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    Clip2 CAP-GLY domain containing linker protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 269713, updated on 16-Oct-2021

    Summary

    Official Symbol
    Clip2provided by MGI
    Official Full Name
    CAP-GLY domain containing linker protein 2provided by MGI
    Primary source
    MGI:MGI:1313136
    See related
    Ensembl:ENSMUSG00000063146
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Clip1; Cyln2; WSCR4; wbscr4; CLIP-115; mKIAA0291; B230327O20
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 28.5), CNS E18 (RPKM 28.0) and 24 other tissues See more
    Orthologs
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    Genomic context

    See Clip2 in Genome Data Viewer
    Location:
    5 G2; 5 74.63 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (134518237..134582922, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (134489383..134553767, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (134965256..135028304, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene general transcription factor II I repeat domain-containing 1 Neighboring gene ribosomal protein S28 pseudogene Neighboring gene syncytin a Neighboring gene microRNA 7228 Neighboring gene replication factor C (activator 1) 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables microtubule plus-end binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables microtubule plus-end binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables microtubule plus-end binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic microtubule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    colocalizes_with cytoplasmic microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendritic microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lamellar body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in microtubule plus-end IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in microtubule plus-end IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    CAP-Gly domain-containing linker protein 2
    Names
    cytoplasmic linker protein 1, 115 kDa
    cytoplasmic linker protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039162.2NP_001034251.1  CAP-Gly domain-containing linker protein 2 isoform b

      See identical proteins and their annotated locations for NP_001034251.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform b, which lacks an internal segment and is shorter, compared to isoform a.
      Source sequence(s)
      BC053048, BC121191
      Consensus CDS
      CCDS39309.1
      UniProtKB/Swiss-Prot
      Q9Z0H8
      Related
      ENSMUSP00000037431.7, ENSMUST00000036999.10
      Conserved Domains (4) summary
      TIGR04527
      Location:537623
      mycoplas_twoTM; two transmembrane protein
      pfam01302
      Location:223286
      CAP_GLY; CAP-Gly domain
      pfam10212
      Location:648836
      TTKRSYEDQ; Predicted coiled-coil domain-containing protein
      pfam13863
      Location:358452
      DUF4200; Domain of unknown function (DUF4200)
    2. NM_009990.3NP_034120.2  CAP-Gly domain-containing linker protein 2 isoform a

      See identical proteins and their annotated locations for NP_034120.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK045967, BC053048, BC121191
      Consensus CDS
      CCDS39310.1
      UniProtKB/Swiss-Prot
      Q9Z0H8
      Related
      ENSMUSP00000098212.3, ENSMUST00000100647.7
      Conserved Domains (2) summary
      COG1196
      Location:3571016
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam01302
      Location:222286
      CAP_GLY; CAP-Gly domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      134518237..134582922 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165158.1XP_036021051.1  CAP-Gly domain-containing linker protein 2 isoform X1

      Conserved Domains (2) summary
      COG5244
      Location:220853
      NIP100; Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]
      pfam01302
      Location:222286
      CAP_GLY; CAP-Gly domain

    RNA

    1. XR_004942523.1 RNA Sequence

    2. XR_003955655.2 RNA Sequence

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