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    G3bp1 GTPase activating protein (SH3 domain) binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 27041, updated on 6-Sep-2021

    Summary

    Official Symbol
    G3bp1provided by MGI
    Official Full Name
    GTPase activating protein (SH3 domain) binding protein 1provided by MGI
    Primary source
    MGI:MGI:1351465
    See related
    Ensembl:ENSMUSG00000018583
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    G3bp; C87777; AI849976; mKIAA4115; B430204O07
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 53.7), limb E14.5 (RPKM 33.9) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See G3bp1 in Genome Data Viewer
    Location:
    11; 11 B1.3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (55360486..55391714)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (55469657..55500888)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (55283254..55314389)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene antioxidant 1 copper chaperone Neighboring gene predicted gene 12235 Neighboring gene predicted gene 12238 Neighboring gene microRNA 7652 Neighboring gene predicted gene 12236 Neighboring gene glycine receptor, alpha 1 subunit

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA4115

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA/RNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    ras GTPase-activating protein-binding protein 1
    Names
    ATP-dependent DNA helicase VIII
    G3BP-1
    GAP SH3 binding protein
    GAP SH3 domain-binding protein 1
    HDH-VIII
    Ras-GTPase-activating protein SH3-domain binding protein 1
    NP_038744.1
    XP_030101902.1
    XP_030101903.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013716.2NP_038744.1  ras GTPase-activating protein-binding protein 1

      See identical proteins and their annotated locations for NP_038744.1

      Status: PROVISIONAL

      Source sequence(s)
      AL596207
      Consensus CDS
      CCDS24714.1
      UniProtKB/Swiss-Prot
      P97855
      Related
      ENSMUSP00000018727.4, ENSMUST00000018727.4
      Conserved Domains (4) summary
      PRK13733
      Location:210310
      PRK13733; conjugal transfer protein TraV; Provisional
      COG0724
      Location:266418
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd00780
      Location:7135
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
      cd12463
      Location:335414
      RRM_G3BP1; RNA recognition motif found in ras GTPase-activating protein-binding protein 1 (G3BP1) and similar proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      55360486..55391714
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246042.2XP_030101902.1  ras GTPase-activating protein-binding protein 1 isoform X1

      Conserved Domains (3) summary
      PRK14950
      Location:150261
      PRK14950; DNA polymerase III subunits gamma and tau; Provisional
      cd00780
      Location:170
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
      cl17169
      Location:270349
      RRM_SF; RNA recognition motif (RRM) superfamily
    2. XM_030246043.2XP_030101903.1  ras GTPase-activating protein-binding protein 1 isoform X1

      Conserved Domains (3) summary
      PRK14950
      Location:150261
      PRK14950; DNA polymerase III subunits gamma and tau; Provisional
      cd00780
      Location:170
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
      cl17169
      Location:270349
      RRM_SF; RNA recognition motif (RRM) superfamily
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