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    Klhl18 kelch-like 18 [ Mus musculus (house mouse) ]

    Gene ID: 270201, updated on 23-Jun-2021

    Summary

    Official Symbol
    Klhl18provided by MGI
    Official Full Name
    kelch-like 18provided by MGI
    Primary source
    MGI:MGI:2143315
    See related
    Ensembl:ENSMUSG00000054792
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AW545966; A930041K15
    Expression
    Ubiquitous expression in CNS E18 (RPKM 10.6), whole brain E14.5 (RPKM 7.6) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Klhl18 in Genome Data Viewer
    Location:
    9; 9 F2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (110254994..110305768, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (110425926..110476737, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (110328430..110379198, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase, non-receptor type 23 Neighboring gene neutrophilic granule protein Neighboring gene kinesin family member 9 Neighboring gene SET domain containing 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

    Markers

    Homology

    Clone Names

    • MGC36415

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of mitotic cell cycle phase transition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360306.1NP_001347235.1  kelch-like protein 18 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC132103, AC160104, BC065167
      Consensus CDS
      CCDS90672.1
      Related
      ENSMUSP00000143634.2, ENSMUST00000198164.5
      Conserved Domains (4) summary
      PHA03098
      Location:34557
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:331374
      Kelch; KELCH repeat [structural motif]
      cd18247
      Location:19134
      BTB_POZ_KLHL18; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18)
      cd18457
      Location:135241
      BACK_KLHL18; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18)
    2. NM_177771.5NP_808439.2  kelch-like protein 18 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC132103, BC065167, BY195998, BY248410, CB247282, CF739377, CK619719
      Consensus CDS
      CCDS23567.1
      UniProtKB/TrEMBL
      E9Q4F2
      Related
      ENSMUSP00000069674.7, ENSMUST00000068025.13
      Conserved Domains (4) summary
      PHA03098
      Location:34552
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:326369
      Kelch; KELCH repeat [structural motif]
      cd18247
      Location:19134
      BTB_POZ_KLHL18; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18)
      cd18457
      Location:135241
      BACK_KLHL18; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      110254994..110305768 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244406.2XP_030100266.1  kelch-like protein 18 isoform X2

      Conserved Domains (3) summary
      PHA03098
      Location:3440
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:214257
      Kelch; KELCH repeat [structural motif]
      cd18457
      Location:23129
      BACK_KLHL18; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18)
    2. XM_030244405.2XP_030100265.1  kelch-like protein 18 isoform X1

      Conserved Domains (3) summary
      PHA03098
      Location:3445
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:219262
      Kelch; KELCH repeat [structural motif]
      cd18457
      Location:23129
      BACK_KLHL18; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18)
    3. XM_017313405.3XP_017168894.1  kelch-like protein 18 isoform X3

      Conserved Domains (5) summary
      smart00612
      Location:318370
      Kelch; Kelch domain
      sd00038
      Location:311356
      Kelch; KELCH repeat [structural motif]
      cd18247
      Location:19134
      BTB_POZ_KLHL18; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18)
      cd18457
      Location:135270
      BACK_KLHL18; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18)
      pfam01344
      Location:359404
      Kelch_1; Kelch motif
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