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    Brd7 bromodomain containing 7 [ Mus musculus (house mouse) ]

    Gene ID: 26992, updated on 18-Sep-2024

    Summary

    Official Symbol
    Brd7provided by MGI
    Official Full Name
    bromodomain containing 7provided by MGI
    Primary source
    MGI:MGI:1349766
    See related
    Ensembl:ENSMUSG00000031660 AllianceGenome:MGI:1349766
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BP75; CELTIX1; Ptpn13ip
    Summary
    Enables transcription corepressor activity. Predicted to be involved in several processes, including negative regulation of G1/S transition of mitotic cell cycle; positive regulation of histone acetylation; and regulation of transcription, DNA-templated. Predicted to act upstream of or within Wnt signaling pathway. Located in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; lung; retina; and tooth. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human BRD7 (bromodomain containing 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 13.7), CNS E14 (RPKM 11.2) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Brd7 in Genome Data Viewer
    Location:
    8 C3; 8 43.07 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (89056522..89089249, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (88329894..88362252, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene microRNA 7071 Neighboring gene HEAT repeat containing 3 Neighboring gene terminal nucleotidyltransferase 4B Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:90808880-90809067 Neighboring gene adenylate cyclase 7 Neighboring gene STARR-positive B cell enhancer ABC_E6670 Neighboring gene predicted gene, 34751 Neighboring gene predicted gene, 39218

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (6)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lysine-acetylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables lysine-acetylated histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lysine-acetylated histone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables p53 binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables p53 binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin remodeling NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of G1/S transition of mitotic cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of T cell differentiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of cell differentiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of double-strand break repair NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of myoblast differentiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of G0 to G1 transition NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of G1/S transition of mitotic cell cycle NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mitotic metaphase/anaphase transition NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of nucleotide-excision repair NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in transcription initiation-coupled chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transcription initiation-coupled chromatin remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of RSC-type complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of SWI/SNF superfamily-type complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromatin NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in kinetochore NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in nuclear matrix NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    bromodomain-containing protein 7
    Names
    75 kDa bromodomain protein
    bromodomain protein 75 kDa
    protein tyrosine phosphatase, non-receptor type 13 interacting protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001377013.1NP_001363942.1  bromodomain-containing protein 7 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: Variants 2 and 6 encode the same isoform (2).
      Source sequence(s)
      AC155170
      UniProtKB/TrEMBL
      A0AA74KT86
      Conserved Domains (2) summary
      cd05513
      Location:135232
      Bromo_brd7_like; Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene ...
      pfam12024
      Location:287533
      DUF3512; Domain of unknown function (DUF3512)
    2. NM_001377014.1NP_001363943.1  bromodomain-containing protein 7 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC155170
      UniProtKB/TrEMBL
      A0AA74KT86
      Conserved Domains (2) summary
      cd05513
      Location:135232
      Bromo_brd7_like; Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene ...
      pfam12024
      Location:287532
      DUF3512; Domain of unknown function (DUF3512)
    3. NM_001377015.1NP_001363944.1  bromodomain-containing protein 7 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC155170
      UniProtKB/TrEMBL
      A0AA74KT86
      Conserved Domains (2) summary
      cd05513
      Location:135232
      Bromo_brd7_like; Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene ...
      pfam12024
      Location:287533
      DUF3512; Domain of unknown function (DUF3512)
    4. NM_001377016.1NP_001363945.1  bromodomain-containing protein 7 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: Variants 1 and 5 encode the same isoform (1).
      Source sequence(s)
      AC155170
      UniProtKB/Swiss-Prot
      O88665, Q3UQ56, Q3UU06, Q9CT78
      UniProtKB/TrEMBL
      A0AA74KT86
      Conserved Domains (2) summary
      cd05513
      Location:135232
      Bromo_brd7_like; Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene ...
      pfam12024
      Location:287532
      DUF3512; Domain of unknown function (DUF3512)
    5. NM_001377017.1NP_001363946.1  bromodomain-containing protein 7 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: Variants 2 and 6 encode the same isoform (2).
      Source sequence(s)
      AC155170
      UniProtKB/TrEMBL
      A0AA74KT86
      Conserved Domains (2) summary
      cd05513
      Location:135232
      Bromo_brd7_like; Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene ...
      pfam12024
      Location:287533
      DUF3512; Domain of unknown function (DUF3512)
    6. NM_012047.3NP_036177.1  bromodomain-containing protein 7 isoform 1

      See identical proteins and their annotated locations for NP_036177.1

      Status: VALIDATED

      Description
      Transcript Variant: Variants 1 and 5 encode the same isoform (1).
      Source sequence(s)
      AC155170
      Consensus CDS
      CCDS22510.1
      UniProtKB/Swiss-Prot
      O88665, Q3UQ56, Q3UU06, Q9CT78
      UniProtKB/TrEMBL
      A0AA74KT86
      Related
      ENSMUSP00000034085.8, ENSMUST00000034085.8
      Conserved Domains (2) summary
      cd05513
      Location:135232
      Bromo_brd7_like; Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene ...
      pfam12024
      Location:287532
      DUF3512; Domain of unknown function (DUF3512)

    RNA

    1. NR_165043.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC155170
    2. NR_165044.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC155170
    3. NR_165045.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC155170

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      89056522..89089249 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_003947288.2 RNA Sequence

    2. XR_387746.5 RNA Sequence