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    Chsy1 chondroitin sulfate synthase 1 [ Mus musculus (house mouse) ]

    Gene ID: 269941, updated on 31-Jan-2019

    Summary

    Official Symbol
    Chsy1provided by MGI
    Official Full Name
    chondroitin sulfate synthase 1provided by MGI
    Primary source
    MGI:MGI:2681120
    See related
    Ensembl:ENSMUSG00000032640
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Expression
    Ubiquitous expression in ovary adult (RPKM 11.7), limb E14.5 (RPKM 11.5) and 25 other tissues See more
    Orthologs

    Genomic context

    See Chsy1 in Genome Data Viewer
    Location:
    7; 7 C
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (66109515..66173798)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (73254401..73318684)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene small nuclear ribonucleoprotein polypeptide A' Neighboring gene selenoprotein S Neighboring gene NSA2 ribosome biogenesis homolog pseudogene Neighboring gene predicted gene, 33442 Neighboring gene leucine-rich repeat kinase 1 Neighboring gene predicted gene, 45989

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0990

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    acetylgalactosaminyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity, transferring glycosyl groups IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    bone morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cartilage development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chondrocyte development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chondroitin sulfate biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    chondroitin sulfate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of ossification ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    proximal/distal pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sulfation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    chondroitin sulfate synthase 1
    Names
    N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 1
    N-acetylgalactosaminyltransferase 1
    carbohydrate (chondroitin) synthase 1
    chondroitin glucuronyltransferase 1
    glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase 1
    NP_001074632.1
    XP_006540973.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081163.2NP_001074632.1  chondroitin sulfate synthase 1 precursor

      See identical proteins and their annotated locations for NP_001074632.1

      Status: VALIDATED

      Source sequence(s)
      AC124695, AC127595
      Consensus CDS
      CCDS39978.1
      UniProtKB/Swiss-Prot
      Q6ZQ11
      Related
      ENSMUSP00000047487.6, ENSMUST00000036372.7
      Conserved Domains (2) summary
      pfam05679
      Location:237776
      CHGN; Chondroitin N-acetylgalactosaminyltransferase
      cl21608
      Location:86307
      Galactosyl_T; Galactosyltransferase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      66109515..66173798
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540910.3XP_006540973.1  chondroitin sulfate synthase 1 isoform X1

      Conserved Domains (2) summary
      pfam05679
      Location:88627
      CHGN; Chondroitin N-acetylgalactosaminyltransferase
      cl21608
      Location:8158
      Galactosyl_T; Galactosyltransferase
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