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    Myo9a myosin IXa [ Mus musculus (house mouse) ]

    Gene ID: 270163, updated on 8-Jul-2021

    Summary

    Official Symbol
    Myo9aprovided by MGI
    Official Full Name
    myosin IXaprovided by MGI
    Primary source
    MGI:MGI:107735
    See related
    Ensembl:ENSMUSG00000039585
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C230003M11; 4732465J09Rik; C130068I12Rik
    Expression
    Broad expression in CNS E18 (RPKM 7.1), whole brain E14.5 (RPKM 5.5) and 21 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Myo9a in Genome Data Viewer
    Location:
    9 B; 9 32.13 cM
    Exon count:
    45
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (59658128..59836149)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (59750848..59928866)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (59598981..59776673)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene GRAM domain containing 2 Neighboring gene transcription factor BTF3-like Neighboring gene SUMO peptidase family member, NEDD8 specific Neighboring gene predicted gene, 20275 Neighboring gene 60S ribosomal protein L37 pseudogene Neighboring gene predicted gene 7616 Neighboring gene nuclear receptor subfamily 2, group E, member 3 Neighboring gene thrombospondin, type I, domain containing 4 Neighboring gene RIKEN cDNA 2010001M07 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cell junction assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of epithelial cell apical/basal polarity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of neuron projection arborization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in axonal growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    unconventional myosin-IXa
    Names
    unconventional myosin-9a

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173018.2NP_766606.2  unconventional myosin-IXa

      Status: VALIDATED

      Source sequence(s)
      AC131749, AC156795, AC160637
      Consensus CDS
      CCDS52820.1
      UniProtKB/TrEMBL
      D3Z3A8
      Related
      ENSMUSP00000122852.2, ENSMUST00000136740.8
      Conserved Domains (5) summary
      smart00015
      Location:11161137
      IQ; Calmodulin-binding motif
      cd04377
      Location:21342319
      RhoGAP_myosin_IX; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class ...
      cd01385
      Location:1601005
      MYSc_Myo9; class IX myosin, motor domain
      cd17216
      Location:15110
      RA_Myosin-IXa; Ras-associating (RA) domain found in Myosin-IXa
      cd20883
      Location:20682125
      C1_Myosin-IXa; protein kinase C conserved region 1 (C1 domain) found in unconventional myosin-IXa and similar proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      59658128..59836149
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155030.1XP_036010923.1  unconventional myosin-IXa isoform X2

      Conserved Domains (5) summary
      smart00015
      Location:11161137
      IQ; Calmodulin-binding motif
      cd04377
      Location:21352320
      RhoGAP_myosin_IX; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class ...
      cd01385
      Location:1601005
      MYSc_Myo9; class IX myosin, motor domain
      cd17216
      Location:15110
      RA_Myosin-IXa; Ras-associating (RA) domain found in Myosin-IXa
      cd20883
      Location:20692126
      C1_Myosin-IXa; protein kinase C conserved region 1 (C1 domain) found in unconventional myosin-IXa and similar proteins
    2. XM_036155031.1XP_036010924.1  unconventional myosin-IXa isoform X4

      Conserved Domains (5) summary
      smart00015
      Location:11161137
      IQ; Calmodulin-binding motif
      cd04377
      Location:21342319
      RhoGAP_myosin_IX; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class ...
      cd01385
      Location:1601005
      MYSc_Myo9; class IX myosin, motor domain
      cd17216
      Location:15110
      RA_Myosin-IXa; Ras-associating (RA) domain found in Myosin-IXa
      cd20883
      Location:20682125
      C1_Myosin-IXa; protein kinase C conserved region 1 (C1 domain) found in unconventional myosin-IXa and similar proteins
    3. XM_006511209.5XP_006511272.1  unconventional myosin-IXa isoform X1

      See identical proteins and their annotated locations for XP_006511272.1

      Conserved Domains (7) summary
      smart00015
      Location:11171138
      IQ; Calmodulin-binding motif
      cd00029
      Location:20752123
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd04377
      Location:21362321
      RhoGAP_myosin_IX; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class ...
      cd01385
      Location:1601006
      MYSc_Myo9; class IX myosin, motor domain
      cd17216
      Location:15110
      RA_Myosin-IXa; Ras-associating (RA) domain found in Myosin-IXa
      pfam15275
      Location:18271891
      PEHE; PEHE domain
      pfam17380
      Location:9681283
      DUF5401; Family of unknown function (DUF5401)
    4. XM_006511210.3XP_006511273.1  unconventional myosin-IXa isoform X2

      Conserved Domains (5) summary
      smart00015
      Location:11161137
      IQ; Calmodulin-binding motif
      cd04377
      Location:21352320
      RhoGAP_myosin_IX; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class ...
      cd01385
      Location:1601005
      MYSc_Myo9; class IX myosin, motor domain
      cd17216
      Location:15110
      RA_Myosin-IXa; Ras-associating (RA) domain found in Myosin-IXa
      cd20883
      Location:20692126
      C1_Myosin-IXa; protein kinase C conserved region 1 (C1 domain) found in unconventional myosin-IXa and similar proteins
    5. XM_017313399.2XP_017168888.1  unconventional myosin-IXa isoform X11

      Conserved Domains (7) summary
      smart00015
      Location:11161137
      IQ; Calmodulin-binding motif
      cd00029
      Location:20022050
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd04377
      Location:20632248
      RhoGAP_myosin_IX; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class ...
      cd01385
      Location:1601005
      MYSc_Myo9; class IX myosin, motor domain
      cd17216
      Location:15110
      RA_Myosin-IXa; Ras-associating (RA) domain found in Myosin-IXa
      pfam15275
      Location:17541818
      PEHE; PEHE domain
      pfam17380
      Location:9671282
      DUF5401; Family of unknown function (DUF5401)
    6. XM_006511220.3XP_006511283.1  unconventional myosin-IXa isoform X14

      See identical proteins and their annotated locations for XP_006511283.1

      UniProtKB/Swiss-Prot
      Q8C170
      Related
      ENSMUSP00000119401.2, ENSMUST00000128341.2
      Conserved Domains (7) summary
      smart00015
      Location:11161137
      IQ; Calmodulin-binding motif
      cd00029
      Location:20022050
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd04377
      Location:20632248
      RhoGAP_myosin_IX; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class ...
      cd01385
      Location:1601005
      MYSc_Myo9; class IX myosin, motor domain
      cd17216
      Location:15110
      RA_Myosin-IXa; Ras-associating (RA) domain found in Myosin-IXa
      pfam15275
      Location:17541818
      PEHE; PEHE domain
      pfam17380
      Location:9671282
      DUF5401; Family of unknown function (DUF5401)
    7. XM_036155033.1XP_036010926.1  unconventional myosin-IXa isoform X9

      Conserved Domains (5) summary
      smart00015
      Location:10971118
      IQ; Calmodulin-binding motif
      cd04377
      Location:21152300
      RhoGAP_myosin_IX; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class ...
      cd01385
      Location:160986
      MYSc_Myo9; class IX myosin, motor domain
      cd17216
      Location:15110
      RA_Myosin-IXa; Ras-associating (RA) domain found in Myosin-IXa
      cd20883
      Location:20492106
      C1_Myosin-IXa; protein kinase C conserved region 1 (C1 domain) found in unconventional myosin-IXa and similar proteins
    8. XM_006511215.4XP_006511278.1  unconventional myosin-IXa isoform X8

      Conserved Domains (7) summary
      smart00015
      Location:10971118
      IQ; Calmodulin-binding motif
      cd00029
      Location:20552103
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd04377
      Location:21162301
      RhoGAP_myosin_IX; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class ...
      cd01385
      Location:160986
      MYSc_Myo9; class IX myosin, motor domain
      cd17216
      Location:15110
      RA_Myosin-IXa; Ras-associating (RA) domain found in Myosin-IXa
      pfam15275
      Location:18071871
      PEHE; PEHE domain
      pfam17380
      Location:9481263
      DUF5401; Family of unknown function (DUF5401)
    9. XM_006511208.4XP_006511271.1  unconventional myosin-IXa isoform X1

      See identical proteins and their annotated locations for XP_006511271.1

      Conserved Domains (7) summary
      smart00015
      Location:11171138
      IQ; Calmodulin-binding motif
      cd00029
      Location:20752123
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd04377
      Location:21362321
      RhoGAP_myosin_IX; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class ...
      cd01385
      Location:1601006
      MYSc_Myo9; class IX myosin, motor domain
      cd17216
      Location:15110
      RA_Myosin-IXa; Ras-associating (RA) domain found in Myosin-IXa
      pfam15275
      Location:18271891
      PEHE; PEHE domain
      pfam17380
      Location:9681283
      DUF5401; Family of unknown function (DUF5401)
    10. XM_006511212.4XP_006511275.1  unconventional myosin-IXa isoform X5

      Conserved Domains (7) summary
      smart00015
      Location:11171138
      IQ; Calmodulin-binding motif
      cd00029
      Location:20752123
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd04377
      Location:21362321
      RhoGAP_myosin_IX; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class ...
      cd01385
      Location:1601006
      MYSc_Myo9; class IX myosin, motor domain
      cd17216
      Location:15110
      RA_Myosin-IXa; Ras-associating (RA) domain found in Myosin-IXa
      pfam15275
      Location:18271891
      PEHE; PEHE domain
      pfam17380
      Location:9681283
      DUF5401; Family of unknown function (DUF5401)
    11. XM_006511211.4XP_006511274.1  unconventional myosin-IXa isoform X3

      Conserved Domains (7) summary
      smart00015
      Location:11171138
      IQ; Calmodulin-binding motif
      cd00029
      Location:20742122
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd04377
      Location:21352320
      RhoGAP_myosin_IX; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class ...
      cd01385
      Location:1601006
      MYSc_Myo9; class IX myosin, motor domain
      cd17216
      Location:15110
      RA_Myosin-IXa; Ras-associating (RA) domain found in Myosin-IXa
      pfam15275
      Location:18261890
      PEHE; PEHE domain
      pfam17380
      Location:9681283
      DUF5401; Family of unknown function (DUF5401)
    12. XM_036155032.1XP_036010925.1  unconventional myosin-IXa isoform X6

      Related
      ENSMUSP00000117432.2, ENSMUST00000135298.8
      Conserved Domains (5) summary
      smart00015
      Location:11171138
      IQ; Calmodulin-binding motif
      cd04377
      Location:21352320
      RhoGAP_myosin_IX; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class ...
      cd01385
      Location:1601006
      MYSc_Myo9; class IX myosin, motor domain
      cd17216
      Location:15110
      RA_Myosin-IXa; Ras-associating (RA) domain found in Myosin-IXa
      cd20883
      Location:20692126
      C1_Myosin-IXa; protein kinase C conserved region 1 (C1 domain) found in unconventional myosin-IXa and similar proteins
    13. XM_006511216.4XP_006511279.1  unconventional myosin-IXa isoform X10

      Conserved Domains (7) summary
      smart00015
      Location:11171138
      IQ; Calmodulin-binding motif
      cd00029
      Location:20032051
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd04377
      Location:20642249
      RhoGAP_myosin_IX; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class ...
      cd01385
      Location:1601006
      MYSc_Myo9; class IX myosin, motor domain
      cd17216
      Location:15110
      RA_Myosin-IXa; Ras-associating (RA) domain found in Myosin-IXa
      pfam15275
      Location:17551819
      PEHE; PEHE domain
      pfam17380
      Location:9681283
      DUF5401; Family of unknown function (DUF5401)
    14. XM_006511217.4XP_006511280.1  unconventional myosin-IXa isoform X12

      Conserved Domains (7) summary
      smart00015
      Location:11171138
      IQ; Calmodulin-binding motif
      cd00029
      Location:20032051
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd04377
      Location:20642249
      RhoGAP_myosin_IX; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class ...
      cd01385
      Location:1601006
      MYSc_Myo9; class IX myosin, motor domain
      cd17216
      Location:15110
      RA_Myosin-IXa; Ras-associating (RA) domain found in Myosin-IXa
      pfam15275
      Location:17551819
      PEHE; PEHE domain
      pfam17380
      Location:9681283
      DUF5401; Family of unknown function (DUF5401)
    15. XM_006511213.4XP_006511276.1  unconventional myosin-IXa isoform X7

      Conserved Domains (7) summary
      smart00015
      Location:10981119
      IQ; Calmodulin-binding motif
      cd00029
      Location:20562104
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd04377
      Location:21172302
      RhoGAP_myosin_IX; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class ...
      cd01385
      Location:160987
      MYSc_Myo9; class IX myosin, motor domain
      cd17216
      Location:15110
      RA_Myosin-IXa; Ras-associating (RA) domain found in Myosin-IXa
      pfam15275
      Location:18081872
      PEHE; PEHE domain
      pfam17380
      Location:9491264
      DUF5401; Family of unknown function (DUF5401)
    16. XM_017313400.3XP_017168889.1  unconventional myosin-IXa isoform X13

      Conserved Domains (4) summary
      smart00015
      Location:11171138
      IQ; Calmodulin-binding motif
      cd01385
      Location:1601006
      MYSc_Myo9; class IX myosin, motor domain
      cd17216
      Location:15110
      RA_Myosin-IXa; Ras-associating (RA) domain found in Myosin-IXa
      pfam17380
      Location:9681283
      DUF5401; Family of unknown function (DUF5401)
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