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    Cul1 cullin 1 [ Mus musculus (house mouse) ]

    Gene ID: 26965, updated on 28-Aug-2021

    Summary

    Official Symbol
    Cul1provided by MGI
    Official Full Name
    cullin 1provided by MGI
    Primary source
    MGI:MGI:1349658
    See related
    Ensembl:ENSMUSG00000029686
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cul-1
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 25.9), bladder adult (RPKM 24.8) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Cul1 in Genome Data Viewer
    Location:
    6; 6 B2.3
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (47430666..47503078)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (47453732..47526144)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (47404323..47476138)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene contactin associated protein-like 2 Neighboring gene predicted gene, 53327 Neighboring gene RIKEN cDNA F830010H11 gene Neighboring gene TAR (HIV) RNA binding protein 2 pseudogene Neighboring gene predicted gene, 40371 Neighboring gene enhancer of zeste 2 polycomb repressive complex 2 subunit

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    contributes_to ubiquitin protein ligase activity IC
    Inferred by Curator
    more info
    PubMed 
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of Parkin-FBXW7-Cul1 ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of SCF ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of SCF ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of cullin-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of cullin-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355550.1NP_001342479.1  cullin-1

      Status: VALIDATED

      Source sequence(s)
      AC154014, AC154015
      Consensus CDS
      CCDS20095.1
      Conserved Domains (2) summary
      pfam00888
      Location:21660
      Cullin; Cullin family
      pfam10557
      Location:706767
      Cullin_Nedd8; Cullin protein neddylation domain
    2. NM_001355551.1NP_001342480.1  cullin-1

      Status: VALIDATED

      Source sequence(s)
      AC154014, AC154015
      Consensus CDS
      CCDS20095.1
      Related
      ENSMUSP00000122702.2, ENSMUST00000146200.8
      Conserved Domains (2) summary
      pfam00888
      Location:21660
      Cullin; Cullin family
      pfam10557
      Location:706767
      Cullin_Nedd8; Cullin protein neddylation domain
    3. NM_012042.4NP_036172.1  cullin-1

      See identical proteins and their annotated locations for NP_036172.1

      Status: VALIDATED

      Source sequence(s)
      AC154014, AC154015
      Consensus CDS
      CCDS20095.1
      UniProtKB/Swiss-Prot
      Q9WTX6
      Related
      ENSMUSP00000031697.9, ENSMUST00000031697.9
      Conserved Domains (2) summary
      pfam00888
      Location:21660
      Cullin; Cullin family
      pfam10557
      Location:706767
      Cullin_Nedd8; Cullin protein neddylation domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      47430666..47503078
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506189.5XP_006506252.1  cullin-1 isoform X1

      See identical proteins and their annotated locations for XP_006506252.1

      UniProtKB/Swiss-Prot
      Q9WTX6
      Conserved Domains (2) summary
      pfam00888
      Location:21660
      Cullin; Cullin family
      pfam10557
      Location:706767
      Cullin_Nedd8; Cullin protein neddylation domain
    2. XM_030255411.2XP_030111271.1  cullin-1 isoform X1

      Conserved Domains (2) summary
      pfam00888
      Location:21660
      Cullin; Cullin family
      pfam10557
      Location:706767
      Cullin_Nedd8; Cullin protein neddylation domain
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