Format

Send to:

Choose Destination
    • Showing Current items.

    CHORDC1 cysteine and histidine rich domain containing 1 [ Homo sapiens (human) ]

    Gene ID: 26973, updated on 25-Jan-2022

    Summary

    Official Symbol
    CHORDC1provided by HGNC
    Official Full Name
    cysteine and histidine rich domain containing 1provided by HGNC
    Primary source
    HGNC:HGNC:14525
    See related
    Ensembl:ENSG00000110172 MIM:604353; AllianceGenome:HGNC:14525
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CHP1
    Summary
    Enables Hsp90 protein binding activity. Predicted to be involved in centrosome duplication; chaperone-mediated protein folding; and regulation of cellular response to heat. [provided by Alliance of Genome Resources, Nov 2021]
    Expression
    Ubiquitous expression in lymph node (RPKM 9.0), appendix (RPKM 8.2) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CHORDC1 in Genome Data Viewer
    Location:
    11q14.3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (90200429..90223082, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (89933597..89956217, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene upstream binding transcription factor like 1 Neighboring gene N-acetylated alpha-linked acidic dipeptidase 2 Neighboring gene DISC1 fusion partner 1 Neighboring gene tubulin alpha pseudogene 2 Neighboring gene microRNA 4490

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of cysteine and histidine-rich domain (CHORD) containing 1 (CHORDC1) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Vpu vpu HIV-1 Vpu is identified to have a physical interaction with cysteine and histidine-rich domain containing 1 (CHORDC1; CHP1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ37289

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ADP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables Hsp90 protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in centrosome duplication IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in chaperone-mediated protein folding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cellular response to heat ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of centrosome duplication IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     

    General protein information

    Preferred Names
    cysteine and histidine-rich domain-containing protein 1
    Names
    CHORD-containing protein 1
    CHP-1
    chord domain-containing protein 1
    cysteine and histidine-rich domain (CHORD) containing 1
    cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1
    morgana
    protein morgana

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001144073.2NP_001137545.1  cysteine and histidine-rich domain-containing protein 1 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) is shorter compared to isoform a.
      Source sequence(s)
      AF123249, BC072461, CB852298, CF146721, CK300454
      Consensus CDS
      CCDS44705.1
      UniProtKB/Swiss-Prot
      Q9UHD1
      Related
      ENSP00000401080.2, ENST00000457199.6
      Conserved Domains (2) summary
      cd06488
      Location:211297
      p23_melusin_like; p23_like domain similar to the C-terminal (tail) domain of vertebrate Melusin and related proteins. Melusin's tail domain interacts with the cytoplasmic domain of beta1-A and beta1-D isoforms of beta1 integrin, it does not bind other integrin beta ...
      pfam04968
      Location:136197
      CHORD; CHORD
    2. NM_012124.3NP_036256.2  cysteine and histidine-rich domain-containing protein 1 isoform a

      See identical proteins and their annotated locations for NP_036256.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK290231, BC002339, BC072461, CB852298, CK300454
      Consensus CDS
      CCDS8289.1
      UniProtKB/Swiss-Prot
      Q9UHD1
      Related
      ENSP00000319255.6, ENST00000320585.11
      Conserved Domains (2) summary
      cd06488
      Location:230316
      p23_melusin_like; p23_like domain similar to the C-terminal (tail) domain of vertebrate Melusin and related proteins. Melusin's tail domain interacts with the cytoplasmic domain of beta1-A and beta1-D isoforms of beta1 integrin, it does not bind other integrin beta ...
      pfam04968
      Location:364
      CHORD; CHORD

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

      Range
      90200429..90223082 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017017540.2XP_016873029.1  cysteine and histidine-rich domain-containing protein 1 isoform X1

      Conserved Domains (2) summary
      cd06488
      Location:116202
      p23_melusin_like; p23_like domain similar to the C-terminal (tail) domain of vertebrate Melusin and related proteins. Melusin's tail domain interacts with the cytoplasmic domain of beta1-A and beta1-D isoforms of beta1 integrin, it does not bind other integrin beta ...
      pfam04968
      Location:41102
      CHORD; CHORD
    2. XM_017017541.2XP_016873030.1  cysteine and histidine-rich domain-containing protein 1 isoform X1

      Conserved Domains (2) summary
      cd06488
      Location:116202
      p23_melusin_like; p23_like domain similar to the C-terminal (tail) domain of vertebrate Melusin and related proteins. Melusin's tail domain interacts with the cytoplasmic domain of beta1-A and beta1-D isoforms of beta1 integrin, it does not bind other integrin beta ...
      pfam04968
      Location:41102
      CHORD; CHORD

    RNA

    1. XR_001747832.2 RNA Sequence

    Reference GRCh38.p13 PATCHES

    Genomic

    1. NW_019805497.1 Reference GRCh38.p13 PATCHES

      Range
      106552..129172 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center