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    Clpx caseinolytic mitochondrial matrix peptidase chaperone subunit [ Mus musculus (house mouse) ]

    Gene ID: 270166, updated on 8-Jul-2021

    Summary

    Official Symbol
    Clpxprovided by MGI
    Official Full Name
    caseinolytic mitochondrial matrix peptidase chaperone subunitprovided by MGI
    Primary source
    MGI:MGI:1346017
    See related
    Ensembl:ENSMUSG00000015357
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AU014732; E330029I21
    Expression
    Ubiquitous expression in liver E18 (RPKM 23.0), testis adult (RPKM 18.8) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Clpx in Genome Data Viewer
    Location:
    9 C; 9 35.22 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (65201533..65237940)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (65294251..65330658)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (65142102..65178465)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene poly (ADP-ribose) polymerase family, member 16 Neighboring gene predicted gene, 36538 Neighboring gene cartilage intermediate layer protein, nucleotide pyrophosphohydrolase Neighboring gene predicted gene 16218 Neighboring gene predicted gene, 19219 Neighboring gene programmed cell death 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to ATP-dependent peptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in ATP metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in proteolysis involved in cellular protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of endopeptidase Clp complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of mitochondrial endopeptidase Clp complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial inner membrane HDA PubMed 
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial nucleoid ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial
    Names
    caseinolytic peptidase X
    caseinolytic protease X

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044389.2NP_001037854.1  ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial isoform 2

      See identical proteins and their annotated locations for NP_001037854.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AC110235, AK087848, AV237409, BC061153
      Consensus CDS
      CCDS40669.1
      UniProtKB/TrEMBL
      Q6P8N8
      Related
      ENSMUSP00000109455.2, ENSMUST00000113824.8
      Conserved Domains (4) summary
      smart01086
      Location:496590
      ClpB_D2-small; C-terminal, D2-small domain, of ClpB protein
      TIGR00382
      Location:103587
      clpX; endopeptidase Clp ATP-binding regulatory subunit (clpX)
      pfam07724
      Location:273489
      AAA_2; AAA domain (Cdc48 subfamily)
      cl02609
      Location:105133
      Zn-ribbon; C-terminal zinc ribbon domain of RNA polymerase intrinsic transcript cleavage subunit
    2. NM_011802.3NP_035932.2  ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_035932.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC110235, AK080339, AK087848, AV237409
      Consensus CDS
      CCDS23288.1
      UniProtKB/Swiss-Prot
      Q9JHS4
      UniProtKB/TrEMBL
      Q8C4Z5
      Related
      ENSMUSP00000015501.5, ENSMUST00000015501.11
      Conserved Domains (4) summary
      smart01086
      Location:510604
      ClpB_D2-small; C-terminal, D2-small domain, of ClpB protein
      TIGR00382
      Location:103601
      clpX; endopeptidase Clp ATP-binding regulatory subunit (clpX)
      pfam07724
      Location:287503
      AAA_2; AAA domain (Cdc48 subfamily)
      cl02609
      Location:105133
      Zn-ribbon; C-terminal zinc ribbon domain of RNA polymerase intrinsic transcript cleavage subunit

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      65201533..65237940
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_379423.4 RNA Sequence

    2. XR_003947922.2 RNA Sequence

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