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    NOX1 NADPH oxidase 1 [ Homo sapiens (human) ]

    Gene ID: 27035, updated on 6-Jun-2024

    Summary

    Official Symbol
    NOX1provided by HGNC
    Official Full Name
    NADPH oxidase 1provided by HGNC
    Primary source
    HGNC:HGNC:7889
    See related
    Ensembl:ENSG00000007952 MIM:300225; AllianceGenome:HGNC:7889
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MOX1; NOH1; NOH-1; GP91-2; NOH-1L
    Summary
    This gene encodes a member of the NADPH oxidase family of enzymes responsible for the catalytic one-electron transfer of oxygen to generate superoxide or hydrogen peroxide. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]
    Expression
    Restricted expression toward colon (RPKM 30.7) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See NOX1 in Genome Data Viewer
    Location:
    Xq22.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (100843324..100874359, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (99285862..99317015, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (100098313..100129348, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:100059685-100060282 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chrX:100067081-100067582 Neighboring gene RAD21 pseudogene 1 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chrX:100067583-100068082 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29801 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29802 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29803 Neighboring gene small nucleolar RNA SNORA9 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29804 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29805 Neighboring gene cleavage stimulation factor subunit 2 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 26 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 27 Neighboring gene NANOG hESC enhancer GRCh37_chrX:100150382-100150883 Neighboring gene XK related X-linked Neighboring gene NSA2 pseudogene 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 binding to CXCR4 induces NADPH oxidase-mediated production of superoxide radicals in neurons, which is involved in the activation of neutral sphingomyelinase PubMed
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 inhibits the cellular immune response and enhances oxidative stress mediated by NADPH oxidase PubMed
    Envelope transmembrane glycoprotein gp41 env The 3S motif of HIV-1 gp41 stimulates ROS production by NADPH oxidase PubMed
    Nef nef NADPH oxidase is required for HIV-1 Nef-induced ROS production and endothelial apoptosis in human coronary arterial endothelial cells PubMed
    nef HIV-1 Nef-induced blockade of superoxide release is caused by the inhibition of NADPH oxidase activities in human macrophages; this inhibition is regulated by Nef-mediated increased synthesis and release of IL-10 PubMed
    nef Nef induces the phosphorylation and then the translocation of the cytosolic subunit of NADPH oxidase complex p47(phox) to the plasma membrane PubMed
    nef Both Nef membrane localization and intact SH3-binding domain are involved in NADPH oxidase activation and superoxide anion release PubMed
    Tat tat PDGF-BB inhibits NADPH oxidase-mediated reactive oxygen species production induced by HIV-1 Tat and morphine treatment in neuroblastoma cells PubMed
    tat The NADPH oxidase inhibitors DPI and apocynin abrogate HIV-1 Tat-stimulated ERK1/2 activation in human microglia-like cells PubMed
    tat HIV-1 Tat increases CXCL10 expression in IFN-gamma and TNF-alpha stimulated human astrocytes via NADPH oxidase PubMed
    tat Phosphatidylinositol 3-kinase/Akt signaling pathway is involved in HIV-1 Tat-induced NADPH oxidase stimulation and LTR transactivation PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in JNK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in NADP metabolic process IC
    Inferred by Curator
    more info
    PubMed 
    involved_in angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to hyperoxia IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in defense response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in extracellular matrix organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hydrogen peroxide metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in inflammatory response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in oxygen metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of JNK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of integrin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of smooth muscle cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of vascular endothelial growth factor production IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in regulation of blood pressure TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of systemic arterial blood pressure by renin-angiotensin IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in respiratory burst TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in superoxide anion generation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in superoxide anion generation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in superoxide anion generation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of NADPH oxidase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of NADPH oxidase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    NADPH oxidase 1
    Names
    NADH/NADPH mitogenic oxidase subunit P65-MOX
    NADPH oxidase homolog-1
    mitogenic oxidase (pyridine nucleotide-dependent superoxide-generating)
    mitogenic oxidase 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012567.1 RefSeqGene

      Range
      4987..36022
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001271815.2NP_001258744.1  NADPH oxidase 1 isoform 3

      See identical proteins and their annotated locations for NP_001258744.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an in-frame 5' coding exon, compared to variant 1 (NOH-1L). The resulting isoform (3) has the same N- and C-termini but is shorter, compared to isoform 1.
      Source sequence(s)
      AF127763, AF166327, AI285296, AK292201, BX956931, DQ424904, Z83819
      Consensus CDS
      CCDS65298.1
      UniProtKB/TrEMBL
      A6NGA6, Q1ZYL4
      Related
      ENSP00000362051.4, ENST00000372960.8
      Conserved Domains (2) summary
      cd06186
      Location:260527
      NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
      pfam01794
      Location:48176
      Ferric_reduct; Ferric reductase like transmembrane component
    2. NM_007052.5NP_008983.2  NADPH oxidase 1 isoform 1

      See identical proteins and their annotated locations for NP_008983.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, alternately referred to as NOH-1L per PMID: 10615049) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AF127763, AF166327, BX956931, Z83819
      Consensus CDS
      CCDS14474.1
      UniProtKB/Swiss-Prot
      A8K836, O95691, Q2PP02, Q9Y5S8
      UniProtKB/TrEMBL
      Q1ZYL4
      Related
      ENSP00000362057.3, ENST00000372966.8
      Conserved Domains (2) summary
      cd06186
      Location:297564
      NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
      pfam01794
      Location:66213
      Ferric_reduct; Ferric reductase like transmembrane component
    3. NM_013955.3NP_039249.1  NADPH oxidase 1 isoform 2

      See identical proteins and their annotated locations for NP_039249.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, alternately referred to as NOH-1Lv per PMID: 10615049) lacks an alternate in-frame coding exon, compared to variant 1 (NOH-1L). The resulting isoform (2) has the same N- and C-termini but is shorter, compared to isoform 1.
      Source sequence(s)
      AF127763, AF166328, BX956931, Z83819
      Consensus CDS
      CCDS14475.1
      UniProtKB/TrEMBL
      Q8TCT3
      Related
      ENSP00000217885.5, ENST00000217885.5
      Conserved Domains (2) summary
      cd06186
      Location:297515
      NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
      pfam01794
      Location:66213
      Ferric_reduct; Ferric reductase like transmembrane component

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      100843324..100874359 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017029407.3XP_016884896.1  NADPH oxidase 1 isoform X1

      UniProtKB/TrEMBL
      Q1ZYL4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      99285862..99317015 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054326825.1XP_054182800.1  NADPH oxidase 1 isoform X1

      UniProtKB/TrEMBL
      Q1ZYL4

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_013954.1: Suppressed sequence

      Description
      NM_013954.1: This RefSeq was permanently suppressed because the submitters of the transcript data determined that this was not a biologically valid sequence.