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    Eif4e2 eukaryotic translation initiation factor 4E member 2 [ Mus musculus (house mouse) ]

    Gene ID: 26987, updated on 6-Sep-2021

    Summary

    Official Symbol
    Eif4e2provided by MGI
    Official Full Name
    eukaryotic translation initiation factor 4E member 2provided by MGI
    Primary source
    MGI:MGI:1914440
    See related
    Ensembl:ENSMUSG00000026254
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Eif4e; Eif4el3; AI036339; AV129531; D0H0S6743; D0H0S6743E; 2700069E09Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 12.5), placenta adult (RPKM 6.8) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Eif4e2 in Genome Data Viewer
    Location:
    1; 1 C5
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (87141633..87168210)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (87213911..87240488)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (89110489..89137063)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene cholinergic receptor, nicotinic, delta polypeptide Neighboring gene cholinergic receptor, nicotinic, gamma polypeptide Neighboring gene predicted gene, 53571 Neighboring gene predicted gene, 26187 Neighboring gene EF hand domain containing 1 Neighboring gene predicted gene, 41911

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA 7-methylguanosine cap binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in P-body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of eukaryotic translation initiation factor 4F complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of mRNA cap binding complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    eukaryotic translation initiation factor 4E type 2
    Names
    eIF-4E type 2
    eIF4E type 2
    eIF4E-2
    eIF4E-like protein 4E-LP
    eukaryotic translation initiation factor 4E like 3
    mRNA cap-binding protein type 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039169.1NP_001034258.1  eukaryotic translation initiation factor 4E type 2 isoform 2

      See identical proteins and their annotated locations for NP_001034258.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice junction at the 3' end of the first exon compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC102611, AK017221
      Consensus CDS
      CCDS15131.1
      UniProtKB/TrEMBL
      Q0P688
      Related
      ENSMUSP00000108857.4, ENSMUST00000113231.4
      Conserved Domains (1) summary
      pfam01652
      Location:50208
      IF4E; Eukaryotic initiation factor 4E
    2. NM_001039170.1NP_001034259.1  eukaryotic translation initiation factor 4E type 2 isoform 1

      See identical proteins and their annotated locations for NP_001034259.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC102611, AK032965
      Consensus CDS
      CCDS35652.1
      UniProtKB/Swiss-Prot
      Q8BMB3
      Related
      ENSMUSP00000108859.2, ENSMUST00000113233.8
      Conserved Domains (1) summary
      pfam01652
      Location:55213
      IF4E; Eukaryotic initiation factor 4E
    3. NM_001347083.1NP_001334012.1  eukaryotic translation initiation factor 4E type 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC102611
      Consensus CDS
      CCDS83571.1
      UniProtKB/TrEMBL
      D3Z729
      Related
      ENSMUSP00000108861.2, ENSMUST00000113235.8
      Conserved Domains (1) summary
      pfam01652
      Location:55213
      IF4E; Eukaryotic initiation factor 4E
    4. NM_023314.3NP_075803.2  eukaryotic translation initiation factor 4E type 2 isoform 3

      See identical proteins and their annotated locations for NP_075803.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate 3'-most exon compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC102611, AK032965, AK076067
      Consensus CDS
      CCDS15130.1
      UniProtKB/Swiss-Prot
      Q8BMB3
      UniProtKB/TrEMBL
      G3X9H1
      Related
      ENSMUSP00000075699.6, ENSMUST00000076362.12
      Conserved Domains (1) summary
      pfam01652
      Location:55213
      IF4E; Eukaryotic initiation factor 4E

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      87141633..87168210
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165581.1XP_036021474.1  eukaryotic translation initiation factor 4E type 2 isoform X1

      Conserved Domains (1) summary
      pfam01652
      Location:55214
      IF4E; Eukaryotic initiation factor 4E
    2. XM_036165586.1XP_036021479.1  eukaryotic translation initiation factor 4E type 2 isoform X3

      Conserved Domains (1) summary
      pfam01652
      Location:55214
      IF4E; Eukaryotic initiation factor 4E
    3. XM_006529674.4XP_006529737.1  eukaryotic translation initiation factor 4E type 2 isoform X7

      UniProtKB/TrEMBL
      D3YUV9
      Related
      ENSMUSP00000053403.8, ENSMUST00000050876.14
      Conserved Domains (1) summary
      pfam01652
      Location:55214
      IF4E; Eukaryotic initiation factor 4E
    4. XM_030254746.1XP_030110606.1  eukaryotic translation initiation factor 4E type 2 isoform X5

      Conserved Domains (1) summary
      pfam01652
      Location:50209
      IF4E; Eukaryotic initiation factor 4E
    5. XM_030254745.1XP_030110605.1  eukaryotic translation initiation factor 4E type 2 isoform X4

      Conserved Domains (1) summary
      pfam01652
      Location:50209
      IF4E; Eukaryotic initiation factor 4E
    6. XM_036165583.1XP_036021476.1  eukaryotic translation initiation factor 4E type 2 isoform X2

      Conserved Domains (1) summary
      pfam01652
      Location:50209
      IF4E; Eukaryotic initiation factor 4E
    7. XM_036165589.1XP_036021482.1  eukaryotic translation initiation factor 4E type 2 isoform X6

      Conserved Domains (1) summary
      pfam01652
      Location:50209
      IF4E; Eukaryotic initiation factor 4E

    RNA

    1. XR_004942584.1 RNA Sequence

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