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    Nup98 nucleoporin 98 [ Mus musculus (house mouse) ]

    Gene ID: 269966, updated on 23-Jun-2021

    Summary

    Official Symbol
    Nup98provided by MGI
    Official Full Name
    nucleoporin 98provided by MGI
    Primary source
    MGI:MGI:109404
    See related
    Ensembl:ENSMUSG00000063550
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nup; Nup96; AI849286; 4732457F17
    Expression
    Broad expression in testis adult (RPKM 45.3), placenta adult (RPKM 7.7) and 27 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Nup98 in Genome Data Viewer
    Location:
    7 E2; 7 54.71 cM
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (101768607..101859375, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (102119400..102210166, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (109282717..109358634, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene ADP-ribosyltransferase 5 Neighboring gene cholinergic receptor, nicotinic, alpha polypeptide 10 Neighboring gene ADP-ribosyltransferase 1 Neighboring gene post-GPI attachment to proteins 2 Neighboring gene ras homolog family member G Neighboring gene stromal interaction molecule 1 Neighboring gene methyltransferase like 6 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC118567

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nuclear localization sequence binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables promoter-specific chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables structural constituent of nuclear pore ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within mRNA transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nuclear pore complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nucleocytoplasmic transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear inclusion body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear periphery ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nuclear pore ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nuclear pore nuclear basket ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nuclear pore outer ring ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    nuclear pore complex protein Nup98-Nup96

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001287164.1NP_001274093.1  nuclear pore complex protein Nup98-Nup96 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001274093.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC118592, AK028800, BC050911, BC078630
      Consensus CDS
      CCDS85358.1
      UniProtKB/Swiss-Prot
      Q6PFD9
      UniProtKB/TrEMBL
      A0A1B0GSX7
      Related
      ENSMUSP00000148115.2, ENSMUST00000210682.2
      Conserved Domains (3) summary
      pfam04096
      Location:740880
      Nucleoporin2; Nucleoporin autopeptidase
      pfam12110
      Location:13331622
      Nup96; Nuclear protein 96
      pfam13634
      Location:40149
      Nucleoporin_FG; Nucleoporin FG repeat region
    2. NM_001287165.1NP_001274094.1  nuclear pore complex protein Nup98-Nup96 isoform 3

      See identical proteins and their annotated locations for NP_001274094.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple coding region differences compared to variant 1 and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' UTR, compared to variant 1. It encodes isoform 3 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC118592, BC050911, BC099600
      Consensus CDS
      CCDS85360.1
      UniProtKB/Swiss-Prot
      Q6PFD9
      UniProtKB/TrEMBL
      B2RQL0, Q4FZE7
      Related
      ENSMUSP00000147486.2, ENSMUST00000211235.2
      Conserved Domains (2) summary
      pfam04096
      Location:723863
      Nucleoporin2; Nucleoporin autopeptidase
      pfam13634
      Location:69161
      Nucleoporin_FG; Nucleoporin FG repeat region
    3. NM_001287166.1NP_001274095.1  nuclear pore complex protein Nup98-Nup96 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has multiple coding region differences compared to variant 1 and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' UTR, compared to variant 1. It encodes isoform 4 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC118592, AK164402
      Consensus CDS
      CCDS85359.1
      UniProtKB/TrEMBL
      A0A1B0GRB5, Q3TPG3
      Related
      ENSMUSP00000147454.2, ENSMUST00000211022.2
      Conserved Domains (2) summary
      pfam04096
      Location:723863
      Nucleoporin2; Nucleoporin autopeptidase
      pfam13634
      Location:69161
      Nucleoporin_FG; Nucleoporin FG repeat region
    4. NM_001287167.1NP_001274096.1  nuclear pore complex protein Nup98-Nup96 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks several exons, and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' UTR, compared to variant 1. It encodes isoform 5 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC118592, AK146491
      Consensus CDS
      CCDS85357.1
      UniProtKB/TrEMBL
      A0A1B0GRA7, Q3UJE5
      Related
      ENSMUSP00000147445.2, ENSMUST00000211005.2
      Conserved Domains (2) summary
      pfam04096
      Location:740880
      Nucleoporin2; Nucleoporin autopeptidase
      pfam13634
      Location:69161
      Nucleoporin_FG; Nucleoporin FG repeat region
    5. NM_022979.2NP_075355.1  nuclear pore complex protein Nup98-Nup96 isoform 2

      See identical proteins and their annotated locations for NP_075355.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several exons and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' UTR, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC118592, BC050911, BC099600
      Consensus CDS
      CCDS21528.1
      UniProtKB/Swiss-Prot
      Q6PFD9
      UniProtKB/TrEMBL
      A0A140T8J8, Q4FZE7
      Related
      ENSMUSP00000068530.6, ENSMUST00000070165.7
      Conserved Domains (2) summary
      pfam04096
      Location:740880
      Nucleoporin2; Nucleoporin autopeptidase
      pfam13634
      Location:69161
      Nucleoporin_FG; Nucleoporin FG repeat region

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      101768607..101859375 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507896.4XP_006507959.1  nuclear pore complex protein Nup98-Nup96 isoform X2

      Conserved Domains (3) summary
      pfam04096
      Location:723863
      Nucleoporin2; Nucleoporin autopeptidase
      pfam12110
      Location:13161605
      Nup96; Nuclear protein 96
      pfam13634
      Location:40149
      Nucleoporin_FG; Nucleoporin FG repeat region
    2. XM_030242624.1XP_030098484.1  nuclear pore complex protein Nup98-Nup96 isoform X4

      Conserved Domains (3) summary
      pfam04096
      Location:676816
      Nucleoporin2; Nucleoporin autopeptidase
      pfam12110
      Location:12691558
      Nup96; Nuclear protein 96
      pfam13634
      Location:40149
      Nucleoporin_FG; Nucleoporin FG repeat region
    3. XM_006507897.3XP_006507960.1  nuclear pore complex protein Nup98-Nup96 isoform X3

      Conserved Domains (3) summary
      pfam04096
      Location:693833
      Nucleoporin2; Nucleoporin autopeptidase
      pfam12110
      Location:12861575
      Nup96; Nuclear protein 96
      pfam13634
      Location:40149
      Nucleoporin_FG; Nucleoporin FG repeat region
    4. XM_030242623.1XP_030098483.1  nuclear pore complex protein Nup98-Nup96 isoform X2

      Conserved Domains (3) summary
      pfam04096
      Location:723863
      Nucleoporin2; Nucleoporin autopeptidase
      pfam12110
      Location:13161605
      Nup96; Nuclear protein 96
      pfam13634
      Location:40149
      Nucleoporin_FG; Nucleoporin FG repeat region
    5. XM_006507895.3XP_006507958.1  nuclear pore complex protein Nup98-Nup96 isoform X1

      See identical proteins and their annotated locations for XP_006507958.1

      UniProtKB/TrEMBL
      A0A1B0GSX7
      Conserved Domains (3) summary
      pfam04096
      Location:740880
      Nucleoporin2; Nucleoporin autopeptidase
      pfam12110
      Location:13331622
      Nup96; Nuclear protein 96
      pfam13634
      Location:40149
      Nucleoporin_FG; Nucleoporin FG repeat region
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