Format

Send to:

Choose Destination
    • Showing Current items.

    Clip2 CAP-GLY domain containing linker protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 269713, updated on 31-Jan-2019

    Summary

    Official Symbol
    Clip2provided by MGI
    Official Full Name
    CAP-GLY domain containing linker protein 2provided by MGI
    Primary source
    MGI:MGI:1313136
    See related
    Ensembl:ENSMUSG00000063146
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Clip1; Cyln2; WSCR4; wbscr4; CLIP-115; mKIAA0291; B230327O20
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 28.5), CNS E18 (RPKM 28.0) and 24 other tissues See more
    Orthologs

    Genomic context

    See Clip2 in Genome Data Viewer
    Location:
    5 G2; 5 74.63 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (134489383..134552468, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (134965256..135028304, complement)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene general transcription factor II I repeat domain-containing 1 Neighboring gene ribosomal protein S28 pseudogene Neighboring gene syncytin a Neighboring gene microRNA 7228 Neighboring gene replication factor C (activator 1) 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule plus-end binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule plus-end binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with cytoplasmic microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasmic microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with cytoplasmic microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    dendritic microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    lamellar body ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule plus-end IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with microtubule plus-end IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    CAP-Gly domain-containing linker protein 2
    Names
    cytoplasmic linker protein 1, 115 kDa
    cytoplasmic linker protein 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039162.2NP_001034251.1  CAP-Gly domain-containing linker protein 2 isoform b

      See identical proteins and their annotated locations for NP_001034251.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform b, which lacks an internal segment and is shorter, compared to isoform a.
      Source sequence(s)
      BC053048, BC121191
      Consensus CDS
      CCDS39309.1
      UniProtKB/Swiss-Prot
      Q9Z0H8
      Related
      ENSMUSP00000037431.6, ENSMUST00000036999.9
      Conserved Domains (4) summary
      TIGR04527
      Location:537623
      mycoplas_twoTM; two transmembrane protein
      pfam01302
      Location:223286
      CAP_GLY; CAP-Gly domain
      pfam10212
      Location:648836
      TTKRSYEDQ; Predicted coiled-coil domain-containing protein
      pfam13863
      Location:358452
      DUF4200; Domain of unknown function (DUF4200)
    2. NM_009990.3NP_034120.2  CAP-Gly domain-containing linker protein 2 isoform a

      See identical proteins and their annotated locations for NP_034120.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK045967, BC053048, BC121191
      Consensus CDS
      CCDS39310.1
      UniProtKB/Swiss-Prot
      Q9Z0H8
      Related
      ENSMUSP00000098212.2, ENSMUST00000100647.6
      Conserved Domains (4) summary
      TIGR04527
      Location:572658
      mycoplas_twoTM; two transmembrane protein
      pfam01302
      Location:223286
      CAP_GLY; CAP-Gly domain
      pfam10212
      Location:683871
      TTKRSYEDQ; Predicted coiled-coil domain-containing protein
      cl23887
      Location:380485
      DUF4349; Domain of unknown function (DUF4349)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      134489383..134552468 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504427.3XP_006504490.1  CAP-Gly domain-containing linker protein 2 isoform X1

      Conserved Domains (5) summary
      pfam01302
      Location:223286
      CAP_GLY; CAP-Gly domain
      pfam13863
      Location:358452
      DUF4200; Domain of unknown function (DUF4200)
      pfam17078
      Location:441672
      SHE3; SWI5-dependent HO expression protein 3
      cl00223
      Location:700794
      NusB_Sun; RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the ...
      cl09111
      Location:597680
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
    Support Center