved Domains (1) summary
      pfam12489
      Location:231326
      ARA70; Nuclear coactivator
    2. NM_001284319.1NP_001271248.1  nuclear receptor coactivator 4 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 2. The encoded isoform (b) has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AC154532, AK014479, AK032951, AK143965, BB750616
      UniProtKB/TrEMBL
      Q8BSH1, Q9CXF3
      Conserved Domains (1) summary
      pfam12489
      Location:136231
      ARA70; Nuclear coactivator
    3. NM_019744.4NP_062718.2  nuclear receptor coactivator 4 isoform a

      See identical proteins and their annotated locations for NP_062718.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 2. Both variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AC154532, AK014479, AK032951, AK143965, BB750616
      Consensus CDS
      CCDS36863.1
      UniProtKB/TrEMBL
      Q5U4H9, Q8BSH1, Q9CXF3
      Related
      ENSMUSP00000107625.4, ENSMUST00000111994.10
      Conserved Domains (1) summary
      pfam12489
      Location:231326
      ARA70; Nuclear coactivator

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      31881836..31901812
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316028.2XP_017171517.1  nuclear receptor coactivator 4 isoform X3

      Conserved Domains (1) summary
      pfam12489
      Location:230325
      ARA70; Nuclear coactivator
    2. XM_006519068.5XP_006519131.1  nuclear receptor coactivator 4 isoform X2

      Conserved Domains (1) summary
      pfam12489
      Location:238333
      ARA70; Nuclear coactivator
    3. XM_006519067.4XP_006519130.1  nuclear receptor coactivator 4 isoform X1

      Conserved Domains (1) summary
      pfam12489
      Location:239334
      ARA70; Nuclear coactivator
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