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    Brd7 bromodomain containing 7 [ Mus musculus (house mouse) ]

    Gene ID: 26992, updated on 31-Jan-2019

    Summary

    Official Symbol
    Brd7provided by MGI
    Official Full Name
    bromodomain containing 7provided by MGI
    Primary source
    MGI:MGI:1349766
    See related
    Ensembl:ENSMUSG00000031660
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BP75; CELTIX1; Ptpn13ip
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 13.7), CNS E14 (RPKM 11.2) and 28 other tissues See more
    Orthologs

    Genomic context

    See Brd7 in Genome Data Viewer
    Location:
    8; 8 C3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (88330598..88362251, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (90856210..90886090, complement)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene terminal nucleotidyltransferase 4B Neighboring gene adenylate cyclase 7 Neighboring gene predicted gene, 34751 Neighboring gene predicted gene, 39218

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    lysine-acetylated histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    p53 binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    transcription regulatory region DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of histone acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    bromodomain-containing protein 7
    Names
    75 kDa bromodomain protein
    bromodomain protein 75 kDa
    protein tyrosine phosphatase, non-receptor type 13 interacting protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012047.2NP_036177.1  bromodomain-containing protein 7

      See identical proteins and their annotated locations for NP_036177.1

      Status: VALIDATED

      Source sequence(s)
      AC155170
      Consensus CDS
      CCDS22510.1
      UniProtKB/Swiss-Prot
      O88665
      Related
      ENSMUSP00000034085.7, ENSMUST00000034085.7
      Conserved Domains (2) summary
      cd05513
      Location:135232
      Bromo_brd7_like; Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene ...
      pfam12024
      Location:287532
      DUF3512; Domain of unknown function (DUF3512)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      88330598..88362251 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531049.3XP_006531112.1  bromodomain-containing protein 7 isoform X3

      See identical proteins and their annotated locations for XP_006531112.1

      Conserved Domains (2) summary
      cd05513
      Location:135232
      Bromo_brd7_like; Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene ...
      pfam12024
      Location:287533
      DUF3512; Domain of unknown function (DUF3512)
    2. XM_006531048.3XP_006531111.1  bromodomain-containing protein 7 isoform X3

      See identical proteins and their annotated locations for XP_006531111.1

      Conserved Domains (2) summary
      cd05513
      Location:135232
      Bromo_brd7_like; Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene ...
      pfam12024
      Location:287533
      DUF3512; Domain of unknown function (DUF3512)
    3. XM_017312840.1XP_017168329.1  bromodomain-containing protein 7 isoform X4

      UniProtKB/Swiss-Prot
      O88665
      Conserved Domains (2) summary
      cd05513
      Location:135232
      Bromo_brd7_like; Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene ...
      pfam12024
      Location:287532
      DUF3512; Domain of unknown function (DUF3512)
    4. XM_006531046.3XP_006531109.1  bromodomain-containing protein 7 isoform X1

      Conserved Domains (2) summary
      cd05513
      Location:135232
      Bromo_brd7_like; Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene ...
      pfam12024
      Location:287533
      DUF3512; Domain of unknown function (DUF3512)
    5. XM_006531047.3XP_006531110.1  bromodomain-containing protein 7 isoform X2

      Conserved Domains (2) summary
      cd05513
      Location:135232
      Bromo_brd7_like; Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene ...
      pfam12024
      Location:287532
      DUF3512; Domain of unknown function (DUF3512)

    RNA

    1. XR_387746.3 RNA Sequence

    2. XR_387745.3 RNA Sequence

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