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    SND1 staphylococcal nuclease and tudor domain containing 1 [ Homo sapiens (human) ]

    Gene ID: 27044, updated on 17-Jan-2022

    Summary

    Official Symbol
    SND1provided by HGNC
    Official Full Name
    staphylococcal nuclease and tudor domain containing 1provided by HGNC
    Primary source
    HGNC:HGNC:30646
    See related
    Ensembl:ENSG00000197157 MIM:602181
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p100; TDRD11; Tudor-SN
    Summary
    This gene encodes a transcriptional co-activator that interacts with the acidic domain of Epstein-Barr virus nuclear antigen 2 (EBNA 2), a transcriptional activator that is required for B-lymphocyte transformation. Other transcription factors that interact with this protein are signal transducers and activators of transcription, STATs. This protein is also thought to be essential for normal cell growth. A similar protein in mammals and other organisms is a component of the RNA-induced silencing complex (RISC). [provided by RefSeq, Jul 2016]
    Expression
    Ubiquitous expression in placenta (RPKM 45.9), thyroid (RPKM 41.6) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See SND1 in Genome Data Viewer
    Location:
    7q32.1
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (127652145..128092593)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (127292248..127732645)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene PAX4 5' regulatory region Neighboring gene fascin actin-bundling protein 3 Neighboring gene paired box 4 Neighboring gene CD2 cytoplasmic tail binding protein 2 pseudogene Neighboring gene uncharacterized LOC105375492 Neighboring gene SND1 intronic transcript 1 Neighboring gene leucine rich repeat containing 4 Neighboring gene uncharacterized LOC105375493 Neighboring gene microRNA 593 Neighboring gene microRNA 129-1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study in a Chinese population identifies a susceptibility locus for type 2 diabetes at 7q32 near PAX4.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Interaction of HIV-1 Gag with staphylococcal nuclease and tudor domain containing 1 (SND1) is identified in a series of six affinity purification/mass spectrometry screens PubMed
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human staphylococcal nuclease and tudor domain containing 1 (SND1) at amino acid residues 670-671 by the HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RISC complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA binding HDA PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cadherin binding HDA PubMed 
    enables endonuclease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables endoribonuclease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coregulator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of RISC complex IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in dense body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in melanosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    staphylococcal nuclease domain-containing protein 1
    Names
    EBNA2 coactivator p100
    testis tissue sperm-binding protein Li 82P
    tudor domain-containing protein 11
    NP_055205.2
    XP_016867476.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051199.1 RefSeqGene

      Range
      5206..445605
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_014390.4NP_055205.2  staphylococcal nuclease domain-containing protein 1

      See identical proteins and their annotated locations for NP_055205.2

      Status: REVIEWED

      Source sequence(s)
      BC017180, BE799345, BQ217773
      Consensus CDS
      CCDS34747.1
      UniProtKB/Swiss-Prot
      Q7KZF4
      UniProtKB/TrEMBL
      A0A140VK49
      Related
      ENSP00000346762.3, ENST00000354725.8
      Conserved Domains (5) summary
      smart00333
      Location:728784
      TUDOR; Tudor domain
      smart00318
      Location:21166
      SNc; Staphylococcal nuclease homologues
      cd00175
      Location:26166
      SNc; Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds.
      pfam00567
      Location:677799
      TUDOR; Tudor domain
      cl00140
      Location:844895
      SNc; Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds.

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

      Range
      127652145..128092593
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017011987.2XP_016867476.1  staphylococcal nuclease domain-containing protein 1 isoform X1

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