Format

Send to:

Choose Destination
    • Showing Current items.

    Vcp valosin containing protein [ Mus musculus (house mouse) ]

    Gene ID: 269523, updated on 5-Sep-2021

    Summary

    Official Symbol
    Vcpprovided by MGI
    Official Full Name
    valosin containing proteinprovided by MGI
    Primary source
    MGI:MGI:99919
    See related
    Ensembl:ENSMUSG00000028452
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p9; p97; p97/; CDC48; p97/VCP; 3110001E05
    Expression
    Ubiquitous expression in placenta adult (RPKM 109.8), adrenal adult (RPKM 109.0) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Vcp in Genome Data Viewer
    Location:
    4 A5; 4 22.95 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (42979964..43000507, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (42979964..43000507, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (42992836..43013379, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member B5 Neighboring gene RIKEN cDNA 1700022I11 gene Neighboring gene Fanconi anemia, complementation group G Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class O

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ADP binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables ADP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ATP binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables BAT3 complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables K48-linked polyubiquitin modification-dependent protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables MHC class I protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables deubiquitinase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables polyubiquitin modification-dependent protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables polyubiquitin modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-like protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-specific protease binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin-specific protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in ATP metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ER-associated misfolded protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in ER-associated misfolded protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in NADH metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within aggresome assembly IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in autophagosome maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in autophagosome maturation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to arsenite ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to heat ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endoplasmic reticulum stress-induced pre-emptive quality control ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endosome to lysosome transport via multivesicular body sorting pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in flavin adenine dinucleotide catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in macroautophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic spindle disassembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ATP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of Lys63-specific deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitochondrial membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of mitochondrial membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of oxidative phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein K63-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteasomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein-DNA covalent cross-linking repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of aerobic respiration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein localization to chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of synapse organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in retrograde protein transport, ER to cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in retrograde protein transport, ER to cytosol IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in retrograde protein transport, ER to cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in stress granule disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in translesion synthesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ubiquitin-dependent ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in ubiquitin-dependent ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in viral genome replication ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of ATPase complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    part_of Derlin-1 retrotranslocation complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of Derlin-1 retrotranslocation complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of VCP-NPL4-UFD1 AAA ATPase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of VCP-NPL4-UFD1 AAA ATPase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of VCP-NPL4-UFD1 AAA ATPase complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of VCP-NPL4-UFD1 AAA ATPase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of VCP-NSFL1C complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of VCP-NSFL1C complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
     
    located_in myelin sheath HDA PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of proteasome complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    transitional endoplasmic reticulum ATPase
    Names
    15S Mg(2+)-ATPase p97 subunit
    AAA ATPase p97
    Inv protein
    TER ATPase
    homolog of yeast cdc48
    NP_033529.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009503.4NP_033529.3  transitional endoplasmic reticulum ATPase

      See identical proteins and their annotated locations for NP_033529.3

      Status: VALIDATED

      Source sequence(s)
      AK153249, BY732145
      Consensus CDS
      CCDS18086.1
      UniProtKB/Swiss-Prot
      Q01853
      Related
      ENSMUSP00000030164.8, ENSMUST00000030164.8
      Conserved Domains (1) summary
      TIGR01243
      Location:25764
      CDC48; AAA family ATPase, CDC48 subfamily

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      42979964..43000507 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center