U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Luzp1 leucine zipper protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 269593, updated on 27-Nov-2024

    Summary

    Official Symbol
    Luzp1provided by MGI
    Official Full Name
    leucine zipper protein 1provided by MGI
    Primary source
    MGI:MGI:107629
    See related
    Ensembl:ENSMUSG00000001089 AllianceGenome:MGI:107629
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Luzp; mFLJ00226; 2700072H04Rik
    Summary
    Acts upstream of or within artery development; neural fold bending; and ventricular septum development. Located in nucleus. Is expressed in several structures, including alimentary system; brain; pharyngo-tympanic tube; skin; and submandibular gland primordium. Orthologous to human LUZP1 (leucine zipper protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 24.4), cerebellum adult (RPKM 11.9) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Luzp1 in Genome Data Viewer
    Location:
    4 D3; 4 68.8 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (136189892..136282036)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (136462609..136554725)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31295 Neighboring gene 5-hydroxytryptamine (serotonin) receptor 1D Neighboring gene lysine (K)-specific demethylase 1A Neighboring gene STARR-positive B cell enhancer ABC_E6238 Neighboring gene STARR-positive B cell enhancer mm9_chr4:136177240-136177540 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene testis expressed 46 Neighboring gene lactamase, beta-like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC169408, MGC169410

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin filament binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in apical constriction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within artery development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in contractile ring contraction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within neural fold bending IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein localization to actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of protein complex stability IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in stress fiber assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within ventricular septum development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of CERF complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in actin filament ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in chromosome, centromeric region ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in ciliary basal body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in midbody ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in spindle midzone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in stress fiber ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in tight junction IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    leucine zipper protein 1
    Names
    leucine zipper motif-containing protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024452.2NP_077772.2  leucine zipper protein 1

      See identical proteins and their annotated locations for NP_077772.2

      Status: VALIDATED

      Source sequence(s)
      AK139583, AL671173
      Consensus CDS
      CCDS38923.1
      UniProtKB/Swiss-Prot
      A3KG96, Q3UV18, Q7TS71, Q8BQW1, Q8R4U7, Q99NG3, Q9CSL6
      UniProtKB/TrEMBL
      B2RQ68
      Related
      ENSMUSP00000130758.2, ENSMUST00000170102.8
      Conserved Domains (1) summary
      COG1196
      Location:19354
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      136189892..136282036
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030253587.2XP_030109447.1  leucine zipper protein 1 isoform X1

      UniProtKB/Swiss-Prot
      A3KG96, Q3UV18, Q7TS71, Q8BQW1, Q8R4U7, Q99NG3, Q9CSL6
      UniProtKB/TrEMBL
      B2RQ68
      Conserved Domains (1) summary
      COG1196
      Location:19354
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    2. XM_006538921.3XP_006538984.1  leucine zipper protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006538984.1

      UniProtKB/Swiss-Prot
      A3KG96, Q3UV18, Q7TS71, Q8BQW1, Q8R4U7, Q99NG3, Q9CSL6
      UniProtKB/TrEMBL
      B2RQ68
      Related
      ENSMUSP00000101475.3, ENSMUST00000105849.9
      Conserved Domains (1) summary
      COG1196
      Location:19354
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    3. XM_030253588.1XP_030109448.1  leucine zipper protein 1 isoform X2

      UniProtKB/TrEMBL
      B2RQ68
      Conserved Domains (1) summary
      COG1196
      Location:19354
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RNA

    1. XR_390755.2 RNA Sequence

    2. XR_390753.2 RNA Sequence